Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Florian Bolze"'
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-11 (2017)
Abstract In rare cases, monogenetic obesity is caused by nonsense mutations in genes regulating energy balance. A key factor herein is the leptin receptor. Here, we focus on leptin receptor nonsense variants causing obesity, namely the human W31X, mu
Externí odkaz:
https://doaj.org/article/f0773e3ac67b4598903c56673d8c39ce
Autor:
Johannes Josef Fels, Henrik Søeborg, Inger Thorup, Mikala Skydsgaard, Lærke W. Andersen, Hanne Offenberg, Kevin A. Keane, Charlotte M. Dalsgaard, Ingrid Sjögren, Jennifer M. Rojas, Line Olrik Berthelsen, Jette Nowak, Florian Bolze, Jes Tovborg Jensen, Majken Dalgaard
Publikováno v:
Toxicologic Pathology. 46:777-798
The obese rodent serves as an indispensable tool for proof-of-concept efficacy and mode-of-action pharmacology studies. Yet the utility of this disease model as an adjunct to the conventional healthy animal in the nonclinical safety evaluation of ant
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::720b22f18b55257c12209b4651c6fd5d
https://doi.org/10.1177/0192623318803557
https://doi.org/10.1177/0192623318803557
Autor:
Emil Egecioglu, Majken Dalgaard, Marie Østergaard Pedersen, Birgitte Schjellerup Wulff, Mikala Skydsgaard, Alan Broadmeadow, Clare J. Chesher, Ridhirama Bhuwania, Esther Bloem, Emma Moore, Manuel Tena-Sempere, Hannah Williams, Lærke W. Andersen, Pia Søndergaard Galle, Florian Bolze, Johan F. Paulsson
Publikováno v:
Toxicology and Applied Pharmacology. 404:115152
Energy metabolism and reproduction are closely linked and reciprocally regulated. The detrimental effect of underweight on reproduction complicates the safety evaluation of anti-obesity drugs, making it challenging to distinguish pathological changes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::711c0139312e6bed6d38c6b05112dbcd
https://doi.org/10.1016/j.taap.2020.115152
https://doi.org/10.1016/j.taap.2020.115152
Autor:
Martin Klingenspor, Andrea Bast, Florian Bolze, Yongguo Li, Stefanie Maurer, Sabine Schweizer, Monja Willershäuser, Tobias Fromme
Publikováno v:
Adipose Tissue Biology ISBN: 9783319520292
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8f6c7525604452c3718e8231959d8e52
https://doi.org/10.1007/978-3-319-52031-5_4
https://doi.org/10.1007/978-3-319-52031-5_4
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1841:1345-1352
BRITE (brown-in-white) cells are brown adipocyte-like cells found in white adipose tissue (WAT) of rodents and/or humans. The recruitment of BRITE adipocytes, referred to as the browning of WAT, is hallmarked by the expression of UCP1 and exerts bene
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05e5122e84852f89a9e0d9b81554caf7
https://doi.org/10.1016/j.bbalip.2014.06.003
https://doi.org/10.1016/j.bbalip.2014.06.003
Autor:
Katja Steiger, James G. Fox, H. Carlo Maurer, Natasha Stephens Münch, Frederik Wein, Joanne Lysaght, Timothy C. Wang, Yoomi Lee, Maria E. Kavanagh, Andrew J. Dannenberg, Jonas Ingermann, Vincenz Sahm, Rachael Elliot, Henrik Einwächter, Florian Bolze, Dirk Haller, Peter R. Holt, Roland M. Schmid, Theresa Baumeister, Martin Klingenspor, Victoria Kellner, Michael Pollak, Michael Quante, Akanksha Anand, Maria Wiethaler, Hsin-Yu Fang, Tony Y. Ren, Rebecca C. Fitzgerald, Mark T. Whary, Richard A. Friedman, Sureshkumar Muthupalani
Publikováno v:
PMC
Gastroenterology
Gastroenterology
Background & Aims: Barrett's esophagus (BE) is a precursor to esophageal adenocarcinoma (EAC). Progression from BE to cancer is associated with obesity, possibly due to increased abdominal pressure and gastroesophageal reflux disease, although this p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0fa93905365caba57d3e7dcf73a8bc2f
https://doi.org/10.1053/j.gastro.2019.04.013
https://doi.org/10.1053/j.gastro.2019.04.013
Autor:
Nadine Rink, Volker Morath, Martin Klingenspor, Martin Schlapschy, Anika Zimmermann, Arne Skerra, Andrea Bast, Sabine Mocek, Detian Yuan, Mathias Heikenwalder, Florian Bolze
Publikováno v:
Diabetologia. 59(9)
Recombinant leptin offers a viable treatment for lipodystrophy (LD) syndromes. However, due to its short plasma half-life, leptin replacement therapy requires at least daily subcutaneous (s.c.) injections. Here, we optimised this treatment strategy i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f0d68475e83ee9fe9be2ffd9a109c51d
https://pubmed.ncbi.nlm.nih.gov/27272237
https://pubmed.ncbi.nlm.nih.gov/27272237
Autor:
Jessica Mühlhaus, Martin Klingenspor, Harald Brumm, S. Scherag, Johannes Hebebrand, Heike Biebermann, Anke Hinney, Susanna Wiegand, Florian Bolze, Heiko Krude, Annette Grüters
Publikováno v:
Obesity. 20:1074-1081
Aminoglycoside-mediated read-through of stop codons was recently demonstrated for a variety of diseases in vitro and in vivo. About 30 percent of human genetic diseases are the consequence of nonsense mutations. Nonsense mutations in obesity-associat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7816d403e052f25779dfc52229e0869
https://doi.org/10.1038/oby.2011.202
https://doi.org/10.1038/oby.2011.202
Autor:
Angelos Karlas, Monja Willershäuser, Tobias Fromme, Florian Bolze, Vasilis Ntziachristos, Martin Klingenspor, Sanna Laurila, Kirsi A. Virtanen, Jorge Alsina-Fernandez, Mueez U Din, Yongguo Li, Tamer Coskun, Andrea Bast-Habersbrunner, Minna Lahesmaa, Josefine Reber, Libbey S. O’Farrell, Pirjo Nuutila, Sarah-Madeleine Gabler, Katharina Schnabl
Publikováno v:
Cell. 175:1561-1574.e12
The molecular mediator and functional significance of meal-associated brown fat (BAT) thermogenesis remains elusive. Here, we identified the gut hormone secretin as a non-sympathetic BAT activator mediating prandial thermogenesis, which consequential
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15dc556cb8e26641603a14156ad1f27f
https://doi.org/10.1016/j.cell.2018.10.016
https://doi.org/10.1016/j.cell.2018.10.016
Autor:
Volker Morath, Katrin Seyfarth, Arne Skerra, Martin Klingenspor, Sarah Schneider, Martin Schlapschy, Ferdinand Sedlmayer, Florian Bolze
Publikováno v:
Molecular pharmaceutics. 12(5)
Leptin plays a central role in the control of energy homeostasis and appetite and, thus, has attracted attention for therapeutic approaches in spite of its limited pharmacological activity owing to the very short circulation in the body. To improve d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b84d864fbf30d6c1a6ca65c72c729de
https://pubmed.ncbi.nlm.nih.gov/25811325
https://pubmed.ncbi.nlm.nih.gov/25811325