Zobrazeno 1 - 10
of 85
pro vyhledávání: '"Florian, Steinberg"'
Autor:
Simon Zenke, Mauricio P. Sica, Florian Steinberg, Julia Braun, Alicia Zink, Alina Gavrilov, Alexander Hilger, Aditya Arra, Monika Brunner-Weinzierl, Roland Elling, Niklas Beyersdorf, Tim Lämmermann, Cristian R. Smulski, Jan C. Rohr
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
A number of costimulatory signals are critical to the activation and regulation of T cells, but how the availability or self-regulation of these occurs was previously unclear. Here the authors show a difference in the fate of ligands trogocytosed by
Externí odkaz:
https://doaj.org/article/36d473209bd24a689eb077a758720e5b
Autor:
Stéphanie Kaeser-Pebernard, Christine Vionnet, Muriel Mari, Devanarayanan Siva Sankar, Zehan Hu, Carole Roubaty, Esther Martínez-Martínez, Huiyuan Zhao, Miguel Spuch-Calvar, Alke Petri-Fink, Gregor Rainer, Florian Steinberg, Fulvio Reggiori, Jörn Dengjel
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-21 (2022)
mTORC1 is a master regulator of cell growth with well-known functions in inhibiting autophagic vesicle formation. Here, the authors show that mTORC1 also affects Golgi architecture and vesicle secretion by phosphorylating the scaffold protein SCYL1.
Externí odkaz:
https://doaj.org/article/47fafe05ef1d4bfc9dcefd8a49f743f9
Autor:
Stephanie Ketterer, Julia Mitschke, Anett Ketscher, Manuel Schlimpert, Wilfried Reichardt, Natascha Baeuerle, Maria Elena Hess, Patrick Metzger, Melanie Boerries, Christoph Peters, Bernd Kammerer, Tilman Brummer, Florian Steinberg, Thomas Reinheckel
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-18 (2020)
The lysosomal aspartic protease Cathepsin D (CTSD) is associated with breast cancer progression. Here the authors show that selective inactivation of CTSD in mammary epithelium delays tumor onset due to impaired mTORC1 signaling, but resumes malignan
Externí odkaz:
https://doaj.org/article/081372ca21394e578d2d46c800e56a5a
Autor:
Bruce M. Kapron, Florian Steinberg
Publikováno v:
Electronic Proceedings in Theoretical Computer Science, Vol 298, Iss Proc. DICE-FOPARA 2019, Pp 61-73 (2019)
Motivated by recent results of Kapron and Steinberg (LICS 2018) we introduce new forms of iteration on length in the setting of applied lambda-calculi for higher-type poly-time computability. In particular, in a type-two setting, we consider function
Externí odkaz:
https://doaj.org/article/5bf38b2fcad046ae865672332277f9b5
Publikováno v:
Logical Methods in Computer Science, Vol Volume 17, Issue 2 (2021)
We give a number of formal proofs of theorems from the field of computable analysis. Many of our results specify executable algorithms that work on infinite inputs by means of operating on finite approximations and are proven correct in the sense of
Externí odkaz:
https://doaj.org/article/1e7db36ec65b4a80a7b804a0722e9e00
Publikováno v:
Microbial Cell, Vol 3, Iss 11, Pp 565-568 (2016)
Altered mitochondrial activities play an important role in many different human disorders, including cancer and neurodegeneration. At the Freiburg Institute of Advanced Studies (FRIAS) Junior Researcher Conference “One Mitochondrion, Many Diseases
Externí odkaz:
https://doaj.org/article/a0237b9489e7471c8a7b865ba1c6f8ee
Autor:
Ioanna Oikonomidi, Emma Burbridge, Miguel Cavadas, Graeme Sullivan, Blanka Collis, Heike Naegele, Danielle Clancy, Jana Brezinova, Tianyi Hu, Andrea Bileck, Christopher Gerner, Alfonso Bolado, Alex von Kriegsheim, Seamus J Martin, Florian Steinberg, Kvido Strisovsky, Colin Adrain
Publikováno v:
eLife, Vol 7 (2018)
The apical inflammatory cytokine TNF regulates numerous important biological processes including inflammation and cell death, and drives inflammatory diseases. TNF secretion requires TACE (also called ADAM17), which cleaves TNF from its transmembrane
Externí odkaz:
https://doaj.org/article/dd72ba467b7f4c28b545afaea75874eb
Autor:
Florian Steinberg
Publikováno v:
Logical Methods in Computer Science, Vol Volume 13, Issue 3 (2017)
This paper investigates second-order representations in the sense of Kawamura and Cook for spaces of integrable functions that regularly show up in analysis. It builds upon prior work about the space of continuous functions on the unit interval: Kawa
Externí odkaz:
https://doaj.org/article/0120fc515de5447e8b5989a32c2f3e7f
Autor:
Alexandra Hertel, Ludovico Martins Alves, Henrik Dutz, Georg Tascher, Florian Bonn, Manuel Kaulich, Ivan Dikic, Stefan Eimer, Florian Steinberg, Anja Bremm
Publikováno v:
Cell reports. 41(10)
The endosomal-lysosomal system is a series of organelles in the endocytic pathway that executes trafficking and degradation of proteins and lipids and mediates the internalization of nutrients and growth factors to ensure cell survival, growth, and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::296504a707fa0575af054c908bee32c8
https://pubmed.ncbi.nlm.nih.gov/36476874
https://pubmed.ncbi.nlm.nih.gov/36476874
Publikováno v:
Dearq, Iss 6, Pp 54-63 (2010)
Este artículo hace una breve presentación de tres proyectos en Asia, que se constituyen como alternativas capaces de suministrar un desarrollo equitativo para gente que habitaba en asentamientos precarios; representan innovaciones sociales, institu
Externí odkaz:
https://doaj.org/article/ae1fbaba1909443da660101f25f2199c