Transcytosis maintains CFTR apical polarity in the face of constitutive and mutation-induced basolateral missorting

Autor: Ryosuke Fukuda, Gergely L. Lukacs, Florian Bossard, Andrea Schnúr, Haijin Xu, Guido Veit, Aurélien Bidaud-Meynard

Publikováno v: Journal of Cell Science
Journal of Cell Science, Company of Biologists, 2019, 132 (10), pp.jcs226886. ⟨10.1242/jcs.226886⟩
Journal of Cell Science, 2019, 132 (10), pp.jcs226886. ⟨10.1242/jcs.226886⟩
J Cell Sci

International audience; Apical polarity of cystic fibrosis transmembrane conductance regulator (CFTR) is essential for solute and water transport in secretory epithelia and can be impaired in human diseases. Maintenance of apical polarity in the face

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::209cb0348e44d4b7ff3850242f1449e7
https://doi.org/10.1101/411322

Fine Tuning of CFTR Traffic and Function by PDZ Scaffolding Proteins

Autor: C. Gauthier, Emilie Silantieff, Florian Bossard

Publikováno v: Cystic Fibrosis-Renewed Hopes Through Research

Cystic fibrosis (CF) is the most common lethal genetic disorder in Caucasian population (Welsh et al., 1995). This pathology is due to mutations in the CF transmembrane conductance regulator (CFTR) encoding gene leading to alterations or loss of func

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::94284c9f17696bd796404726f536f8c4
http://www.intechopen.com/articles/show/title/fine-tuning-of-cftr-traffic-and-function-by-pdz-scaffolding-proteins

β1, β2, and β3 adrenoceptors and Na+/H+ exchanger regulatory factor 1 expression in human bronchi and their modifications in cystic fibrosis

Autor: Florian Bossard, Bertrand Rozec, Emilie Silantieff, Chantal Gauthier, Christine Sagan, Emmanuelle Lavazais-Blancou, Amal Robay

Publikováno v: American journal of respiratory cell and molecular biology. 44(1)

To date, three β-adrenoceptor (β-AR) subtypes have been identified, but only β(1)-ARs and β(2)-ARs have been characterized in human lungs. Moreover, β(2)-ARs physically interact with the cystic fibrosis transmembrane conductance regulator (CFTR)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4eae2120991731f7205d2c843af28c4b
https://pubmed.ncbi.nlm.nih.gov/20203292

NHE-RF1 protein rescues DeltaF508-CFTR function

Autor: Shehrazade Dahimène, Gilles Toumaniantz, Florian Bossard, Amal Robay, Jean Mérot, C. Gauthier, Frédéric Becq

Publikováno v: American Journal of Physiology-Lung Cellular and Molecular Physiology
American Journal of Physiology-Lung Cellular and Molecular Physiology, American Physiological Society, 2007, 292 (5), pp.1085-1094. ⟨10.1152/ajplung.00445.2005⟩

(IF : 4,214); International audience; In cystic fibrosis (CF), the DeltaF508-CFTR anterograde trafficking from the endoplasmic reticulum to the plasma membrane is inefficient. New strategies for increasing the delivery of DeltaF508-CFTR to the apical

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b19502b2689689c0d931c9190770bd97
https://pubmed.ncbi.nlm.nih.gov/17237149

001 NHE-RF restaure une expression fonctionnelle et polarisée de CFTR- Δ F508

Autor: Florian Bossard, Gilles Toumaniantz, Jean Mérot, Frédéric Becq, A. Robayv, Chantal Gauthier

Publikováno v: Revue des Maladies Respiratoires. 22:843

Introduction La mucoviscidose est une maladie genetique autosomique recessive causee par des mutations du gene CFTR. Environ 70 % des patients possedent au moins un allele de la mutation la plus frequente, Δ F508. Dans les cellules, le trafic du mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5c43213c5754a0f88ea650217cf6bb30
https://doi.org/10.1016/s0761-8425(05)92413-3