Zobrazeno 1 - 10 of 10 pro vyhledávání: '"Florian Enzler"'
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Akademický článek
Impact of protein and small molecule interactions on kinase conformations
Autor: Valentina Kugler, Selina Schwaighofer, Andreas Feichtner, Florian Enzler, Jakob Fleischmann, Sophie Strich, Sarah Schwarz, Rebecca Wilson, Philipp Tschaikner, Jakob Troppmair, Veronika Sexl, Pascal Meier, Teresa Kaserer, Eduard Stefan
Publikováno v: eLife, Vol 13 (2024)
Protein kinases act as central molecular switches in the control of cellular functions. Alterations in the regulation and function of protein kinases may provoke diseases including cancer. In this study we investigate the conformational states of suc
Externí odkaz: https://doaj.org/article/71c92e4b1a0b490fa5cb3387e2ae8a9c
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3
Akademický článek
Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system
Autor: Laura Rinaldi, Rossella Delle Donne, Bruno Catalanotti, Omar Torres-Quesada, Florian Enzler, Federica Moraca, Robert Nisticò, Francesco Chiuso, Sonia Piccinin, Verena Bachmann, Herbert H Lindner, Corrado Garbi, Antonella Scorziello, Nicola Antonino Russo, Matthis Synofzik, Ulrich Stelzl, Lucio Annunziato, Eduard Stefan, Antonio Feliciello
Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Abstract Activation of G-protein coupled receptors elevates cAMP levels promoting dissociation of protein kinase A (PKA) holoenzymes and release of catalytic subunits (PKAc). This results in PKAc-mediated phosphorylation of compartmentalized substrat
Externí odkaz: https://doaj.org/article/365bbfa6102046adbb84b30bd59fe56c
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4
Akademický článek
Hedgehog and Gpr161: Regulating cAMP Signaling in the Primary Cilium
Autor: Philipp Tschaikner, Florian Enzler, Omar Torres-Quesada, Pia Aanstad, Eduard Stefan
Publikováno v: Cells, Vol 9, Iss 1, p 118 (2020)
Compartmentalization of diverse types of signaling molecules contributes to the precise coordination of signal propagation. The primary cilium fulfills this function by acting as a spatiotemporally confined sensory signaling platform. For the integri
Externí odkaz: https://doaj.org/article/9c15f1effaa646cc93108a81e4edc383
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5
Mutation-oriented profiling of autoinhibitory kinase conformations predicts RAF inhibitor efficacies
Autor: Eduard Stefan, Omar Torres-Quesada, Egon Ogris, Johanna E. Mayrhofer, Philipp Tschaikner, Andreas Feichtner, Florian Enzler, Andrea Raffeiner, Jakob Troppmair, Markus Hartl, Rainer Schneider, Roland G. Huber, Ruth Röck, Jakob Fleischmann
Publikováno v: Proceedings of the National Academy of Sciences of the United States of America
Significance The pharmaceutical targeting of mutated BRAF has shown promising clinical outcomes in patients with melanoma. However, more than 300 reported BRAF patient mutations and the occurrence of a kinase-drug resistance mechanism hamper patient-
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffd40c2c1fcc0d48064d424aa4bada7f
https://doi.org/10.1073/pnas.2012150117
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6
KinCon: Cell‐based recording of full‐length kinase conformations
Autor: Eduard Stefan, Philipp Tschaikner, Florian Enzler, Rainer Schneider
Publikováno v: Iubmb Life
The spectrum of kinase alterations displays distinct functional characteristics and requires kinase mutation‐oriented strategies for therapeutic interference. Besides phosphotransferase activity, protein abundance, and intermolecular interactions,
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c992244067218b3860e88ebe592a908
https://doi.org/10.1002/iub.2241
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7
Feedback inhibition of cAMP effector signaling by a chaperone-assisted ubiquitin system
Autor: Nicola Antonino Russo, Matthis Synofzik, Omar Torres-Quesada, Sonia Piccinin, Federica Moraca, Herbert Lindner, Bruno Catalanotti, Antonio Feliciello, Ulrich Stelzl, Verena Bachmann, Rossella Delle Donne, Laura Rinaldi, Corrado Garbi, Robert Nisticò, Antonella Scorziello, Lucio Annunziato, Francesco Chiuso, Eduard Stefan, Florian Enzler
Publikováno v: Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications 10(1), 2572 (2019). doi:10.1038/s41467-019-10037-y
Activation of G-protein coupled receptors elevates cAMP levels promoting dissociation of protein kinase A (PKA) holoenzymes and release of catalytic subunits (PKAc). This results in PKAc-mediated phosphorylation of compartmentalized substrates that c
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec72f16970a20ebd84c46f8fee3a1473
http://europepmc.org/articles/PMC6561907
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8
Abstract B45: Surveillance of RAS-RAF dynamics in vivo: Tracking activity conformations and drug-induced interactions
Autor: Omar Torres-Quesada, Jakob Troppmair, Ruth Röck, Eduard Stefan, Johanna E. Mayrhofer, Florian Enzler
Publikováno v: Molecular Cancer Research. 18:B45-B45
Live-cell recordings of protein conformations and interactions yield novel mechanistic insights into physiologic and pathologic protein functions. We have developed an adaptable and genetically encoded bioluminescence-based biosensor platform to prec
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::70cb9c08bca0831fde7b3326e20a928a
https://doi.org/10.1158/1557-3125.ras18-b45
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9
BRAF inhibitors promote intermediate BRAF(V600E) conformations and binary interactions with activated RAS
Autor: Ruth, Röck, Johanna E, Mayrhofer, Omar, Torres-Quesada, Florian, Enzler, Andrea, Raffeiner, Philipp, Raffeiner, Andreas, Feichtner, Roland G, Huber, Shohei, Koide, Susan S, Taylor, Jakob, Troppmair, Eduard, Stefan
Publikováno v: Science Advances
Patient mutation–specific BRAF inhibitors alter full-length kinase conformations and promote interactions with GTP-loaded RAS.
Oncogenic BRAF mutations initiate tumor formation by unleashing the autoinhibited kinase conformation and promoting
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ca62fb6e6204b702f6df0896a96391ba
https://pubmed.ncbi.nlm.nih.gov/31453322
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10
Acute cocaine-related health problems in patients presenting to an urban emergency department in Switzerland: a case series
Autor: M. Bruggisser, Matthias E. Liechti, Evangelia Liakoni, Florian Enzler, Michael Bodmer
Publikováno v: BMC Research Notes
Bodmer, Michael; Enzler, Florian; Liakoni, Evangelia; Bruggisser, Marcel; Liechti, Matthias E (2014). Acute cocaine-related health problems in patients presenting to an urban emergency department in Switzerland: a case series. BMC research notes, 7, p. 173. Biomed Central 10.1186/1756-0500-7-173
BACKGROUND Emergency departments may be a useful information source to describe the demographics and clinical characteristics of patients with acute cocaine-related medical problems. We therefore conducted a retrospective analysis of 165 acute, labor
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f023af6391b7e7922a4dc73a39586023
http://europepmc.org/articles/PMC3987164
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