Zobrazeno 1 - 10
of 77
pro vyhledávání: '"Florian Fröhlich"'
Autor:
Dmitry Shvarev, Caroline König, Nicole Susan, Lars Langemeyer, Stefan Walter, Angela Perz, Florian Fröhlich, Christian Ungermann, Arne Moeller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-12 (2024)
Abstract Cells depend on their endolysosomal system for nutrient uptake and downregulation of plasma membrane proteins. These processes rely on endosomal maturation, which requires multiple membrane fusion steps. Early endosome fusion is promoted by
Externí odkaz:
https://doaj.org/article/18ffc3ab95944c89abfd2dfd1e010c93
Autor:
Stevanus A. Listian, Anna-Carina Mazur, Matthijs Kol, Edwin Ufelmann, Sebastian Eising, Florian Fröhlich, Stefan Walter, Joost C.M. Holthuis, Caroline Barisch
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110609- (2024)
Summary: Dictyostelium discoideum is a professional phagocyte frequently used to study cellular processes underlying the recognition, engulfment, and infection course of microbial pathogens. Sphingolipids are abundant components of the plasma membran
Externí odkaz:
https://doaj.org/article/742f69788af446059dfc6b9f6218521d
Autor:
Carolin Körner, Jan-Hannes Schäfer, Bianca M. Esch, Kristian Parey, Stefan Walter, David Teis, Dovile Januliene, Oliver Schmidt, Arne Moeller, Florian Fröhlich
Publikováno v:
Cell Reports, Vol 43, Iss 8, Pp 114627- (2024)
Summary: Sphingolipid levels are crucial determinants of neurodegenerative disorders and therefore require tight regulation. The Orm protein family and ceramides inhibit the rate-limiting step of sphingolipid biosynthesis—the condensation of L-seri
Externí odkaz:
https://doaj.org/article/c8f3eada1df24b39974b9b16396655a3
Autor:
Dmitry Shvarev, Caroline König, Nicole Susan, Lars Langemeyer, Stefan Walter, Angela Perz, Florian Fröhlich, Christian Ungermann, Arne Moeller
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-2 (2024)
Externí odkaz:
https://doaj.org/article/2e3ac21c7e864f14903697eb73abea2b
Autor:
Jan-Hannes Schäfer, Carolin Körner, Bianca M. Esch, Sergej Limar, Kristian Parey, Stefan Walter, Dovile Januliene, Arne Moeller, Florian Fröhlich
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Sphingolipids are structural membrane components that also function in cellular stress responses. The serine palmitoyltransferase (SPT) catalyzes the rate-limiting step in sphingolipid biogenesis. Its activity is tightly regulated through mu
Externí odkaz:
https://doaj.org/article/bd763b3a85de4ed7b0aeea6ec5c0d1d0
Autor:
Amalia H. Megarioti, Bianca M. Esch, Alexandros Athanasopoulos, Dimitrios Koulouris, Manousos Makridakis, Vasiliki Lygirou, Martina Samiotaki, Jerome Zoidakis, Vicky Sophianopoulou, Bruno André, Florian Fröhlich, Christos Gournas
Publikováno v:
Cell Reports, Vol 42, Iss 12, Pp 113561- (2023)
Summary: Quiescence is a common cellular state, required for stem cell maintenance and microorganismal survival under stress conditions or starvation. However, the mechanisms promoting quiescence maintenance remain poorly known. Plasma membrane compo
Externí odkaz:
https://doaj.org/article/c27731d6dfd14f67987fe4b07a4b64c7
Autor:
Lena Clausmeyer, Florian Fröhlich
Publikováno v:
Contact, Vol 6 (2023)
Ceramides, as key components of cellular membranes, play essential roles in various cellular processes, including apoptosis, cell proliferation, and cell signaling. Ceramides are the precursors of all complex sphingolipids in eukaryotic cells. They a
Externí odkaz:
https://doaj.org/article/e88840f757c44e489d4fdd8bce0642a1
Autor:
Dmitry Shvarev, Jannis Schoppe, Caroline König, Angela Perz, Nadia Füllbrunn, Stephan Kiontke, Lars Langemeyer, Dovile Januliene, Kilian Schnelle, Daniel Kümmel, Florian Fröhlich, Arne Moeller, Christian Ungermann
Publikováno v:
eLife, Vol 11 (2022)
Lysosomes are essential for cellular recycling, nutrient signaling, autophagy, and pathogenic bacteria and viruses invasion. Lysosomal fusion is fundamental to cell survival and requires HOPS, a conserved heterohexameric tethering complex. On the mem
Externí odkaz:
https://doaj.org/article/def295925ee6473dbd2d3883d11521f1
Autor:
Bianca M Esch, Sergej Limar, André Bogdanowski, Christos Gournas, Tushar More, Celine Sundag, Stefan Walter, Jürgen J Heinisch, Christer S Ejsing, Bruno André, Florian Fröhlich
Publikováno v:
PLoS Genetics, Vol 16, Iss 8, p e1008745 (2020)
Sphingolipids are abundant and essential molecules in eukaryotes that have crucial functions as signaling molecules and as membrane components. Sphingolipid biosynthesis starts in the endoplasmic reticulum with the condensation of serine and palmitoy
Externí odkaz:
https://doaj.org/article/f15f92c4af7244398daf7ac4bcf75b8e
Autor:
Nora Kory, Susanne Grond, Siddhesh S. Kamat, Zhihuan Li, Natalie Krahmer, Chandramohan Chitraju, Ping Zhou, Florian Fröhlich, Ivana Semova, Christer Ejsing, Rudolf Zechner, Benjamin F. Cravatt, Robert V. Farese, Jr., Tobias C. Walther
Publikováno v:
Journal of Lipid Research, Vol 58, Iss 1, Pp 226-235 (2017)
Variations in the gene LDAH (C2ORF43), which encodes lipid droplet-associated hydrolase (LDAH), are among few loci associated with human prostate cancer. Homologs of LDAH have been identified as proteins of lipid droplets (LDs). LDs are cellular orga
Externí odkaz:
https://doaj.org/article/3ec52a4ce7e4467191376e0d18ab2f9f