Dopamine regulates decision thresholds in human reinforcement learning in males

Autor: Karima Chakroun, Antonius Wiehler, Ben Wagner, David Mathar, Florian Ganzer, Thilo van Eimeren, Tobias Sommer, Jan Peters

Publikováno v: Nature Communications, Vol 14, Iss 1, Pp 1-14 (2023)

Abstract Dopamine fundamentally contributes to reinforcement learning, but recent accounts also suggest a contribution to specific action selection mechanisms and the regulation of response vigour. Here, we examine dopaminergic mechanisms underlying

Externí odkaz: https://doaj.org/article/6fb6176da3044439b1fa6b57fcb8cae7

Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making

Autor: Karima Chakroun, David Mathar, Antonius Wiehler, Florian Ganzer, Jan Peters

Publikováno v: eLife, Vol 9 (2020)

Involvement of dopamine in regulating exploration during decision-making has long been hypothesized, but direct causal evidence in humans is still lacking. Here, we use a combination of computational modeling, pharmacological intervention and functio

Externí odkaz: https://doaj.org/article/11a498eee8dd4ea8a71160de62ab424e

Author response: L-DOPA modulates activity in the vmPFC, nucleus accumbens, and VTA during threat extinction learning in humans

Autor: Jan Haaker, Florian Ganzer, Christoph W. Korn, Roland W. Esser

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5a2832a9db205bd677d94f9980930bf7
https://doi.org/10.7554/elife.65280.sa2

Dopaminergic modulation of the exploration/exploitation trade-off in human decision-making

Autor: Florian Ganzer, Antonius Wiehler, David Mathar, Jan Peters, Karima Chakroun

Publikováno v: eLife
eLife, 2020, 9, pp.e51260. ⟨10.7554/eLife.51260⟩
eLife, eLife Sciences Publication, 2020, 9, pp.e51260. ⟨10.7554/eLife.51260⟩
eLife, Vol 9 (2020)

SummaryA central issue in reinforcement learning and decision-making is whether to exploit knowledge of reward values, or to explore novel options. Although it is widely hypothesized that dopamine neurotransmission plays a key role in regulating this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9964d07b3b4076cc306c9e65327c847f
https://hal.sorbonne-universite.fr/hal-02877277

Oxazepam versus Clomethiazol in Alcohol Withdrawal Treatment

Autor: Silke Kuhn, Florian Ganzer, Walter de Millas, Christian Haasen

Publikováno v: European Addiction Research. 16:179-184

The pharmacological management of the alcohol withdrawal syndrome associated with alcohol dependence is heterogeneous; however, according to the guidelines, clomethiazol is the standard medication in Germany. Benzodiazepines offer another safe possib

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::260d79b0338d9adb4296c1a3d78a8042
https://doi.org/10.1159/000317246