Zobrazeno 1 - 10
of 126
pro vyhledávání: '"Florian, Grahammer"'
Autor:
Ola Al-Diab, Christin Sünkel, Eric Blanc, Rusan Ali Catar, Muhammad Imtiaz Ashraf, Hongfan Zhao, Pinchao Wang, Markus M. Rinschen, Raphaela Fritsche-Guenther, Florian Grahammer, Sebastian Bachmann, Dieter Beule, Jennifer A. Kirwan, Nikolaus Rajewsky, Tobias B. Huber, Dennis Gürgen, Angelika Kusch
Publikováno v:
Biology of Sex Differences, Vol 15, Iss 1, Pp 1-24 (2024)
Abstract Background Sex differences exist in the prevalence and progression of major glomerular diseases. Podocytes are the essential cell-type in the kidney which maintain the physiological blood-urine barrier, and pathological changes in podocyte h
Externí odkaz:
https://doaj.org/article/6486c593796f4fa4bf8ff685f8544f3b
Autor:
João Baltar, Rafael Mendes Miranda, Maria Cabral, Sandra Rebelo, Florian Grahammer, Tobias B. Huber, Carlos Reguenga, Filipe Almeida Monteiro
Publikováno v:
Neural Development, Vol 19, Iss 1, Pp 1-16 (2024)
Abstract The cell-adhesion molecule NEPH1 is required for maintaining the structural integrity and function of the glomerulus in the kidneys. In the nervous system of Drosophila and C. elegans, it is involved in synaptogenesis and axon branching, whi
Externí odkaz:
https://doaj.org/article/523764824a2840bab401d48b78bf9204
Autor:
Malte Ziemann, MD, Monika Lindemann, MD, Michael Hallensleben, MD, Wolfgang Altermann, MD, Karina Althaus, MD, Klemens Budde, MD, Gunilla Einecke, MD, Ute Eisenberger, MD, Andrea Ender, PhD, Thorsten Feldkamp, MD, Florian Grahammer, MD, Martina Guthoff, MD, Christopher Holzmann-Littig, MD, Christian Hugo, MD, Teresa Kauke, MD, Stephan Kemmner, MD, Martina Koch, MD, Nils Lachmann, PhD, Matthias Marget, PhD, Christian Morath, MD, Martin Nitschke, MD, Lutz Renders, MD, Sabine Scherer, MD, Julian Stumpf, MD, Vedat Schwenger, MD, Florian Sommer, MD, Bernd Spriewald, MD, Caner Süsal, MD, Daniel Zecher, MD, Falko M. Heinemann, PhD, Murielle Verboom, PhD
Publikováno v:
Transplantation Direct, Vol 10, Iss 9, p e1680 (2024)
Background. Preformed donor-specific HLA antibodies (DSA) are a well-known risk factor in kidney transplantation. There is still considerable debate, however, about the optimal risk stratification among patients with preformed DSA. Additionally, data
Externí odkaz:
https://doaj.org/article/a67c56e5a200414ea670b837dd582929
Autor:
Alexandra N. Birtasu, Utz H. Ermel, Johanna V. Rahm, Anja Seybert, Benjamin Flottmann, Mike Heilemann, Florian Grahammer, Achilleas S. Frangakis
Publikováno v:
Journal of Structural Biology: X, Vol 10, Iss , Pp 100114- (2024)
The functioning of vertebrate life relies on renal filtration of surplus fluid and elimination of low-molecular-weight waste products, while keeping serum proteins in the blood. In disease, however, there is leak of serum proteins and tracing them to
Externí odkaz:
https://doaj.org/article/6718c41a6286459188f41b765da606f8
Autor:
Moritz Lassé, Jamal El Saghir, Celine C. Berthier, Sean Eddy, Matthew Fischer, Sandra D. Laufer, Dominik Kylies, Arvid Hutzfeldt, Léna Lydie Bonin, Bernhard Dumoulin, Rajasree Menon, Virginia Vega-Warner, Felix Eichinger, Fadhl Alakwaa, Damian Fermin, Anja M. Billing, Akihiro Minakawa, Phillip J. McCown, Michael P. Rose, Bradley Godfrey, Elisabeth Meister, Thorsten Wiech, Mercedes Noriega, Maria Chrysopoulou, Paul Brandts, Wenjun Ju, Linda Reinhard, Elion Hoxha, Florian Grahammer, Maja T. Lindenmeyer, Tobias B. Huber, Hartmut Schlüter, Steffen Thiel, Laura H. Mariani, Victor G. Puelles, Fabian Braun, Matthias Kretzler, Fatih Demir, Jennifer L. Harder, Markus M. Rinschen
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
Abstract Kidney organoids are a promising model to study kidney disease, but their use is constrained by limited knowledge of their functional protein expression profile. Here, we define the organoid proteome and transcriptome trajectories over cultu
Externí odkaz:
https://doaj.org/article/39ed8a12de7946c9bcf28c0777cf6607
Autor:
Shuya Liu, Yu Zhao, Shun Lu, Tianran Zhang, Maja T. Lindenmeyer, Viji Nair, Sydney E. Gies, Guochao Wu, Robert G. Nelson, Jan Czogalla, Hande Aypek, Stephanie Zielinski, Zhouning Liao, Melanie Schaper, Damian Fermin, Clemens D. Cohen, Denis Delic, Christian F. Krebs, Florian Grahammer, Thorsten Wiech, Matthias Kretzler, Catherine Meyer-Schwesinger, Stefan Bonn, Tobias B. Huber
Publikováno v:
Genome Medicine, Vol 15, Iss 1, Pp 1-19 (2023)
Abstract Background Diabetic nephropathy (DN) is the leading cause of end-stage renal disease, and histopathologic glomerular lesions are among the earliest structural alterations of DN. However, the signaling pathways that initiate these glomerular
Externí odkaz:
https://doaj.org/article/df3b8422c172486d90e70dad5e72e7ce
Autor:
Maciej K. Kocylowski, Hande Aypek, Wolfgang Bildl, Martin Helmstädter, Philipp Trachte, Bernhard Dumoulin, Sina Wittösch, Lukas Kühne, Ute Aukschun, Carolin Teetzen, Oliver Kretz, Botond Gaal, Akos Kulik, Corinne Antignac, Geraldine Mollet, Anna Köttgen, Burulca Göcmen, Jochen Schwenk, Uwe Schulte, Tobias B. Huber, Bernd Fakler, Florian Grahammer
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
The slit-diaphragm is a cellular junction that is crucial for blood filtration in the kidney. Kocylowski et al. show that the junction-spanning components are embedded in a protein network for dynamic control of filtration; network disturbance leads
Externí odkaz:
https://doaj.org/article/6b2ce777bb844f689ec4e628b7c40b09
Autor:
Fabian Braun, Ahmed Abed, Dominik Sellung, Manuel Rogg, Mathias Woidy, Oysten Eikrem, Nicola Wanner, Jessica Gambardella, Sandra D. Laufer, Fabian Haas, Milagros N. Wong, Bernhard Dumoulin, Paula Rischke, Anne Mühlig, Wiebke Sachs, Katharina von Cossel, Kristina Schulz, Nicole Muschol, Sören W. Gersting, Ania C. Muntau, Oliver Kretz, Oliver Hahn, Markus M. Rinschen, Michael Mauer, Tillmann Bork, Florian Grahammer, Wei Liang, Thorsten Eierhoff, Winfried Römer, Arne Hansen, Catherine Meyer-Schwesinger, Guido Iaccarino, Camilla Tøndel, Hans-Peter Marti, Behzad Najafian, Victor G. Puelles, Christoph Schell, Tobias B. Huber
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 11 (2023)
Current therapies for Fabry disease are based on reversing intracellular accumulation of globotriaosylceramide (Gb3) by enzyme replacement therapy (ERT) or chaperone-mediated stabilization of the defective enzyme, thereby alleviating lysosomal dysfun
Externí odkaz:
https://doaj.org/article/c82d0427278d4ae092a98644e9de535c
Autor:
Smilla Hofmann, Florian Grahammer, Ilka Edenhofer, Victor G. Puelles, Tobias B. Huber, Jan Czogalla
Publikováno v:
Frontiers in Physiology, Vol 13 (2022)
Kidney transplantation is the only definitive therapy for end-stage kidney disease. The shortage of organs for transplantation is the main limitation of this life-saving treatment. Normothermic machine perfusion (NMP) is a novel preservation techniqu
Externí odkaz:
https://doaj.org/article/7220390c1c9c4decac2d86b4604eceb3
Publikováno v:
Case Reports in Nephrology and Dialysis, Vol 11, Iss 1, Pp 69-77 (2021)
Hyperkalemia is a life-threatening condition potentially leading to cardiac arrest. Here, we report a case of surprising severe hyperkalemia of 10.2 mmol/L in a diabetic patient with previously normal kidney function presenting without discernible cl
Externí odkaz:
https://doaj.org/article/03cf069095b3409bad1471b6ba171bd0