Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Florian, Kreuder"'
Autor:
James Lever, Florian Kreuder, Jason Henry, Andrew Hung, Pierre-Marie Allard, Robert Brkljača, Colin Rix, Aya C. Taki, Robin B. Gasser, Jan Kaslin, Donald Wlodkowic, Jean-Luc Wolfender, Sylvia Urban
Publikováno v:
Marine Drugs, Vol 20, Iss 9, p 554 (2022)
Many targeted natural product isolation approaches rely on the use of pre-existing bioactivity information to inform the strategy used for the isolation of new bioactive compounds. Bioactivity information can be available either in the form of prior
Externí odkaz:
https://doaj.org/article/0b365bf039a049018bffc8d219f672c5
Publikováno v:
Zebrafish. 19:32-35
Large-scale chemobehavioral phenotyping with zebrafish embryos is a promising avenue for accelerated neurotoxicity testing and discovery of behavior-modifying neuroceuticals. These strategies are hampered by lack of effective embryo in-test positioni
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f85820e6872169dc46c37897410dea5
https://doi.org/10.1089/zeb.2021.0072
https://doi.org/10.1089/zeb.2021.0072
Autor:
Alon M Douek, Abbas Salavaty, Florian Kreuder, Sebastian-Alexander Stamatis, Joel R Steele, Iresha Hanchapola, Anup D Shah, Ralf B Schittenhelm, Mirana Ramialison, Peter D Currie, Jan Kaslin
Mucopolysaccharidoses are lysosomal storage diseases that collectively represent a major cause of lethal, treatment-refractory childhood dementias 1–7 Clinically-useful interventions are hampered due to an incomplete understanding of their neuropat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0f6830f198a248d2772208598c3f9520
https://doi.org/10.1101/2022.10.03.510585
https://doi.org/10.1101/2022.10.03.510585
Publikováno v:
International journal of molecular sciences. 23(16)
Due to increasing numbers of anthropogenic chemicals with unknown neurotoxic properties, there is an increasing need for a paradigm shift toward rapid and higher throughput behavioral bioassays. In this work, we demonstrate application of a purpose-b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::310b8113ed9a2b48690c04e3f9f065a2
https://pubmed.ncbi.nlm.nih.gov/36012255
https://pubmed.ncbi.nlm.nih.gov/36012255
Publikováno v:
Environmental pollution (Barking, Essex : 1987). 314
Due to technical limitations, there have been minimal studies performed on thermal preferences and thermotactic behaviors of aquatic ectotherm species commonly used in ecotoxicity testing. In this work, we demonstrate an innovative, purpose-built and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad18710e0468094df442c6373b02f9e9
https://pubmed.ncbi.nlm.nih.gov/36169081
https://pubmed.ncbi.nlm.nih.gov/36169081
Autor:
Sebastian-Alexander Stamatis, Minna-Liisa Änkö, Jason Henry, Alon M. Douek, Mitra Khabooshan, Florian Kreuder, Jan Kaslin, Donald Wlodkowic, Georg Ramm
Publikováno v:
International Journal of Molecular Sciences
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 5948, p 5948 (2021)
Volume 22
Issue 11
International Journal of Molecular Sciences, Vol 22, Iss 5948, p 5948 (2021)
Mucopolysaccharidosis IIIA (MPS IIIA, Sanfilippo syndrome type A), a paediatric neurological lysosomal storage disease, is caused by impaired function of the enzyme N-sulfoglucosamine sulfohydrolase (SGSH) resulting in impaired catabolism of heparan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3dc56af47e14587a37c7fb7b49a31682
https://trepo.tuni.fi/handle/10024/142583
https://trepo.tuni.fi/handle/10024/142583
Autor:
Alina Kurolap, Florian Kreuder, Claudia Gonzaga-Jauregui, Morasha Plesser Duvdevani, Tamar Harel, Luna Tammer, Baozhong Xin, Somayeh Bakhtiari, James Rice, Clare L. van Eyk, Jozef Gecz, Jean K. Mah, Derek Atkinson, Heidi Cope, Jennifer A. Sullivan, Alon M. Douek, Daniel Colquhoun, Jason Henry, Donald Wlodkowic, Yesim Parman, Ayşe Candayan, Elif Kocasoy-Orhan, Anat Ilivitzki, Shiri Soudry, Rina Leibu, Fabian Glaser, Valerie Sency, Gil Ast, Vandana Shashi, Michael C. Fahey, Esra Battaloğlu, Albena Jordanova, Vardiella Meiner, A. Micheil Innes, Heng Wang, Orly Elpeleg, Michael C. Kruer, Jan Kaslin, Hagit Baris Feldman
Publikováno v:
Am J Hum Genet
The American journal of human genetics
The American journal of human genetics
Cell adhesion molecules are membrane-bound proteins predominantly expressed in the central nervous system along principal axonal pathways with key roles in nervous system development, neural cell differentiation and migration, axonal growth and guida
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::728e55ef43dca6709d1765690d9d96c9
https://pubmed.ncbi.nlm.nih.gov/35108495
https://pubmed.ncbi.nlm.nih.gov/35108495
Autor:
Alon M, Douek, Mitra, Amiri Khabooshan, Jason, Henry, Sebastian-Alexander, Stamatis, Florian, Kreuder, Georg, Ramm, Minna-Liisa, Änkö, Donald, Wlodkowic, Jan, Kaslin
Publikováno v:
International Journal of Molecular Sciences
Mucopolysaccharidosis IIIA (MPS IIIA, Sanfilippo syndrome type A), a paediatric neurological lysosomal storage disease, is caused by impaired function of the enzyme N-sulfoglucosamine sulfohydrolase (SGSH) resulting in impaired catabolism of heparan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::790271bcd5174cb996bea00e1b7c2584
https://pubmed.ncbi.nlm.nih.gov/34073041
https://pubmed.ncbi.nlm.nih.gov/34073041
Autor:
Serdal Güngör, Benita Grossmann, Bethany Y. Norton, Zubair M. Ahmed, Wendy K. Chung, John Neidhardt, Julie S. Cohen, Elodie Richard, Yoel Hirsch, Jiankang Li, Jozef Gecz, Ralf A. Husain, Saima Riazuddin, Maria J. Guillen Sacoto, Claudia Steen, Andreas Ziegler, G. Christoph Korenke, Dominic Lenz, Mahim Jain, Urania Kotzaeridou, Henry Houlden, Theresa Brunet, Yavuz Oktay, Semra Hiz, Patricia Cornejo, Sheetal Shetty, Alastair H. MacLennan, Nazira Zharkinbekova, Bader Alhaddad, Dani L. Webber, Mary Alice Abbott, Hanns Lochmüller, Rauan Kaiyrzhanov, Melissa Yelton, Cecilia Mancini, Hakon Hakonarson, Amy Crunk, Simona Amenta, Yiran Guo, Jan Kaslin, Clare L. van Eyk, Richard Webster, Arianna Tucci, Alex M. Pagnozzi, Robert B. Hufnagel, Kirsty McWalter, Sandra M. Nordlie, Kaya Bilguvar, Pasquale Striano, Matias Wagner, Florian Kreuder, Lisa Worgan, Ashley P.L. Marsh, Anna Chassevent, Warren A. Marks, James Liu, Brandon S. Guida, Maria Margherita Mancardi, Kelly Harper, Lance H. Rodan, Rhonda E. Schnur, Dianela Judith Claps Sepulveda, Tzvi Weiden, Michele Pinelli, Marion Rapp, Helen Magee, Jesia G. Berry, Aboulfazl Rad, Michael C. Kruer, Mark A. Corbett, Rita Horvath, Constance Smith-Hicks, Joseph Ekstein, Marta Owczarek-Lipska, Somayeh Bakhtiari, Heinrich Sticht, Thomas Meitinger, Anne M. Comi, Alyssa Blesson, Iris Marquardt, Francesca Clementina Radio, Sergio Padilla-Lopez, Giuseppe Marangi, Christine Makowski, Mona Grimmel, Marco Tartaglia, Sheng Chih Jin, Federico Zara, Andreas Hahn, Shrikant Mane, Michael C Fahey, Marcella Zollino, Barbara Vona, Peter D. Turnpenny, Manuela Morleo, Ute Grasshoff, Amber Begtrup, Richard E. Person, Annalaura Torella, Alexander Münchau, Vincenzo Nigro, Reza Maroofian, John Christodoulou, Tobias B. Haack, Vincenzo Salpietro
Publikováno v:
Am. J. Hum. Genet. 108, 2006-2016 (2021)
Am J Hum Genet
Am J Hum Genet
Spermatogenesis-associated 5 like 1 (SPATA5L1) represents an orphan gene encoding a protein of unknown function. We report 28 bi-allelic variants in SPATA5L1 associated with sensorineural hearing loss in 47 individuals from 28 (26 unrelated) families
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1887f7ac3875dcbc64050199115f63ee
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63291
https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=63291
Autor:
Mario Looso, Sorin Tunaru, Christian S. M. Helker, Jens Preussner, Remy Bonnavion, Hyouk-Bum Kwon, Oskar Skog, Sri-Teja Mullapudi, Francesca M. Spagnoli, Florian Kreuder, Joseph J. Lancman, Stefan Offermanns, Didier Y.R. Stainier, P. Duc Si Dong, Laura Mueller, Olle Korsgren
Publikováno v:
Development
Helker, C S M, Mullapudi, S, Mueller, L M, Preussner, J, Tunaru, S, Skog, O, Kwon, H, Kreuder, F, Lancman, J J, Bonnavion, R, Dong, P D S, Looso, M, Offermanns, S, Korsgren, O, Spagnoli, F M & Stainier, D Y R 2019, ' A whole organism small molecule screen identifies novel regulators of pancreatic endocrine development ', Development (Cambridge): for advances in developmental biology and stem cells, vol. 146, no. 14, dev172569, pp. dev.172569 . https://doi.org/10.1242/dev.172569
Helker, C S M, Mullapudi, S, Mueller, L M, Preussner, J, Tunaru, S, Skog, O, Kwon, H, Kreuder, F, Lancman, J J, Bonnavion, R, Dong, P D S, Looso, M, Offermanns, S, Korsgren, O, Spagnoli, F M & Stainier, D Y R 2019, ' A whole organism small molecule screen identifies novel regulators of pancreatic endocrine development ', Development (Cambridge): for advances in developmental biology and stem cells, vol. 146, no. 14, dev172569, pp. dev.172569 . https://doi.org/10.1242/dev.172569
An early step in pancreas development is marked by the expression of the Pdx1 transcription factor within the pancreatic endoderm where it is required for the specification of all endocrine cell types. Subsequently, Pdx1 expression becomes restricted
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::693e09f72095dc6a10fb96ed98758a18
https://europepmc.org/articles/PMC6679364/
https://europepmc.org/articles/PMC6679364/