Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Florian, Muller"'
Autor:
Jillian E Milanes, Victoria C Yan, Cong-Dat Pham, Florian Muller, Samuel Kwain, Kerrick C Rees, Brian N Dominy, Daniel C Whitehead, Steven W Millward, Madison Bolejack, Roger Shek, Logan Tillery, Isabelle Q Phan, Bart Staker, E Ashley Moseman, Xiang Zhang, Xipeng Ma, Audriy Jebet, Xinmin Yin, James C Morris
Publikováno v:
PLoS Pathogens, Vol 20, Iss 8, p e1012412 (2024)
Infections with the pathogenic free-living amoebae Naegleria fowleri can lead to life-threatening illnesses including catastrophic primary amoebic meningoencephalitis (PAM). Efficacious treatment options for these infections are lacking and the morta
Externí odkaz:
https://doaj.org/article/cb6c340b2bff4f6ca9f6beb1b6aa1504
Autor:
Margherita Zamberlan, Amandine Boeckx, Florian Muller, Federica Vinelli, Olivier Ek, Caterina Vianello, Emeline Coart, Keitaro Shibata, Aurélie Christian, Francesca Grespi, Marta Giacomello, Ingrid Struman, Luca Scorrano, Stéphanie Herkenne
Publikováno v:
Journal of Experimental & Clinical Cancer Research, Vol 41, Iss 1, Pp 1-18 (2022)
Abstract Background Mitochondrial fusion and fission proteins have been nominated as druggable targets in cancer. Whether their inhibition is efficacious in triple negative breast cancer (TNBC) that almost invariably develops chemoresistance is unkno
Externí odkaz:
https://doaj.org/article/ef5ee15a1b5a42608f6031e1dae86383
Autor:
Colm P. Roster, Danielle LaVigne, Jillian E. Milanes, Emily Knight, Heidi D. Anderson, Sabrina Pizarro, Elijah M. Harding, Meredith T. Morris, Victoria C. Yan, Cong-Dat Pham, Florian Muller, Samuel Kwain, Kerrick C. Rees, Brian Dominy, Daniel C. Whitehead, Md Nasir Uddin, Steven W. Millward, James C. Morris
Publikováno v:
Pathogens, Vol 12, Iss 11, p 1290 (2023)
Glucose metabolism is critical for the African trypanosome, Trypanosoma brucei, serving as the lone source of ATP production for the bloodstream form (BSF) parasite in the glucose-rich environment of the host blood. Recently, phosphonate inhibitors o
Externí odkaz:
https://doaj.org/article/2fce50c159fa411eb6a7644d59c82260
Autor:
Sunada Khadka, Kenisha Arthur, Yasaman Barekatain, Eliot Behr, Mykia Washington, Jeffrey Ackroyd, Kaitlyn Crowley, Pornpa Suriyamongkol, Yu-Hsi Lin, Cong-Dat Pham, Rafal Zielinski, Marissa Trujillo, James Galligan, Dimitra K. Georgiou, John Asara, Florian Muller
Publikováno v:
Cancer & Metabolism, Vol 9, Iss 1, Pp 1-17 (2021)
Abstract Background Reprogramming of metabolic pathways is crucial to satisfy the bioenergetic and biosynthetic demands and maintain the redox status of rapidly proliferating cancer cells. In tumors, the tricarboxylic acid (TCA) cycle generates biosy
Externí odkaz:
https://doaj.org/article/519bfa2cafdc47bf912b8bcc970dfde2
Autor:
Makon‐Sébastien Njock, Tina O'Grady, Olivier Nivelles, Michelle Lion, Sophie Jacques, Maureen Cambier, Stephanie Herkenne, Florian Muller, Aurélie Christian, Claire Remacle, Julien Guiot, Souad Rahmouni, Franck Dequiedt, Ingrid Struman
Publikováno v:
Journal of Extracellular Vesicles, Vol 11, Iss 6, Pp n/a-n/a (2022)
Abstract Tumour‐derived extracellular vesicles (EVs) participate in tumour progression by deregulating various physiological processes including angiogenesis and inflammation. Here we report that EVs released by endothelial cells in a mammary tumou
Externí odkaz:
https://doaj.org/article/c205c24080974fa2b434d3dd1a15aa46
Autor:
Jaemyun Kim, Seungwon Ji, Jin-Young Lee, Jean Lorquin, Barbora Orlikova-Boyer, Claudia Cerella, Aloran Mazumder, Florian Muller, Mario Dicato, Olivier Detournay, Marc Diederich
Publikováno v:
Marine Drugs, Vol 21, Iss 4, p 233 (2023)
Palytoxin is considered one of the most potent biotoxins. As palytoxin-induced cancer cell death mechanisms remain to be elucidated, we investigated this effect on various leukemia and solid tumor cell lines at low picomolar concentrations. As palyto
Externí odkaz:
https://doaj.org/article/dc0f952db529426c888e603cf53e66b2
Publikováno v:
Biomolecules, Vol 12, Iss 9, p 1323 (2022)
Coenzyme A (CoA) is an essential co-factor at the intersection of diverse metabolic pathways. Cellular CoA biosynthesis is regulated at the first committed step—phosphorylation of pantothenic acid—catalyzed by pantothenate kinases (PANK1,2,3 in h
Externí odkaz:
https://doaj.org/article/3e2eb3fd9d214203bac1035e38f11586
Autor:
Mayinuer Maitituoheti, Emily Z. Keung, Ming Tang, Liang Yan, Hunain Alam, Guangchun Han, Anand K. Singh, Ayush T. Raman, Christopher Terranova, Sharmistha Sarkar, Elias Orouji, Samir B. Amin, Sneha Sharma, Maura Williams, Neha S. Samant, Mayura Dhamdhere, Norman Zheng, Tara Shah, Amiksha Shah, Jacob B. Axelrad, Nazanin E. Anvar, Yu-Hsi Lin, Shan Jiang, Edward Q. Chang, Davis R. Ingram, Wei-Lien Wang, Alexander Lazar, Min Gyu Lee, Florian Muller, Linghua Wang, Haoqiang Ying, Kunal Rai
Publikováno v:
Cell Reports, Vol 33, Iss 3, Pp 108293- (2020)
Summary: Histone methyltransferase KMT2D harbors frequent loss-of-function somatic point mutations in several tumor types, including melanoma. Here, we identify KMT2D as a potent tumor suppressor in melanoma through an in vivo epigenome-focused poole
Externí odkaz:
https://doaj.org/article/c36af48cd2dc464096d008d1f2795abf
Autor:
Seth T. Gammon, Federica Pisaneschi, Madhavi L. Bandi, Melinda G. Smith, Yuting Sun, Yi Rao, Florian Muller, Franklin Wong, John De Groot, Jeffrey Ackroyd, Osama Mawlawi, Michael A. Davies, Y.N. Vashisht Gopal, M. Emilia Di Francesco, Joseph R. Marszalek, Mark Dewhirst, David Piwnica-Worms
Publikováno v:
Cells, Vol 8, Iss 12, p 1487 (2019)
Tumors lack a well-regulated vascular supply of O2 and often fail to balance O2 supply and demand. Net O2 tension within many tumors may not only depend on O2 delivery but also depend strongly on O2 demand. Thus, tumor O2 consumption rates may influe
Externí odkaz:
https://doaj.org/article/80e43aa655ad4afda9d992b8b65f87d1
Puromycin is an amino nucleoside that inhibits protein synthesis by interrupting elongation of nascent peptide chains. It is a commonly used selection antibiotic in molecular biology research via engineered expression of a puromycin resistance transg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f595b058b0819c6b745c5ccf5c8fa44b
https://doi.org/10.1101/2022.09.06.506844
https://doi.org/10.1101/2022.09.06.506844