Zobrazeno 1 - 5
of 5
pro vyhledávání: '"Florian Donneger"'
Autor:
Marie Goutierre, Sana Al Awabdh, Florian Donneger, Emeline François, Daniel Gomez-Dominguez, Theano Irinopoulou, Liset Menendez de la Prida, Jean Christophe Poncer
Publikováno v:
Cell Reports, Vol 28, Iss 1, Pp 91-103.e7 (2019)
Summary: KCC2 regulates neuronal transmembrane chloride gradients and thereby controls GABA signaling in the brain. KCC2 downregulation is observed in numerous neurological and psychiatric disorders. Paradoxical, excitatory GABA signaling is usually
Externí odkaz:
https://doaj.org/article/e639bdd041d9453db79f8a9062f7a422
Autor:
Sabine Lévi, Marion Russeau, Oana Vigy, Martial Séveno, Philippe Marin, Florian Donneger, Pauline Weinzettl, Sana Al Awabdh, Marie Goutierre, Imane Moutkine, Jean Christophe Poncer
Publikováno v:
J Neurosci
The K+-Cl–cotransporter KCC2, encoded by theSlc12a5gene, is a neuron-specific chloride extruder that tunes the strength and polarity of GABAAreceptor-mediated transmission. In addition to its canonical ion transport function, KCC2 also regulates sp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::183186931c5b509484e6a5d96f8e5ac7
https://doi.org/10.1523/jneurosci.2926-20.2021
https://doi.org/10.1523/jneurosci.2926-20.2021
Publikováno v:
The Journal of Physiology
The Journal of Physiology, 2020, Epub ahead of print. ⟨10.1113/JP279221⟩
The Journal of Physiology, 2020, Epub ahead of print. ⟨10.1113/JP279221⟩
Key points Cation-chloride cotransporters (CCCs) play a critical role in controlling the efficacy and polarity of GABAA receptor (GABAA R)-mediated transmission in the brain, yet their expression and function in GABAergic interneurons has been overlo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::335f4191cdd5798c5f7305cf0f00f6b6
https://doi.org/10.1113/jp279221
https://doi.org/10.1113/jp279221
Autor:
Valerio Frazzini, Bertrand Mathon, Florian Donneger, Louis Cousyn, Aurélie Hanin, V.-H. Nguyen-Michel, Claude Adam, Virginie Lambrecq, Sophie Dupont, Jean Christophe Poncer, Franck Bielle, Vincent Navarro
Publikováno v:
Journal of neurology. 269(8)
Focal neuronal lipofuscinosis (FNL) is an uncommon epileptic disorder related to an excess of lipofuscin accumulation within dysmorphic-appearing neurons (DANs), whose epileptogenic mechanisms are still poorly understood. It shares some clinical and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::33f0072c5c4620eb5ba2e1d471598233
https://pubmed.ncbi.nlm.nih.gov/35254479
https://pubmed.ncbi.nlm.nih.gov/35254479
Transmembrane chloride gradients govern the efficacy and polarity of GABA signaling in neurons and are usually maintained by the activity of cation chloride cotransporters, such as KCC2 and NKCC1. Whereas their role is well established in cortical pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bc67478341b305283c80b2565d87710
