Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Florian Brockhaus"'
Autor:
Thomas Lehmann, Samopriyo Maitra, Hiromasa Inoue, Jorge Maspero, Florian Brockhaus, Mina Gaga, Sally E. Wenzel, Jing Li, Barbara Knorr, Eugene R. Bleecker, Caterina Brindicci, David Lawrence, Christopher E. Brightling
Publikováno v:
The Lancet Respiratory Medicine. 9:43-56
Fevipiprant, an oral antagonist of the prostaglandin DLUSTER-1 and LUSTER-2 were two phase 3 randomised, double-blind, placebo-controlled, parallel-group, replicate 52-week studies; LUSTER-1 took place at 174 clinical sites in 25 countries and LUSTER
Autor:
Karen Thomas, Ivanka Galeva, Gerhild Angyalosi, Mark Higgins, Michael W. Konstan, Alexander Chuchalin, Simon Piggott, Florian Brockhaus
Tobramycin inhalation powder (TIP) was reported to be effective in two Phase III studies in patients with cystic fibrosis (CF) chronically infected with Pseudomonas aeruginosa (Pa). The EDIT study evaluated the efficacy and safety of TIP manufactured
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14b5b7c87c4ed30dde67410df2069fa4
Autor:
Abhijit Pethe, Florian Brockhaus, Eric D. Bateman, Richard Kay, Robert G. Townley, Björn Holzhauer, Alfredo Guerreros
Publikováno v:
The European Respiratory Journal
Dose-related efficacy and safety of fevipiprant (QAW039), an oral DP2 (CRTh2) receptor antagonist, was assessed in patients with allergic asthma uncontrolled by low-dose inhaled corticosteroids (ICS). Adult patients were randomised to 12 weeks' treat
Autor:
Eric D. Bateman, Bjoern Holzhauer, Florian Brockhaus, Abhijit Pethe, Richard Kay, Robert G. Townley, Alfredo Guerreros
Publikováno v:
5.3 Allergy and Immunology.
Introduction We assessed the dose-related efficacy and safety of fevipiprant, an oral CRTh2 antagonist, in patients with atopic asthma uncontrolled on low-dose ICS therapy. Methods In this randomised, placebo-controlled, blinded, dose-finding study,
Autor:
David E. Geller, Michael W. Konstan, Florian Brockhaus, Jie Zhang, Gerhild Angyalosi, Predrag Minic
Publikováno v:
Pediatric Pulmonology. 46:230-238
Tobramycin inhalation solution is used to treat chronic Pseudomonas aeruginosa lung infection in cystic fibrosis patients. We evaluated the efficacy and safety of a novel, light-porous-particle, dry-powder formulation of tobramycin, which was develop
Publikováno v:
Molecular Medicine. 5:672-684
BACKGROUND: Previous work has suggested that an increase in expression of cyclooxygenase-2, concomitant formation of E-type prostanoids, and in turn intracellular cAMP conveys macrophage resistance against apoptosis. MATERIALS AND METHODS: We analyze
Autor:
Bernhard Brüne, Florian Brockhaus
Publikováno v:
Biochemical Journal. 338:295-303
Initiation of nitric oxide (NO•)-mediated apoptotic cell death in RAW 264.7 macrophages is associated with up-regulation of mitochondrial manganese superoxide dismutase (MnSOD; SOD2) and down-regulation of cytosolic copper zinc superoxide dismutase
Autor:
Florian Brockhaus, Bernhard Brüne
Publikováno v:
Experimental Cell Research. 238:33-41
Upon treatment with NO-releasing compounds such asS-nitrosoglutathione or spermine NO, human myeloid leukemia U937 cells undergo apoptosis. Early NO-mediated signals comprise activation of a Z-A-DCB (benzoyloxycarbonyl-Asp-CH2OC(O)-2,6-dichlorobenzen
Autor:
Ivanka Galeva, Mark Higgins, Florian Brockhaus, Gerhild Angyalosi, Michael W. Konstan, S. Piggott, K. Thomas, A.G. Chuchalin
Publikováno v:
Journal of Cystic Fibrosis. 11
WS5.5 A randomised, open label phase 3 study to evaluate the efficacy and safety of a dry powder formulation of inhaled colistimethate sodium (Colobreathe®) versus tobramycin nebuliser solution (TNS) in cystic fibrosis subjects with chronic Pseudomo
Publikováno v:
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society. 8(6)
In patients with cystic fibrosis (CF), respiratory infections with the opportunistic bacterial pathogen Pseudomonas aeruginosa have a major impact on morbidity and mortality. Aminoglycosides, especially tobramycin, have been used successfully to comb