Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Florian A. Horenkamp"'
Autor:
Santiago Manrique, Daniel Sauter, Florian A. Horenkamp, Sebastian Lülf, Hangxing Yu, Dominik Hotter, Kanchan Anand, Frank Kirchhoff, Matthias Geyer
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-14 (2017)
HIV and simian immunodeficiency virus (SIV) Nef proteins both stimulate the clathrin-mediated endocytosis of CD4 but differ in downmodulation of the immune receptor CD3. Here, the authors present the structure of SIV Nef bound to the ExxxLM motif of
Externí odkaz:
https://doaj.org/article/3181fb545a0a4070b555e5f08f37e628
Autor:
Thierry Doan, Erdem Karatekin, Christopher D. A. Rodrigues, Nathan D. Williams, Florian A. Horenkamp, Chenxiang Lin, Ned S. Wingreen, Anna Andronicos, Ane Landajuela, Martha Braun, A. Martínez-Calvo, David Z. Rudner, Vladimir Shteyn
Little is known about mechanisms of membrane fission in bacteria despite their requirement for cytokinesis. The only known dedicated membrane fission machinery in bacteria, FisB, is expressed during sporulation in Bacillus subtilis and is required to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3e448d49d6aaa972feedf3457a75b4ab
https://doi.org/10.1101/2020.09.25.313023
https://doi.org/10.1101/2020.09.25.313023
Autor:
Karin M. Reinisch, Marianna Leonzino, Joshua A. Lees, Florian A. Horenkamp, William Hancock-Cerutti, Heather E. Wheeler, Nikit Kumar, Pietro De Camilli, PeiQi Li
Publikováno v:
The Journal of Cell Biology
Structural and biochemical studies show that VPS13 family proteins are lipid transporters. VPS13A and VPS13C tether the ER to mitochondria and to endosomes/lysosomes, respectively, suggesting lipid dyshomeostasis as the cause of chorea acanthocytosis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dead21bd4cc819fa2cdecc7131905972
http://europepmc.org/articles/PMC6168267
http://europepmc.org/articles/PMC6168267
Autor:
Christopher D. A. Rodrigues, Vladimir Shteyn, Ane Landajuela, David Z. Rudner, Nathan D. Williams, Erdem Karatekin, Chenxiang Lin, Martha Braun, Anna Andronicos, Thierry Doan, Florian A. Horenkamp
Publikováno v:
Biophysical Journal. 120:322a
Little is known about mechanisms of membrane fission in bacteria despite their requirement for cytokinesis. The only known dedicated membrane fission machinery in bacteria, FisB, is expressed during sporulation in Bacillus subtilis and is required to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0ebc1de1e6b3baf8a26ee104be0c415e
https://doi.org/10.1016/j.bpj.2020.11.2033
https://doi.org/10.1016/j.bpj.2020.11.2033
Publikováno v:
The EMBO Journal. 37
Lipid transport proteins at membrane contact sites, where two organelles are closely apposed, play key roles in trafficking lipids between cellular compartments while distinct membrane compositions for each organelle are maintained. Understanding the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3481e1082c77b53bc7db304caf881e37
https://doi.org/10.15252/embj.201798002
https://doi.org/10.15252/embj.201798002
Autor:
Vladimir Shteyn, Craig R. Roy, Thomas J. Melia, Racquel Kim Sherwood, Karlina J. Kauffman, Karin M. Reinisch, Florian A. Horenkamp, Lara J. Kohler, Kathryn P. Krueger
Publikováno v:
Developmental Cell. 34:569-576
SummaryAutophagy is a conserved membrane transport pathway used to destroy pathogenic microbes that access the cytosol of cells. The intracellular pathogen Legionella pneumophila interferes with autophagy by delivering an effector protein, RavZ, into
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fc27b167222581af4b93baf05328b0a5
https://doi.org/10.1016/j.devcel.2015.08.010
https://doi.org/10.1016/j.devcel.2015.08.010
Publikováno v:
The Journal of Cell Biology
Characterization of the structure of the N-terminal portion of yeast Sac1 in complex with the phosphatidylinositol 4-kinase effector Vps74 identifies how Sac1 is directed to dephosphorylate PtdIns4P in the Golgi.
Sac1 is a phosphoinositide phosp
Sac1 is a phosphoinositide phosp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e36f7740a280a844b02edd145bc62be2
https://doi.org/10.1083/jcb.201404041
https://doi.org/10.1083/jcb.201404041
Autor:
Andree Hubber, Florian A. Horenkamp, Curtis M. Schauder, Shaeri Mukherjee, Karin M. Reinisch, Craig R. Roy, Eric Alix
Publikováno v:
Traffic. 15:488-499
Tethering proteins play a key role in vesicular transport, ensuring that cargo arrives at a specific destination. The bacterial effector protein SidC and its paralog SdcA have been described as tethering factors encoded by the intracellular pathogen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b2eb6e214aee434d32aa6deda670b121
https://doi.org/10.1111/tra.12158
https://doi.org/10.1111/tra.12158
Autor:
Florian A. Horenkamp, Sebastian Breuer, Matthias Geyer, Michael Weyand, Kalle Saksela, Sebastian Lülf, Antje Schulte
Publikováno v:
Traffic; Vol 12
The human immunodeficiency virus 1 (HIV-1) Nef protein is a pathogenicity factor required for effective progression to AIDS, which modulates host cell signaling pathways and T-cell receptor internalization. We have determined the crystal structure of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::069dab67524b3b8862846809683664ed
Autor:
Zulema A. Percario, Paola Borghi, Giorgio Mangino, Florian A. Horenkamp, Elisabetta Affabris, Matthias Geyer, Valeria Serra
Publikováno v:
Viral immunology. 25(2)
Despite the fact that murine cells are not permissive for human immunodeficiency virus type 1 (HIV-1) infection, several investigators have constructed transgenic (Tg) mice to model HIV-1-induced diseases to overcome this restriction. The generation
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7c166a06b8a5f6fb53b762e4fbfefe7
https://pubmed.ncbi.nlm.nih.gov/22413916
https://pubmed.ncbi.nlm.nih.gov/22413916