Zobrazeno 1 - 10
of 288
pro vyhledávání: '"Florian, Nachon"'
Autor:
Damijan Knez, Daniel Diez-Iriepa, Mourad Chioua, Andrea Gottinger, Milica Denic, Fabien Chantegreil, Florian Nachon, Xavier Brazzolotto, Anna Skrzypczak-Wiercioch, Anže Meden, Anja Pišlar, Janko Kos, Simon Žakelj, Jure Stojan, Kinga Sałat, Julia Serrano, Ana Patricia Fernández, Aitana Sánchez-García, Ricardo Martínez-Murillo, Claudia Binda, Francisco López-Muñoz, Stanislav Gobec, José Marco-Contelles
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2152-2175 (2023)
We describe the development of quinolylnitrones (QNs) as multifunctional ligands inhibiting cholinesterases (ChEs: acetylcholinesterase and butyrylcholinesterase–hBChE) and monoamine oxidases (hMAO-A/B) for the therapy of neurodegenerative diseases
Externí odkaz:
https://doaj.org/article/7f16c8ed45a64b12942b299889a26612
Development of potent reversible selective inhibitors of butyrylcholinesterase as fluorescent probes
Autor:
Stane Pajk, Damijan Knez, Urban Košak, Maja Zorović, Xavier Brazzolotto, Nicolas Coquelle, Florian Nachon, Jacques-Philippe Colletier, Marko Živin, Jure Stojan, Stanislav Gobec
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 35, Iss 1, Pp 498-505 (2020)
Brain butyrylcholinesterase (BChE) is an attractive target for drugs designed for the treatment of Alzheimer’s disease (AD) in its advanced stages. It also potentially represents a biomarker for progression of this disease. Based on the crystal str
Externí odkaz:
https://doaj.org/article/dbf12d5fe8ba43da9d6b77ed1a105af9
Autor:
Clavaguera, Simon, Carella, Alexandre, Caillier, Laurent, Celle, Caroline, Pécaut, Jacques, Lenfant, Stéphane, Vuillaume, Dominique, Simonato, JeanPierre
Publikováno v:
Angewandte Chemie. International Edition; June 2010, Vol. 49 Issue: 24 p4063-4066, 4p
Autor:
Clémence Maupu, Julie Enderlin, Alexandre Igert, Myriam Oger, Stéphane Auvin, Rahma Hassan-Abdi, Nadia Soussi-Yanicostas, Xavier Brazzolotto, Florian Nachon, Grégory Dal Bo, Nina Dupuis
Publikováno v:
Neurobiology of Disease, Vol 152, Iss , Pp 105276- (2021)
Organophosphate pesticides and nerve agents (OPs), are characterized by cholinesterase inhibition. In addition to severe peripheral symptoms, high doses of OPs can lead to seizures and status epilepticus (SE). Long lasting seizure activity and subseq
Externí odkaz:
https://doaj.org/article/a2925ef027ff413ab4ff53a35214c3ee
Autor:
Alexandre Brenet, Julie Somkhit, Rahma Hassan-Abdi, Constantin Yanicostas, Christiane Romain, Olivier Bar, Alexandre Igert, Dominique Saurat, Nicolas Taudon, Gregory Dal-Bo, Florian Nachon, Nina Dupuis, Nadia Soussi-Yanicostas
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-1 (2021)
An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Externí odkaz:
https://doaj.org/article/bdea187ba85c487abbfdef3e3e1e55e3
Autor:
Daniel Chavarria, Ophelie Da Silva, Sofia Benfeito, Sandra Barreiro, Jorge Garrido, Fernando Cagide, Pedro Soares, Fernando Remião, Xavier Brazzolotto, Florian Nachon, Paulo J. Oliveira, José Dias, Fernanda Borges
Publikováno v:
Antioxidants, Vol 10, Iss 2, p 329 (2021)
Neurotransmitter depletion and mitochondrial dysfunction are among the multiple pathological events that lead to neurodegeneration. Following our previous studies related with the development of multitarget mitochondriotropic antioxidants, this study
Externí odkaz:
https://doaj.org/article/7e4c8f8ec8cb43e691f140757bac9eea
Autor:
Janek Bzdrenga, Elodie Trenet, Fabien Chantegreil, Kevin Bernal, Florian Nachon, Xavier Brazzolotto
Publikováno v:
Molecules, Vol 26, Iss 3, p 657 (2021)
Organophosphorous nerve agents (OPNA) pose an actual and major threat for both military and civilians alike, as an upsurge in their use has been observed in the recent years. Currently available treatments mitigate the effect of the nerve agents, and
Externí odkaz:
https://doaj.org/article/f03d1fc962ef4603b1acd1aee3be968e
Autor:
Ophélie Da Silva, Nicolas Probst, Christophe Landry, Anne-Sophie Hanak, Pierre Warnault, Caroline Coisne, André-Guilhem Calas, Fabien Gosselet, Charlotte Courageux, Anne-Julie Gastellier, Marilène Trancart, Rachid Baati, Marie-Pierre Dehouck, Ludovic Jean, Florian Nachon, Pierre-Yves Renard, José Dias
Publikováno v:
Journal of medicinal chemistry. 65(6)
Recent events demonstrated that organophosphorus nerve agents are a serious threat for civilian and military populations. The current therapy includes a pyridinium aldoxime reactivator to restore the enzymatic activity of acetylcholinesterase located
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18b10be7299966ca431e030bdf7e62d4
https://pubmed.ncbi.nlm.nih.gov/35255209
https://pubmed.ncbi.nlm.nih.gov/35255209
Autor:
Filip Pidany, Jana Kroustkova, Abdullah Al Mamun, Daniela Suchankova, Xavier Brazzolotto, Florian Nachon, Fabien Chantegreil, Rafael Dolezal, Lenka Pulkrabkova, Lubica Muckova, Martina Hrabinova, Vladimir Finger, Martin Kufa, Ondrej Soukup, Daniel Jun, Jaroslav Jenco, Jiri Kunes, Lucie Novakova, Jan Korabecny, Lucie Cahlikova
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47298dc2056142171184da1ed33371ba
https://doi.org/10.2139/ssrn.4360512
https://doi.org/10.2139/ssrn.4360512
Autor:
Sofya V. Lushchekina, Gaetan Inidjel, Nicolas Martinez, Patrick Masson, Marie Trovaslet-Leroy, Florian Nachon, Michael Marek Koza, Tilo Seydel, Judith Peters
Publikováno v:
Biomolecules, Vol 10, Iss 12, p 1664 (2020)
The enzyme model, mouse acetylcholinesterase, which exhibits its active site at the bottom of a narrow gorge, was investigated in the presence of different concentrations of sucrose to shed light on the protein and water dynamics in cholinesterases.
Externí odkaz:
https://doaj.org/article/b4e57c4c55a346208e146917c7f97629