Výsledky vyhledávání - "Florian Descamps"

Akademický článek

A ß-Secretase Modulator Decreases Tau Pathology and Preserves Short-Term Memory in a Mouse Model of Neurofibrillary Degeneration

Autor: Marie Tautou, Sabiha Eddarkaoui, Florian Descamps, Paul-Emmanuel Larchanché, Jamal El Bakali, Liesel Mary Goveas, Mélanie Dumoulin, Chloé Lamarre, David Blum, Luc Buée, Patricia Melnyk, Nicolas Sergeant

Publikováno v: Frontiers in Pharmacology, Vol 12 (2021)

Identifying which among several in cellulo pharmacological activities is necessary for the proper in vivo activity is essential for further drug development against Alzheimer’s disease pathophysiological processes. An in-depth structure–activity

Externí odkaz: https://doaj.org/article/8935d38d81d34dc79eee67e56e27fe2a

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A Polyaminobiaryl-Based β-secretase Modulator Alleviates Cognitive Impairments, Amyloid Load, Astrogliosis, and Neuroinflammation in APPSwe/PSEN1ΔE9 Mice Model of Amyloid Pathology

Autor: Marie Tautou, Florian Descamps, Paul-Emmanuel Larchanché, Luc Buée, Jamal El Bakali, Patricia Melnyk, Nicolas Sergeant

Publikováno v: International Journal of Molecular Sciences; Volume 24; Issue 6; Pages: 5285

The progress in Alzheimer’s disease (AD) treatment suggests a combined therapeutic approach targeting the two lesional processes of AD, which include amyloid plaques made of toxic Aβ species and neurofibrillary tangles formed of aggregates of abno

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::760a5f1120af7c368d03c7cf81dedea3
https://doi.org/10.3390/ijms24065285

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A β-secretase modulator decreases Tau pathology and preserves short-term memory in a mouse model of neurofibrillary degeneration

Autor: Chloé Lamarre, Nicolas Sergeant, David Blum, Luc Buée, Florian Descamps, Mélanie Dumoulin, Paul-Emmanuel Larchanché, Sabiha Eddarkaoui, Marie Tautou, Patricia Melnyk

A structure-activity relationship has enabled us to identify two molecules, MAGS02-14 and PEL24-199, sharing a β-secretase modulatory effect but having or not a lysosomotropic activity, respectively. More importantly, MAGS02-14 and PEL24-199 only di

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fab4890e5dd6ed4d06d84f5fd52b09eb
https://hal.archives-ouvertes.fr/hal-03203349

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Quinazoline and phthalazine derivatives as novel melatonin receptor ligands analogues of agomelatine

Autor: Philippe Delagrange, Patricia Melnyk, Daniel Henri Caignard, Raphaël Bolteau, Florian Descamps, Mohamed Ettaoussi, Saïd Yous

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2020, 189, pp.112078-. ⟨10.1016/j.ejmech.2020.112078⟩
European Journal of Medicinal Chemistry, 2020, 189, pp.112078. ⟨10.1016/j.ejmech.2020.112078⟩

International audience; For further development of successors of Agomelatine through modulation of its pharmacokinetic properties, we report herein the design, synthesis and pharmacological results of a new family of melatonin receptor ligands. Issue

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a119ad2a16d626226293a69a1dfb0ef
https://hal.archives-ouvertes.fr/hal-03489716

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A phenotypic approach to the discovery of compounds that promote non-amyloidogenic processing of the amyloid precursor protein: Toward a new profile of indirect β-secretase inhibitors

Autor: Marion Gay, Caroline Evrard, Florian Descamps, Pascal Carato, Nicolas Renault, Mathilde Coevoet, Sabiha Eddarkaoui, Catherine Baud, Paul-Emmanuel Larchanché, Luc Buée, Jamal El Bakali, Valérie Vingtdeux, Nicolas Sergeant, Patricia Melnyk

Publikováno v: European Journal of Medicinal Chemistry
European Journal of Medicinal Chemistry, Elsevier, 2018, 159, pp.104-125. ⟨10.1016/j.ejmech.2018.08.092⟩
European Journal of Medicinal Chemistry, 2018, 159, pp.104-125. ⟨10.1016/j.ejmech.2018.08.092⟩

International audience; Dysregulation of the Amyloid Precursor Protein (APP) processing leading to toxic species of amyloid b peptides (Ab) is central to Alzheimer's disease (AD) etiology. Ab peptides are produced by sequential cleavage of APP by b-s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80839a0aaa7b9c15ee495150fae6e583
https://hal.archives-ouvertes.fr/hal-02060447/document

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