Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Florian A Schober"'
Autor:
David Alsina, Oleksandr Lytovchenko, Aleksandra Schab, Ilian Atanassov, Florian A Schober, Min Jiang, Camilla Koolmeister, Anna Wedell, Robert W Taylor, Anna Wredenberg, Nils‐Göran Larsson
Publikováno v:
EMBO Molecular Medicine, Vol 12, Iss 7, Pp 1-16 (2020)
Abstract Pathogenic variants in FBXL4 cause a severe encephalopathic syndrome associated with mtDNA depletion and deficient oxidative phosphorylation. To gain further insight into the enigmatic pathophysiology caused by FBXL4 deficiency, we generated
Externí odkaz:
https://doaj.org/article/a1607124f7c84b129339028002683006
Autor:
Aleksandra Pajak, Isabelle Laine, Paula Clemente, Najla El-Fissi, Florian A Schober, Camilla Maffezzini, Javier Calvo-Garrido, Rolf Wibom, Roberta Filograna, Ashish Dhir, Anna Wedell, Christoph Freyer, Anna Wredenberg
Publikováno v:
PLoS Genetics, Vol 15, Iss 7, p e1008240 (2019)
The RNA helicase SUV3 and the polynucleotide phosphorylase PNPase are involved in the degradation of mitochondrial mRNAs but their roles in vivo are not fully understood. Additionally, upstream processes, such as transcript maturation, have been link
Externí odkaz:
https://doaj.org/article/ea7ce131776e4971ad749d7f42cbb85b
Autor:
Paula Clemente, Javier Calvo-Garrido, Sarah F. Pearce, Florian A. Schober, Megumi Shigematsu, Stefan J. Siira, Isabelle Laine, Henrik Spåhr, Christian Steinmetzger, Katja Petzold, Yohei Kirino, Rolf Wibom, Oliver Rackham, Aleksandra Filipovska, Joanna Rorbach, Christoph Freyer, Anna Wredenberg
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
A subset of mitochondrial transcripts is not flanked by tRNAs and thus does not conform to the canonical mode of processing. Here, Clemente et al. demonstrate that phosphatase activity of ANGEL2 is required for correct processing of these transcripts
Externí odkaz:
https://doaj.org/article/72badb54eeff4560ac9bcd8f356122f9
Autor:
Javier Calvo-Garrido, Camilla Maffezzini, Florian A. Schober, Paula Clemente, Elias Uhlin, Malin Kele, Henrik Stranneheim, Nicole Lesko, Helene Bruhn, Per Svenningsson, Anna Falk, Anna Wedell, Christoph Freyer, Anna Wredenberg
Publikováno v:
Stem Cell Reports, Vol 12, Iss 4, Pp 696-711 (2019)
Summary: Neurodegenerative disorders are an increasingly common and irreversible burden on society, often affecting the aging population, but their etiology and disease mechanisms are poorly understood. Studying monogenic neurodegenerative diseases w
Externí odkaz:
https://doaj.org/article/325a48b5ac9c47b4bce704a2ebf2353e
Autor:
Marvin Thielert, Corazon Ericka Mae Itang, Constantin Ammar, Florian A Schober, Isabell Bludau, Patricia Skowronek, Maria Wahle, Wen-Feng Zeng, Xie-Xuan Zhou, Andreas-David Brunner, Sabrina Richter, Fabian J Theis, Martin Steger, Matthias Mann
Single-cell proteomics aims to characterize biological function and heterogeneity at the level of proteins in an unbiased manner. It is currently limited in proteomic depth, throughput and robustness, a challenge that we address here by a streamlined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a3fb68f6ef41609f753e695cd0ef7f6b
https://doi.org/10.1101/2022.12.02.518917
https://doi.org/10.1101/2022.12.02.518917
Autor:
Anna Wredenberg, Paula Clemente, Christoph Freyer, Anna Wedell, Elias Uhlin, Camilla Maffezzini, Henrik Stranneheim, Nicole Lesko, Florian A. Schober, Malin Kele, Per Svenningsson, Javier Calvo-Garrido, Anna Falk, Helene Bruhn
Publikováno v:
Stem Cell Reports
Stem Cell Reports, Vol 12, Iss 4, Pp 696-711 (2019)
Stem Cell Reports, Vol 12, Iss 4, Pp 696-711 (2019)
Summary Neurodegenerative disorders are an increasingly common and irreversible burden on society, often affecting the aging population, but their etiology and disease mechanisms are poorly understood. Studying monogenic neurodegenerative diseases wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df8bfc0974c1348ab309117e29877fe3
https://doi.org/10.1016/j.stemcr.2019.01.023
https://doi.org/10.1016/j.stemcr.2019.01.023
Autor:
Martin Engvall, Aki Kawasaki, Valerio Carelli, Rolf Wibom, Helene Bruhn, Nicole Lesko, Florian A. Schober, Anna Wredenberg, Anna Wedell, Frank Träisk
Publikováno v:
Frontiers in Neurology, Vol 12 (2021)
Leber hereditary optic neuropathy (LHON) is a mitochondrial disease causing severe bilateral visual loss, typically in young adults. The disorder is commonly caused by one of three primary point mutations in mitochondrial DNA, but a number of other r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doajarticles::ce0caaae8d3cbee36ba83d0a6a641a3a
https://www.frontiersin.org/articles/10.3389/fneur.2021.652590/full
https://www.frontiersin.org/articles/10.3389/fneur.2021.652590/full
Publikováno v:
Science Advances
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::18ccf1aeded92b9cd14c638a4de2ff6b
Publikováno v:
Molecular & Cellular Proteomics
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=r3c4b2081b22::a49bbf3287b1ee1e2585fcdaa5a0e4d0
Autor:
Nils-Göran Larsson, Anna Wedell, David Alsina, Oleksandr Lytovchenko, Camilla Koolmeister, Anna Wredenberg, Aleksandra Schab, Min Jiang, Florian A. Schober, Ilian Atanassov, Robert W. Taylor
Publikováno v:
EMBO Mol Med
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 7, Pp n/a-n/a (2020)
EMBO Molecular Medicine
EMBO Molecular Medicine, Vol 12, Iss 7, Pp n/a-n/a (2020)
Pathogenic variants in FBXL4 cause a severe encephalopathic syndrome associated with mtDNA depletion and deficient oxidative phosphorylation. To gain further insight into the enigmatic pathophysiology caused by FBXL4 deficiency, we generated homozygo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d8c1c8c80178245f893319677f6f11d3
https://hdl.handle.net/21.11116/0000-000B-30A6-3
https://hdl.handle.net/21.11116/0000-000B-30A6-3