Výsledky vyhledávání - "Flores, Samuel C."

Akademický článek

Predicting protein ligand binding motions with the conformation explorer

Publikováno v: BMC Bioinformatics, Vol 12, Iss 1, p 417 (2011)

Abstract Background Knowledge of the structure of proteins bound to known or potential ligands is crucial for biological understanding and drug design. Often the 3D structure of the protein is available in some conformation, but binding the ligand of

Externí odkaz: https://doaj.org/article/eab9ba3d6f684c7da5b9fe8724753ee0

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Akademický článek

FlexOracle: predicting flexible hinges by identification of stable domains

Autor: Flores Samuel C, Gerstein Mark B

Publikováno v: BMC Bioinformatics, Vol 8, Iss 1, p 215 (2007)

Abstract Background Protein motions play an essential role in catalysis and protein-ligand interactions, but are difficult to observe directly. A substantial fraction of protein motions involve hinge bending. For these proteins, the accurate identifi

Externí odkaz: https://doaj.org/article/4ba71edd838642859ccdbb6cb71f5a90

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Akademický článek

Hinge Atlas: relating protein sequence to sites of structural flexibility

Autor: Yang Julie, Lu Long J, Flores Samuel C, Carriero Nicholas, Gerstein Mark B

Publikováno v: BMC Bioinformatics, Vol 8, Iss 1, p 167 (2007)

Abstract Background Relating features of protein sequences to structural hinges is important for identifying domain boundaries, understanding structure-function relationships, and designing flexibility into proteins. Efforts in this field have been h

Externí odkaz: https://doaj.org/article/8217e58103464a1aa5171a6d423c83b5

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Akademický článek

Multiscale modeling of macromolecular biosystems.

Autor: Flores, Samuel C., Bernauer, Julie, Shin, Seokmin, Zhou, Ruhong, Huang, Xuhui

Publikováno v: Briefings in Bioinformatics. Jul2012, Vol. 13 Issue 4, p395-405. 11p.

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Structural and Functional Impact of Parkinson Disease-Associated Mutations in the E3 Ubiquitin Ligase Parkin

Autor: Fiesel, Fabienne C., Caulfield, Thomas R., Moussaud-Lamodière, Elisabeth L., Ogaki, Kotaro, Dourado, Daniel F.A.R., Flores, Samuel C., Ross, Owen A., Springer, Wolfdieter

Mutations in the PARKIN/PARK2 gene that result in loss-of-function of the encoded, neuroprotective E3 ubiquitin ligase Parkin cause recessive, familial early-onset Parkinson disease. As an increasing number of rare Parkin sequence variants with uncle

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::7cea5d1ba03bae5b6a2e8f21e236fc7b
https://europepmc.org/articles/PMC4514554/

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Community-wide evaluation of methods for predicting the effect of mutations on protein-protein interactions

Autor: Moretti, Rocco, Fleishman, Sarel J, Agius, Rudi, Torchala, Mieczyslaw, Bates, Paul A., Kastritis, Panagiotis L, Rodrigues, João P. G. L. M., Trellet, Mikael, Bonvin, Alexandre M. J. J., Cui, Meng, Rooman, Marianne, Gillis, Dimitri, Dehouck, Yves, Moal, Iain, Romero-Durana, Miguel, Pérez-Cano, Laura, Pallara, Chiara, Jimenez, Brian, Fernández-Recio, Juan, Flores, Samuel C, Pacella, Michael, Praneeth Kilambi, Krishna, Gray, Jeffrey J, Popov, Petr, Grudinin, Sergei, Esquivel-Rodríguez, Juan, Kihara, Daisuke, Zhao, Nan, Korkin, Dmitry, Zhu, Xiaolei, Demerdash, Omar N A, Mitchell, Julie, Kanamori, Eiji, Tsuchiya, Yuko, Nakamura, Haruki, Lee, Hasup, Park, Hahnbeom, Seok, Chaok, Sarmiento, Jamica, Liang, Shide, Teraguchi, Shusuke, Standley, Daron M, Shimoyama, Hiromitsu, Terashi, Genki, Takeda-Shitaka, Mayuko, Iwadate, Mitsuo, Umeyama, Hideaki, Beglov, Dmitri, Hall, David R, Kozakov, Dima, Vajda, Sandor, Pierce, Brian G, Hwang, Howook, Vreven, Thom, Weng, Zhiping, Huang, Yangyu, Li, Haotian, Yang, Xiufeng, Ji, Xiaofeng, Liu, Shiyong, Xiao, Yi, Zacharias, Martin, Qin, Sanbo, Zhou, Huan-Xiang, Huang, Sheng-You, Zou, Xiaoqin, Velankar, Sameer, Janin, Joel, Wodak, Shoshana J, Baker, David

Publikováno v: Proteins-Structure, Function and Bioinformatics
Proteins-Structure, Function and Bioinformatics, Wiley, 2013, 81 (11), pp.1980-1987. ⟨10.1002/prot.24356⟩
Proteins-Structure, Function and Bioinformatics, 2013, 81 (11), pp.1980-1987. ⟨10.1002/prot.24356⟩

International audience; Community-wide blind prediction experiments such as CAPRI and CASP provide an objective measure of the current state of predictive methodology. Here we describe a community-wide assessment of methods to predict the effects of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::e0f499373ef4adcbf0d3235740fc7a55
https://hal.inria.fr/hal-00905794

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