Zobrazeno 1 - 10
of 59
pro vyhledávání: '"Florian, Perner"'
Autor:
Nuria Tubío-Santamaría, Ashok Kumar Jayavelu, Tina M. Schnoeder, Theresa Eifert, Chen-Jen Hsu, Florian Perner, Qirui Zhang, Daniela V. Wenge, Fynn M. Hansen, Joanna M. Kirkpatrick, Nidhi Jyotsana, Steven W. Lane, Björn von Eyss, Aniruddha J. Deshpande, Michael W. M. Kühn, Juerg Schwaller, Clemens Cammann, Ulrike Seifert, Frédéric Ebstein, Elke Krüger, Andreas Hochhaus, Michael Heuser, Alessandro Ori, Matthias Mann, Scott A. Armstrong, Florian H. Heidel
Publikováno v:
Molecular Cancer, Vol 22, Iss 1, Pp 1-21 (2023)
Abstract Pharmacologic targeting of chromatin-associated protein complexes has shown significant responses in KMT2A-rearranged (KMT2A-r) acute myeloid leukemia (AML) but resistance frequently develops to single agents. This points to a need for thera
Externí odkaz:
https://doaj.org/article/32a44bd3490c43d78d23fc64b13aaac5
Autor:
Florian Perner, Homa Rahnamoun, Daniela V. Wenge, Yijun Xiong, Athina Apazidis, Disha Anand, Charlie Hatton, Yanhe Wen, Shengqing Gu, X Shirley Liu, Wenbin Xiao, Sheng F. Cai, Ross L. Levine, Gerard M. Mcgeehan, Scott A. Armstrong
Publikováno v:
HemaSphere, Vol 7, p e6233123 (2023)
Externí odkaz:
https://doaj.org/article/576f5a4c6dfd45daabbe17b293ba2228
Autor:
Florian Perner
Publikováno v:
Haematologica, Vol 107, Iss 8 (2021)
Externí odkaz:
https://doaj.org/article/868b476590804a2fb05012475f52edf9
Autor:
Caroline Perner, Florian Perner, Nayana Gaur, Silke Zimmermann, Otto W. Witte, Florian H. Heidel, Julian Grosskreutz, Tino Prell
Publikováno v:
Journal of Neuroinflammation, Vol 16, Iss 1, Pp 1-5 (2019)
Abstract Background Parkinson’s disease (PD) is a progressive neurodegenerative disease characterized by motor and non-motor symptoms. There is increasing evidence that PD pathology is accompanied by an inflammatory response. This is highly relevan
Externí odkaz:
https://doaj.org/article/1ae7a00bc0334c70909c356305537752
Publikováno v:
Molecular & Cellular Oncology, Vol 8, Iss 2 (2021)
While Janus-kinase (JAK)-inhibitors effectively reduce the inflammatory phenotype of myeloproliferative neoplasms (MPN), they do not affect disease burden or presence of the mutated clone to a major extent. Here, we show how Janus-kinase 2 (JAK2)-mut
Externí odkaz:
https://doaj.org/article/456df2cfe6ca47dab91567fd6162afef
Autor:
Ghayas C. Issa, Ibrahim Aldoss, John DiPersio, Branko Cuglievan, Richard Stone, Martha Arellano, Michael J. Thirman, Manish R. Patel, David S. Dickens, Shalini Shenoy, Neerav Shukla, Hagop Kantarjian, Scott A. Armstrong, Florian Perner, Jennifer A. Perry, Galit Rosen, Rebecca G. Bagley, Michael L. Meyers, Peter Ordentlich, Yu Gu, Vinit Kumar, Steven Smith, Gerard M. McGeehan, Eytan M. Stein
Publikováno v:
Nature. 615:920-924
Targeting critical epigenetic regulators reverses aberrant transcription in cancer, thereby restoring normal tissue function1–3. The interaction of menin with lysine methyltransferase 2A (KMT2A), an epigenetic regulator, is a dependence in acute le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb9ceb0202f73dbb3b711cc570b8af1a
https://doi.org/10.1038/s41586-023-05812-3
https://doi.org/10.1038/s41586-023-05812-3
Autor:
Florian Perner, Eytan M. Stein, Daniela V. Wenge, Sukrit Singh, Jeonghyeon Kim, Athina Apazidis, Homa Rahnamoun, Disha Anand, Christian Marinaccio, Charlie Hatton, Yanhe Wen, Richard M. Stone, David Schaller, Shoron Mowla, Wenbin Xiao, Holly A. Gamlen, Aaron J. Stonestrom, Sonali Persaud, Elizabeth Ener, Jevon A. Cutler, John G. Doench, Gerard M. McGeehan, Andrea Volkamer, John D. Chodera, Radosław P. Nowak, Eric S. Fischer, Ross L. Levine, Scott A. Armstrong, Sheng F. Cai
Publikováno v:
Nature. 615:913-919
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::529a1290f87e2b32700e09fe206165c1
https://doi.org/10.1038/s41586-023-05755-9
https://doi.org/10.1038/s41586-023-05755-9
Autor:
Caroline Perner, Florian Perner, Beatrice Stubendorff, Martin Förster, Otto W. Witte, Florian H. Heidel, Tino Prell, Julian Grosskreutz
Publikováno v:
Journal of Neuroinflammation, Vol 15, Iss 1, Pp 1-5 (2018)
Abstract Amyotrophic lateral sclerosis (ALS) is rapidly progressive adult-onset motor neuron disease characterized by the neurodegeneration of both upper and lower motor neurons in the cortex and the spinal cord; the majority of patients succumb to r
Externí odkaz:
https://doaj.org/article/c44d94a93df3435b85631526c851e974
Autor:
Hannah J. Uckelmann, Elena L. Haarer, Reina Takeda, Eric M. Wong, Charlie Hatton, Christian Marinaccio, Florian Perner, Masooma Rajput, Noa J.C. Antonissen, Yanhe Wen, Lu Yang, Lorenzo Brunetti, Chun-Wei Chen, Scott A. Armstrong
Publikováno v:
Cancer Discovery. 13:746-765
The dysregulation of developmental and stem cell–associated genes is a common phenomenon during cancer development. Around half of patients with acute myeloid leukemia (AML) express high levels of HOXA cluster genes and MEIS1. Most of these AML cas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b913b2bcd54fa923346b6564cf152c03
https://doi.org/10.1158/2159-8290.cd-22-0366
https://doi.org/10.1158/2159-8290.cd-22-0366
Autor:
Yadira M. Soto-Feliciano, Francisco J. Sánchez-Rivera, Florian Perner, Douglas W. Barrows, Edward R. Kastenhuber, Yu-Jui Ho, Thomas Carroll, Yijun Xiong, Disha Anand, Alexey A. Soshnev, Leah Gates, Mary Clare Beytagh, David Cheon, Shengqing Gu, X. Shirley Liu, Andrei V. Krivtsov, Maximiliano Meneses, Elisa de Stanchina, Richard M. Stone, Scott A. Armstrong, Scott W. Lowe, C. David Allis
Publikováno v:
Cancer Discovery. 13:146-169
Menin interacts with oncogenic MLL1-fusion proteins, and small molecules that disrupt these associations are in clinical trials for leukemia treatment. By integrating chromatin-focused and genome-wide CRISPR screens with genetic, pharmacologic, and b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae5aebdeae24ecc0935e8aeab3707bed
https://doi.org/10.1158/2159-8290.cd-22-0416
https://doi.org/10.1158/2159-8290.cd-22-0416