Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Florian Glaus"'
Autor:
Florian Glaus, Karl-Heinz Altmann
Publikováno v:
CHIMIA, Vol 67, Iss 4 (2013)
This article describes the total synthesis of ripostatin B, which is a 14-membered macrolide of myxobacterial origin that inhibits E. coli RNA polymerase by a different mechanism of action than the first-line anti-tuberculosis drug rifampicin. Struct
Externí odkaz:
https://doaj.org/article/7b21642a638f4ea09f709c8e2ff414a3
Autor:
Ruben C. Hartkoorn, Priyanka Tare, Florian Glaus, Gisbert Schneider, Valakunja Nagaraja, Darija Dedić, Jens Kunze, José A. Aínsa, Stewart T. Cole, Liliana Rodrigues, Karl-Heinz Altmann
Publikováno v:
The Journal of Organic Chemistry. 83:7150-7172
Described is the total synthesis of the myxobacterial natural product ripostatin B and of a small number of analogs. Ripostatin B is a polyketide-derived 14-membered macrolide that acts as an inhibitor of bacterial RNA-polymerase, but is mechanistica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37b951859cf75487c9cabc10776224b0
https://doi.org/10.1021/acs.joc.8b00193
https://doi.org/10.1021/acs.joc.8b00193
Autor:
Florian Glaus, Marta Meazza, Mathias Kirk Thøgersen, Lars A. Leth, Karl Anker Jørgensen, Emma A. Bitsch, Liang Fu
Publikováno v:
Leth, L, Glaus, F, Meazza, M, Fu, L, Thøgersen, M K, Bitsch, E A & Jørgensen, K A 2016, ' Decarboxylative [4+2] Cycloaddition by Synergistic Palladium and Organocatalysis ', Angewandte Chemie International Edition, vol. 55, no. 49, pp. 15272-15276 . https://doi.org/10.1002/anie.201607788
A novel reaction based on synergistic catalysis, combining palladium- and organocatalysis has been developed. The palladium catalyst activates vinyl benzoxazinanones via a decarboxylation to undergo a [4+2] cycloaddition with iminium-ion activated α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1a190089cf75a7f829e1ccc0566d50ac
https://doi.org/10.1002/ange.201607788
https://doi.org/10.1002/ange.201607788
Publikováno v:
Ventura, A M, Glaus, F, Vergura, S & Jørgensen, K A 2016, ' Organocatalytic Strategy for the Enantioselective Cycloaddition to Trisubstituted Nitroolefins to Create Spirocyclohexene-Oxetane Scaffolds ', Angewandte Chemie International Edition, vol. 55, no. 7, pp. 2478-2482 . https://doi.org/10.1002/anie.201510731
The first catalytic enantioselective cycloaddition reaction to α,β,β-trisubstituted nitroolefins is reported. For this purpose, nitroolefin oxetanes were employed in the reaction with 2,4-dienals promoted by trienamine catalysis. This methodology
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6b7a233a4f7297211e750eb9fa6c69
https://doi.org/10.1002/anie.201510731
https://doi.org/10.1002/anie.201510731
Autor:
Jesse Hauver, Robert Landick, Andrey Feklistov, Karl-Heinz Altmann, Brian Bae, Agnieszka Lass-Napiorkowska, Tomasz Heyduk, Markus Kalesse, Seth A. Darst, Florian Glaus
Trapping RNA polymerase in the act The enzyme RNA polymerase (RNAP) finds promoter elements in the genome, separates (or “melts”) the DNA strands, and transcribes the template DNA strand to give RNA. A mobile clamp in RNAP plays a key role in ini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3bfbf24a2beab4a068844a56151e3b3
https://europepmc.org/articles/PMC5696265/
https://europepmc.org/articles/PMC5696265/
Autor:
Karl-Heinz Altmann, Florian Glaus
Publikováno v:
Angewandte Chemie. 127:1957-1961
Tiacumicin B (Lipiarmycin A3, Fidaxomicin) ist ein atypisches Makrolidantibiotikum, das klinisch zur Behandlung von Infektionen mit Clostridium difficile eingesetzt wird. Tiacumicin B ist auch ein potenter Hemmer von Mycobacterium tuberculosis, kann
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::80bc7ee3aa584d64534bc00d008a1d3f
https://doi.org/10.1002/ange.201409510
https://doi.org/10.1002/ange.201409510
Autor:
Florian Glaus, Karl-Heinz Altmann
Publikováno v:
Angewandte Chemie International Edition. 54:1937-1940
Tiacumicin B (lipiarmycin A3, fidaxomicin) is an atypical macrolide antibiotic which is used for the treatment of Clostridium difficile infections. Tiacumicin B is also a potent inhibitor of Mycobacterium tuberculosis, but due to its limited oral bio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d0798b64b6f47ec95490a4ad472e5cc0
https://doi.org/10.1002/anie.201409510
https://doi.org/10.1002/anie.201409510
Publikováno v:
ChemInform. 47
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::051896405fe1267535d915a0941f00cb
https://doi.org/10.1002/chin.201624115
https://doi.org/10.1002/chin.201624115
Autor:
Didier Zurwerra, Leo Betschart, Florian Glaus, Jürg Gertsch, Walter Ganci, Julia K. Schuster, Karl-Heinz Altmann
Publikováno v:
Chemistry - A European Journal. 18:16868-16883
A new total synthesis of the marine macrolide (-)-zampanolide (1) and the structurally and stereochemically related non-natural levorotatory enantiomer of (+)-dactylolide (2), that is, ent-2, has been developed. The synthesis features a high-yielding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::411ec21deff71471aade324af2bd9028
https://doi.org/10.1002/chem.201202553
https://doi.org/10.1002/chem.201202553
Autor:
Florian Glaus, Karl-Heinz Altmann
Publikováno v:
Angewandte Chemie International Edition; Vol 51
A modular and highly stereoselective synthesis of the title compound was developed. Key steps in the assembly of the carbon framework of ripostatin B were a stereoselective Paterson aldol reaction and a high-yielding ring-closing metathesis mediated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80ecec29d0724aae04fe5ab0f913f293
https://doi.org/10.1002/ange.201200871
https://doi.org/10.1002/ange.201200871