Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Florian, Barthélémy"'
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/99e23d6deecf4d4a969b4fc12d2ded22
Autor:
Deirdre D. Scripture-Adams, Kevin N. Chesmore, Florian Barthélémy, Richard T. Wang, Shirley Nieves-Rodriguez, Derek W. Wang, Ekaterina I. Mokhonova, Emilie D. Douine, Jijun Wan, Isaiah Little, Laura N. Rabichow, Stanley F. Nelson, M. Carrie Miceli
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
A method to isolate and sequence individual nuclei from human and mouse muscle biopsies provides further insight into the mechanisms of dystrophin loss and repair, in the context of Duchenne muscular dystrophy.
Externí odkaz:
https://doaj.org/article/52c54e56cb454536bdffeb1964579512
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Duchenne Muscular Dystrophy (DMD)’s complex multi-system pathophysiology, coupled with the cost-prohibitive logistics of multi-year drug screening and follow-up, has hampered the pursuit of new therapeutic approaches. Here we conducted a systematic
Externí odkaz:
https://doaj.org/article/f5e601e97c20499db387a24adf0cb3d4
Autor:
Shirley Nieves-Rodriguez, Florian Barthélémy, Jeremy D. Woods, Emilie D. Douine, Richard T. Wang, Deirdre D. Scripture-Adams, Kevin N. Chesmore, Francesca Galasso, M. Carrie Miceli, Stanley F. Nelson
Publikováno v:
Frontiers in Genetics, Vol 14 (2023)
Muscle damage and fibro-fatty replacement of skeletal muscles is a main pathologic feature of Duchenne muscular dystrophy (DMD) with more proximal muscles affected earlier and more distal affected later in the disease course, suggesting that differen
Externí odkaz:
https://doaj.org/article/9a27a0c852384f55bc7769d063aa2045
Autor:
Florian Barthélémy, Jeffrey W. Santoso, Laura Rabichow, Rongcheng Jin, Isaiah Little, Stanley F. Nelson, Megan L. McCain, M. Carrie Miceli
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
In vitro models of patient-derived muscle allow for more efficient development of genetic medicines for the muscular dystrophies, which often present mutation-specific pathologies. One popular strategy to generate patient-specific myotubes involves r
Externí odkaz:
https://doaj.org/article/73fc79b089c845ef877ae95d996f78e5
Autor:
Florian Barthélémy, Richard T. Wang, Christopher Hsu, Emilie D. Douine, Eugene E. Marcantonio, Stanley F. Nelson, M. Carrie Miceli
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss , Pp 580-589 (2019)
Systemic delivery of antisense oligonucleotides (AO) for DMD exon skipping has proven effective for reframing DMD mRNA, rescuing dystrophin expression, and slowing disease progression in animal models. In humans with Duchenne muscular dystrophy treat
Externí odkaz:
https://doaj.org/article/226d7e2db31d4f8d878ca8392b88261f
Autor:
Christopher Hsu, Richard T. Wang, M. Carrie Miceli, Stanley F. Nelson, Eugene E. Marcantonio, Emilie D. Douine, Florian Barthélémy
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 18, Iss, Pp 580-589 (2019)
Molecular Therapy. Nucleic Acids
Molecular Therapy. Nucleic Acids
Systemic delivery of antisense oligonucleotides (AO) for DMD exon skipping has proven effective for reframing DMD mRNA, rescuing dystrophin expression, and slowing disease progression in animal models. In humans with Duchenne muscular dystrophy treat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::277262769fe832d60dc2a9549bd636bf
http://www.sciencedirect.com/science/article/pii/S2162253119302677
http://www.sciencedirect.com/science/article/pii/S2162253119302677
Autor:
Philip Doble, Nerida Cole, Stanley F. Nelson, Rachelle H. Crosbie, Jonathan Wanagat, Elizabeth M. Gibbs, M. Carrie Miceli, Florian Barthélémy, Mika T. Westerhausen, Thomas E. Lockwood, David P. Bishop
Publikováno v:
Scientific reports, vol 11, iss 1
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Scientific Reports, Vol 11, Iss 1, Pp 1-11 (2021)
Scientific Reports
Emerging and promising therapeutic interventions for Duchenne muscular dystrophy (DMD) are confounded by the challenges of quantifying dystrophin. Current approaches have poor precision, require large amounts of tissue, and are difficult to standardi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46ab79deae922266e4ba36a083c2365
https://escholarship.org/uc/item/28f1f85p
https://escholarship.org/uc/item/28f1f85p
Autor:
David Segovia, Elizabeth M. Gibbs, Carrie Miceli, Allen Herbst, Rachelle H. Crosbie, Jonathan Wanagat, Cathy C. Lee, Austin Hoang, Florian Barthélémy, Stanley F. Nelson
Publikováno v:
Journal of cytology & histology, vol 11, iss 2
Journal of cytology & histology
Journal of cytology & histology
Background Human muscle biopsies are increasingly important for diagnosis, research, and to monitor therapeutic trials. We examined the use of a self-contained, vacuum-assisted biopsy system and a novel muscle freezing technique to improve, simplify,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f616fda8f9129604aca261d9c47d4a8
https://doi.org/10.37421/jch.2020.11.553
https://doi.org/10.37421/jch.2020.11.553
Autor:
Florian Barthélémy, Nicolas Wein
Publikováno v:
Neuromuscular Disorders. 28:803-824
Dystrophinopathies are diseases caused by mutations in the Duchenne Muscular Dystrophy gene (DMD) encoding the dystrophin protein. Depending on the type of mutation, patients develop either the severe DMD or the milder Becker Muscular Dystrophy. Alth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3df786b4dfb1958a46cbeea7fd1ddb90
https://doi.org/10.1016/j.nmd.2018.06.009
https://doi.org/10.1016/j.nmd.2018.06.009