Epirubicin for the Treatment of Sepsis and Septic Shock (EPOS-1): study protocol for a randomised, placebo-controlled phase IIa dose-escalation trial

Autor: Peter Schlattmann, Thomas Lehmann, Tim Rahmel, Johannes Roth, Peter Kranke, Frank M Brunkhorst, Andreas Greinacher, Patrick Meybohm, Philipp Helmer, Stefan Hagel, Florian Rißner, Michael Bauer, Matthias Gründling, Sven-Olaf Kuhn, Christian Fuchs, Luis Ferreira Moita, Frank Bloos, Matthias Michael, Ulrike Schumacher, Matthias Unterberg, Daniel Thomas-Rüddel, Christiane Helbig, Johannes Ehler, Heiko Schenk, Thomas Köcher, Markus Gräler, Ann-Julika Heger, Sebastian Weis, Karen Dlubatz, Jakob Hammersen, Katja Leonhardt, René Markgraf, Franziska Röstel, Nicole Schwarze, Mariann Städtler, Wolfgang Vivas-Varela, Andre Hagedorn, Andrea Wittkowski, Florian Rumpf, Tobias Haas, Sebastian Hottenrott, Eva Kranke, Marianne Neuf, Anke Reppchen, Daniel Röder, Julius Schmidt

Publikováno v: BMJ Open, Vol 14, Iss 4 (2024)

Introduction Sepsis remains the major cause of death among hospitalised patients in intensive care. While targeting sepsis-causing pathogens with source control or antimicrobials has had a dramatic impact on morbidity and mortality of sepsis patients

Externí odkaz: https://doaj.org/article/61a05aa5bd5545d9812046f23ab53e28

Cytokine Hemoadsorption During Cardiac Surgery Versus Standard Surgical Care for Infective Endocarditis (REMOVE): Results From a Multicenter Randomized Controlled Trial

Autor: Mahmoud Diab, Thomas Lehmann, Wolfgang Bothe, Payam Akhyari, Stephanie Platzer, Daniel Wendt, Antje-Christin Deppe, Justus Strauch, Stefan Hagel, Albrecht Günther, Gloria Faerber, Christoph Sponholz, Marcus Franz, André Scherag, Ilia Velichkov, Miriam Silaschi, Jens Fassl, Britt Hofmann, Sven Lehmann, Rene Schramm, Georg Fritz, Gabor Szabo, Thorsten Wahlers, Klaus Matschke, Artur Lichtenberg, Mathias W. Pletz, Jan F. Gummert, Friedhelm Beyersdorf, Christian Hagl, Michael A. Borger, Michael Bauer, Frank M. Brunkhorst, Torsten Doenst, Jan F Gummert, Isabella Schiller, Marcus Winter, Cornelia Eichhorn, Aicko Helbig, Florian Rißner, Kubanychbek Abdyvasiev, Alexandros Moschovas, Sebastian Freiburger, Rauf Safarov, Steffen Bargenda, Hristo Kirov, Markus Richter, Tim Sandhaus, Natig Zeynalov, Mirko Kaluza, Denis Bösemann, Swen Boog, Romanus Ostermann, P. Christian Schulze, Ali Hamadanchi, Rita Musleh, Otto W. Witte, Petra Bloos, Katrin Schwope, Steffi Kolanos, Karina Knuhr-Kohlberg, Anja Haucke, Katja Lehmann-Pohl, Carolyn Weber, Amila Cizmic, Corinna Grathwohl, Dirk Sindhu, Markus Schaschek, Axel Baier, Sebastian Schaub, Uwe Großkurth, Eranya Sone Herré, Andrey Vlasov, Dimitry Podanev, Tobias Plettenberg, Thomas Mühlbauer, Irawati Tunggal, Madlen Eichler, Jasmina Cosic, Vera Wolf, Petra Krause, Stephanie Krischer, Matthias Thielmann, Ingo Wiese, Tobias Hillmer, Jörg von Manstein, Markus Deus, Dusko Ljesic, Daniel Roloff, Tim Alabowicz Wolfgang Ristau, Gina Spangel, Johannes Kroll, Fatos Ballazhi, Stoyan Kondov, Matthias Siepe, Bartosz Rylski, Johannes Scheumann, Matthias D’Inka, Matthias Eschenhagen, Yasir Al-Hamami, Nils Bauer, Martin Thoma, Albena Rambach, Christian Ziemann, Gustavo Fernandez Baca Garcia, Julia Morlock, Christoph Benk, Alina Klink, Christoph Maltes, Gabriele Lechner, Veronika Blümel, Ulrike Heizmann, Priscilla Kotzjan, Peter Haldenwang, Mahmoud Elghannam, Dritan Useini, Dirk Buchwald, Bärbel Buchwald, Thomas Schröter, Christian Binner, Philipp Hartung, David Holzhey, Martin Misfeld, Christian Etz, Piroze Davierwala, Sergey Leontyev, Bettina Pfannmüller, Jens Garbade, Konstantin von Aspern, Diyar Saeed, Muhammed Aydin, Jonathan Herzfeld, Stefan Feder, Philipp Kiefer, Anna Meyer, Joerg Seeburger, Philipp Münch, Jörg Prehl, René Ginther, Josephine Koch, Salome Hecht, Hannes Winkler, Berit Fritzsche, Johann Winata, Julia Schmidt, Jakob Labus, Isabell Frei, Volker Schmidt, Katrin Plötze, Susanne Schal, Moritz Immohr, Yukiharu Sugimura, Anne Gietmann, Andreas Simm, Florian Höpfner, Markus Stiller, Kathrin Ludwig, Sven Helms, Jakub Sunavsky, Julia Götte, Markus Rudloff, Andrea Schönbrodt, Swetlana Fink, Ina-Maria Albrecht, Alice Huguette Minko Nnanga, Carola Schneider, Heike Schilling, Tanja Maier, Ralf-Uwe Kühnel, Stelios Ioannou, Anna-Maria Necaev, Torsten Müller, Ralph Bienek, Hendrik Treede, Zaki Kohistani, Touraj Ahmadpour, Sonja Friese, Andreas Oberbach, Maximilian Luehr, Dominik Joskowiak, Joscha Büch

Publikováno v: Circulation. 145(13)

Background: Cardiac surgery often represents the only treatment option in patients with infective endocarditis (IE). However, IE surgery may lead to a sudden release of inflammatory mediators, which is associated with postoperative organ dysfunction.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3486763560dee396e630e5296a19fc5b
https://pubmed.ncbi.nlm.nih.gov/35213213

Hospital-wide ELectronic medical record evaluated computerised decision support system to improve outcomes of Patients with staphylococcal bloodstream infection (HELP): study protocol for a multicentre stepped-wedge cluster randomised trial

Autor: Jens Vorwerk, Florian Rißner, Marc Fabian Juzek-Küpper, Thomas Wendt, Margarethe Konik, Henner M Kruse, Eric Thomas, Mathias W. Pletz, Susanne Müller, Peter-Michael Rath, Andreas Dürschmid, Oliver Witzke, Saskia Deffge, Silke Haferkamp, Sebastian Wendt, Lo An Phan-Vogtmann, Julia Gantner, Stephan M. Jonas, Norman Lippmann, Daniel Tiller, Kutaiba Saleh, Rainer Röhrig, Stefan Moritz, Andrew J Heidel, André Scherag, Claudia Fischer, Christoph Lübbert, Jonas Schulte-Coerne, Alexander Helhorn, Henning Trawinski, Jonas Fortmann, Cord Spreckelsen, Danny Ammon, Stefan Hagel

Publikováno v: BMJ Open

IntroductionStaphylococci are the most commonly identified pathogens in bloodstream infections. Identification of Staphylococcus aureus in blood culture (SAB) requires a prompt and adequate clinical management. The detection of coagulase-negative sta

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::151832766cfa85c8d2b165fcf2557111
https://pubmed.ncbi.nlm.nih.gov/32047014

The Thuringian registry for bloodstream infections, antibiotic resistance and the practice of blood culture sampling—AlertsNet

Autor: Florian Rißner, Roland P. H. Schmitz, Frank M. Brunkhorst

Publikováno v: International Journal of Antimicrobial Agents. 46:S5-S9

Evidence-based blood culture (BC) testing is of utmost importance for intensive care unit (ICU) patients suspected for sepsis. Knowledge of the aetiological agent and its susceptibility to anti-infective agents enables the clinician to initiate appro

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b298f3393e3f116d8a24406a16ccfcf2
https://doi.org/10.1016/j.ijantimicag.2015.10.004

Extra length of stay and costs because of health care-associated infections at a German university hospital

Autor: Michael Hartmann, André Scherag, Ross J. Baldessarini, Stefan Hagel, Habibollah Arefian, Frank M. Brunkhorst, Steffen Heublein, Florian Rissner

Publikováno v: American journal of infection control. 44(2)

Background Health care–associated infections (HAIs) can be associated with increased health care costs. We examined extra length of hospital stay (LOS) and associated per diem costs attributable to HAIs in a large academic medical center. Methods D

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ccaba0a56a0951025bd5ec868870aeb8
https://pubmed.ncbi.nlm.nih.gov/26521700