Zobrazeno 1 - 10
of 108
pro vyhledávání: '"Florian Grebien"'
Autor:
Sophie Edtmayer, Agnieszka Witalisz-Siepracka, Bernhard Zdársky, Kerstin Heindl, Stefanie Weiss, Thomas Eder, Sayantanee Dutta, Uwe Graichen, Sascha Klee, Omar Sharif, Rotraud Wieser, Balázs Győrffy, Valeria Poli, Emilio Casanova, Heinz Sill, Florian Grebien, Dagmar Stoiber
Publikováno v:
Cell Death and Disease, Vol 15, Iss 5, Pp 1-12 (2024)
Abstract Signal transducer and activator of transcription 3 (STAT3) is frequently overexpressed in patients with acute myeloid leukemia (AML). STAT3 exists in two distinct alternatively spliced isoforms, the full-length isoform STAT3α and the C-term
Externí odkaz:
https://doaj.org/article/fa3588b01db84ae4a00ac9b61c021e7a
Autor:
Milad Rasouli, Selina Troester, Florian Grebien, Bianca F. Goemans, C. Michel Zwaan, Olaf Heidenreich
Publikováno v:
HemaSphere, Vol 8, Iss 9, Pp n/a-n/a (2024)
Abstract Acute myeloid leukemia (AML) is an aggressive hematological malignancy with a heterogeneous molecular landscape. In the pediatric context, the NUP98 gene is a frequent target of chromosomal rearrangements that are linked to poor prognosis an
Externí odkaz:
https://doaj.org/article/67cdf313c7f94694b4e56c30c64b1c07
Autor:
Elizabeth Heyes, Anna S. Wilhelmson, Anne Wenzel, Gabriele Manhart, Thomas Eder, Mikkel B. Schuster, Edwin Rzepa, Sachin Pundhir, Teresa D’Altri, Anne-Katrine Frank, Coline Gentil, Jakob Woessmann, Erwin M. Schoof, Manja Meggendorfer, Jürg Schwaller, Torsten Haferlach, Florian Grebien, Bo T. Porse
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-18 (2023)
Abstract The myeloid transcription factor CEBPA is recurrently biallelically mutated (i.e., double mutated; CEBPA DM) in acute myeloid leukemia (AML) with a combination of hypermorphic N-terminal mutations (CEBPA NT), promoting expression of the leuk
Externí odkaz:
https://doaj.org/article/015f842398434c8ab9d3b64437bd9772
Autor:
Jessica Ebner, Johannes Schmoellerl, Martin Piontek, Gabriele Manhart, Selina Troester, Bing Z. Carter, Heidi Neubauer, Richard Moriggl, Gergely Szakács, Johannes Zuber, Thomas Köcher, Michael Andreeff, Wolfgang R. Sperr, Peter Valent, Florian Grebien
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The BCL-2 inhibitor Venetoclax is a promising agent for the treatment of acute myeloid leukemia (AML). However, many patients are refractory to Venetoclax, and resistance develops quickly. ATP-binding cassette (ABC) transporters mediate chem
Externí odkaz:
https://doaj.org/article/c9c4a1f7bca449409f4ee0bf6e5c440b
Autor:
Ludovica Proietti, Srikanth Kodali, Gemma Valcarcel, Anna Vanessa Lopez-Rubio, Patrizia Pessina, Thomas Eder, Yingzhi Cui, Florencia Levin, Bernhard Alber, Gabriele Manhart, Alessandro Fatica, Jose Louis Sardina, Bruno DI Stefano, Florian Grebien
Publikováno v:
HemaSphere, Vol 7, p e8249393 (2023)
Externí odkaz:
https://doaj.org/article/9d84021610664209a77b5009bd067c54
Autor:
Sophie Edtmayer, Agnieszka Witalisz-Siepracka, Bernhard Zdársky, Stefanie Weiss, Kerstin Fiedler, Thomas Eder, Valeria Poli, Florian Grebien, Dagmar Stoiber
Publikováno v:
HemaSphere, Vol 7, p e88717d6 (2023)
Externí odkaz:
https://doaj.org/article/21c0479d6ad74b76b7aba476e0ff85c2
Publikováno v:
HemaSphere, Vol 7, Iss 8, p e927 (2023)
Epigenetic regulation occurs on the level of compacting DNA into chromatin. The functional unit of chromatin is the nucleosome, which consists of DNA wrapped around a core of histone proteins. While canonical histone proteins are incorporated into ch
Externí odkaz:
https://doaj.org/article/8649de83bb0147c9a868707b99e5b192
Autor:
Milad Rasouli, Helen Blair, Selina Troester, Katarzyna Szoltysek, Rachel Cameron, Minoo Ashtiani, Anja Krippner-Heidenreich, Florian Grebien, Gerard McGeehan, C. Michel Zwaan, Olaf Heidenreich
Publikováno v:
HemaSphere, Vol 7, Iss 8, p e935 (2023)
Chromosomal translocations involving the NUP98 locus are among the most prevalent rearrangements in pediatric acute myeloid leukemia (AML). AML with NUP98 fusions is characterized by high expression of HOXA and MEIS1 genes and is associated with poor
Externí odkaz:
https://doaj.org/article/b8adce46b561481aa1130bd4653fcaf1
Autor:
Josefine Radke, Elisa Schumann, Julia Onken, Randi Koll, Güliz Acker, Bohdan Bodnar, Carolin Senger, Sascha Tierling, Markus Möbs, Peter Vajkoczy, Anna Vidal, Sandra Högler, Petra Kodajova, Dana Westphal, Friedegund Meier, Frank Heppner, Susanne Kreuzer-Redmer, Florian Grebien, Karsten Jürchott, Torben Redmer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-24 (2022)
Melanoma brain metastases (MBM) show heterogeneous therapeutic response determined by incompletely understood mechanisms. Here, the authors use a multi-OMICS approach and targeted sequencing (TargetSeq) to decipher programs that may define molecular
Externí odkaz:
https://doaj.org/article/5f4425782714454798970d794d958825
Publikováno v:
HemaSphere, Vol 7, Iss 7, p e923 (2023)
Recent studies have suggested that several oncogenic and tumor-suppressive proteins carry out their functions in the context of specific membrane-less cellular compartments. As these compartments, generally referred to as onco-condensates, are specif
Externí odkaz:
https://doaj.org/article/1df9794faeb84b918a3509c525a11229