Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Florian Fleischhacker"'
Autor:
Kenan A. J. Bozhueyuek, Annabell Linck, Yan-Ni Shi, Peter Grün, Andreas Tietze, Janik Kranz, Florian Fleischhacker, Sarah Nowak, Frank Wesche, Helge B. Bode
Publikováno v:
Nature Chemistry. 11:653-661
Non-ribosomal peptide synthetases (NRPSs) are giant enzyme machines that activate amino acids in an assembly line fashion. As NRPSs are not restricted to the incorporation of the 20 proteinogenic amino acids, their efficient manipulation would enable
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::601d5636f427c15906a28cc3d21d1f1c
https://doi.org/10.1038/s41557-019-0276-z
https://doi.org/10.1038/s41557-019-0276-z
Autor:
Andreas Tietze, Kenan A. J. Bozhüyük, Claus-Peter Niesert, Florian Fleischhacker, Helge B. Bode, Annabell Linck, Frank Wesche
Publikováno v:
Nature Chemistry. 10:275-281
Peptides derived from non-ribosomal peptide synthetases (NRPSs) represent an important class of pharmaceutically relevant drugs. Methods to generate novel non-ribosomal peptides or to modify peptide natural products in an easy and predictable way are
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3624b9c76f9cb765868775d8580bf136
https://doi.org/10.1038/nchem.2890
https://doi.org/10.1038/nchem.2890
Autor:
Frank Wesche, Kenan A. J. Bozhueyuek, Florian Fleischhacker, Helge B. Bode, Andreas Tietze, Sarah Nowak, Annabell Linck
Many important natural products are produced by non-ribosomal peptide synthetases (NRPSs) 1.These giant enzyme machines activate amino acids in an assembly line fashion in which a set of catalytically active domains is responsible for the section, ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99c0d09bb7cc34580166c151ea4531f5
https://doi.org/10.1101/354670
https://doi.org/10.1101/354670
Autor:
Helge B. Bode, Florian Fleischhacker, Friederike I. Nollmann, Edna Bode, Carsten Kegler, Tilman Ahrendt
Publikováno v:
ChemBioChem
An E. coli strain with deletions in five transaminases (ΔaspC ΔilvE ΔtyrB ΔavtA ΔybfQ) was constructed to be unable to degrade several amino acids. This strain was used as an expression host for the analysis of the amino acid configuration of no
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dc041b262f7420a048a54fe4841c0d07
Publikováno v:
ChemBioChem
Heterologous production of GameXPeptide A (1), as well as of the novel peptide natural products ambactin (2) and xenolindicins A-C (3 a-c), was achieved by using the "overlap extension PCR-yeast homologous recombination" (ExRec) method. ExRec cloning
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2659a4fe09566c78bcb730a8c132cfeb
https://pubmed.ncbi.nlm.nih.gov/24816640
https://pubmed.ncbi.nlm.nih.gov/24816640