Zobrazeno 1 - 10
of 60
pro vyhledávání: '"Florian Douam"'
Autor:
Saravanan Subramaniam, Devin Kenney, Archana Jayaraman, Aoife Kateri O’Connell, Sarah Walachowski, Paige Montanaro, Christoph Reinhardt, Giuseppe Colucci, Nicholas A. Crossland, Florian Douam, Markus Bosmann
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
Advanced age is associated with an increased susceptibility to Coronavirus Disease (COVID)-19 and more severe outcomes, although the underlying mechanisms are understudied. The lung endothelium is located next to infected epithelial cells and bystand
Externí odkaz:
https://doaj.org/article/96d310ad2ca94a3d983c9a3685c19e7e
Autor:
Da-Yuan Chen, Jacquelyn Turcinovic, Shuchen Feng, Devin J. Kenney, Chue Vin Chin, Manish C. Choudhary, Hasahn L. Conway, Marc Semaan, Brianna J. Close, Alexander H. Tavares, Scott Seitz, Nazimuddin Khan, Sebastian Kapell, Nicholas A. Crossland, Jonathan Z. Li, Florian Douam, Susan C. Baker, John H. Connor, Mohsan Saeed
Publikováno v:
iScience, Vol 26, Iss 5, Pp 106634- (2023)
Summary: A simple and robust cell culture system is essential for generating authentic SARS-CoV-2 stocks for evaluation of viral pathogenicity, screening of antiviral compounds, and preparation of inactivated vaccines. Evidence suggests that Vero E6,
Externí odkaz:
https://doaj.org/article/4ef512ed285e4127ae84089843aedd7f
Autor:
Madeline Loffredo, Hector Lucero, Da-Yuan Chen, Aoife O’Connell, Simon Bergqvist, Ahmad Munawar, Asanga Bandara, Steff De Graef, Stephen D. Weeks, Florian Douam, Mohsan Saeed, Ali H. Munawar
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract The lack of coronavirus-specific antiviral drugs has instigated multiple drug repurposing studies to redirect previously approved medicines for the treatment of SARS-CoV-2, the coronavirus behind the ongoing COVID-19 pandemic. A recent, larg
Externí odkaz:
https://doaj.org/article/e07d8710ce004328ab2ec83a48a74f35
Autor:
Wenlin Ren, Xiaohui Ju, Mingli Gong, Jun Lan, Yanying Yu, Quanxin Long, Devin J. Kenney, Aoife K. O’Connell, Yu Zhang, Jin Zhong, Guocai Zhong, Florian Douam, Xinquan Wang, Ailong Huang, Rong Zhang, Qiang Ding
Publikováno v:
mBio, Vol 13, Iss 2 (2022)
ABSTRACT Recently, highly transmissible severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants B.1.617.1 (Kappa), B.1.617.2 (Delta), and B.1.618 with mutations within the spike proteins were identified in India. The spike protein of Ka
Externí odkaz:
https://doaj.org/article/938bbb2b9a754e049e0dce3905d0cf26
Autor:
David W Sanders, Chanelle C Jumper, Paul J Ackerman, Dan Bracha, Anita Donlic, Hahn Kim, Devin Kenney, Ivan Castello-Serrano, Saori Suzuki, Tomokazu Tamura, Alexander H Tavares, Mohsan Saeed, Alex S Holehouse, Alexander Ploss, Ilya Levental, Florian Douam, Robert F Padera, Bruce D Levy, Clifford P Brangwynne
Publikováno v:
eLife, Vol 10 (2021)
Many enveloped viruses induce multinucleated cells (syncytia), reflective of membrane fusion events caused by the same machinery that underlies viral entry. These syncytia are thought to facilitate replication and evasion of the host immune response.
Externí odkaz:
https://doaj.org/article/a25f5d2a1fee480aabdd9b8491fcd288
Autor:
Wenlin Ren, Yunkai Zhu, Yuyan Wang, Hongyang Shi, Yin Yu, Gaowei Hu, Fei Feng, Xiaomin Zhao, Jun Lan, Jianping Wu, Devin J Kenney, Florian Douam, Yimin Tong, Jin Zhong, Youhua Xie, Xinquan Wang, Zhenghong Yuan, Dongming Zhou, Rong Zhang, Qiang Ding
Publikováno v:
PLoS Pathogens, Vol 17, Iss 3, p e1009392 (2021)
Coronavirus interaction with its viral receptor is a primary genetic determinant of host range and tissue tropism. SARS-CoV-2 utilizes ACE2 as the receptor to enter host cell in a species-specific manner. We and others have previously shown that ACE2
Externí odkaz:
https://doaj.org/article/927b723ecf2d4d9bb7a0e45c96e492ab
Autor:
Mariano Carossino, Devin Kenney, Aoife K. O’Connell, Paige Montanaro, Anna E. Tseng, Hans P. Gertje, Kyle A. Grosz, Maria Ericsson, Bertrand R. Huber, Susanna A. Kurnick, Saravanan Subramaniam, Thomas A. Kirkland, Joel R. Walker, Kevin P. Francis, Alexander D. Klose, Neal Paragas, Markus Bosmann, Mohsan Saeed, Udeni B. R. Balasuriya, Florian Douam, Nicholas A. Crossland
Publikováno v:
Viruses, Vol 14, Iss 3, p 535 (2022)
Animal models recapitulating COVID-19 are critical to enhance our understanding of SARS-CoV-2 pathogenesis. Intranasally inoculated transgenic mice expressing human angiotensin-converting enzyme 2 under the cytokeratin 18 promoter (K18-hACE2) represe
Externí odkaz:
https://doaj.org/article/f6b43f0802ad4855911f2d783877a9ee
Autor:
Harish N. Ramanathan, Shuo Zhang, Florian Douam, Katrina B. Mar, Jinhong Chang, Priscilla L. Yang, John W. Schoggins, Alexander Ploss, Brett D. Lindenbach
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT While the basic mechanisms of flavivirus entry and fusion are understood, little is known about the postfusion events that precede RNA replication, such as nucleocapsid disassembly. We describe here a sensitive, conditionally replication-def
Externí odkaz:
https://doaj.org/article/aee8a1244e744296af80d6a1ac424a93
Autor:
Florian Douam, Carly G. K. Ziegler, Gabriela Hrebikova, Bruno Fant, Robert Leach, Lance Parsons, Wei Wang, Jenna M. Gaska, Benjamin Y. Winer, Brigitte Heller, Alex K. Shalek, Alexander Ploss
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-19 (2018)
Humanized mice are an enabling technology to explore human immunity and disease. Here, Douam et al. provide an in-depth comparison of immune responses to yellow fever vaccine in human vaccinees, conventional and second-generation humanized mice and d
Externí odkaz:
https://doaj.org/article/74919627ccd0481f9143428c27498c08
Autor:
Florian Douam, Gabriela Hrebikova, Yentli E. Soto Albrecht, Julie Sellau, Yael Sharon, Qiang Ding, Alexander Ploss
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-17 (2017)
Analysis of virus replication on a single-cell level is often hampered by a lack of specific or sensitive enough reagents. Here, Douamet al. use RNA-flow technique to track (+) and (−) strand RNA of yellow fever virus in hematopoietic cells in mous
Externí odkaz:
https://doaj.org/article/9e697919b38849b796bf1377f8eb6d31