Human induced pluripotent stem cell based hepatic-modeling of lipid metabolism associated TM6SF2 E167K variant.

Autor: Faccioli LA; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Sun Y; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; School of Medicine, Tsinghua University, Beijing, PRC., Animasahun O; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI., Motomura T; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA., Liu Z; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Kurihara T; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Hu Z; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Yang B; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Cetin Z; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Baratta AM; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA., Shankaran A; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI., Nenwani M; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Altay LN; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI., Huang L; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI., Meurs N; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Franks J; Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA, USA., Stolz D; Center for Biologic Imaging, University of Pittsburgh, Pittsburgh, PA, USA., Gavlock DC; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, USA., Miedel MT; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA.; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA, USA., Ostrowska A; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Florentino RM; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA., Fox IJ; Department of Surgery, Children's Hospital of Pittsburgh of UPMC, University of Pittsburgh, Pittsburgh, PA, USA., Nagrath D; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.; Biointerfaces Institute, University of Michigan, Ann Arbor, MI, USA.; Laboratory for Systems Biology of Human Diseases, University of Michigan, Ann Arbor, MI.; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA., Soto-Gutierrez A; Department of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.; Center for Transcriptional Medicine, University of Pittsburgh, Pittsburgh, PA, USA.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, PA, USA.

Publikováno v: Hepatology (Baltimore, Md.) [Hepatology] 2024 Aug 27. Date of Electronic Publication: 2024 Aug 27.

Polymorphisms Associated With Metabolic Dysfunction-Associated Steatotic Liver Disease Influence the Progression of End-Stage Liver Disease.

Autor: Kocas-Kilicarslan ZN; Department of Pathology, Center for Transcriptional Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Cetin Z; Department of Pathology, Center for Transcriptional Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Faccioli LAP; Department of Pathology, Center for Transcriptional Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Motomura T; Department of Pathology, Center for Transcriptional Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Amirneni S; Department of Pathology, Center for Transcriptional Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Diaz-Aragon R; Department of Pathology, Center for Transcriptional Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Florentino RM; Department of Pathology, Center for Transcriptional Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Sun Y; Department of Pathology, Center for Transcriptional Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; School of Medicine, Tsinghua University, Beijing, China., Pla-Palacin I; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania., Xia M; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania., Miedel MT; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania., Kurihara T; Department of Pathology, Center for Transcriptional Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Hu Z; Department of Pathology, Center for Transcriptional Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania., Ostrowska A; Department of Pathology, Center for Transcriptional Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania., Wang Z; Department of Statistics, University of Pittsburgh, Pittsburgh, Pennsylvania., Constantine R; Discovery Life Sciences, Huntsville, Alabama., Li A; Discovery Life Sciences, Huntsville, Alabama., Taylor DL; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania., Behari J; Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, Pennsylvania., Soto-Gutierrez A; Department of Pathology, Center for Transcriptional Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; University of Pittsburgh Drug Discovery Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.; Pittsburgh Liver Research Center, University of Pittsburgh, Pittsburgh, Pennsylvania.; McGowan Institute for Regenerative Medicine, Pittsburgh, Pennsylvania., Tafaleng EN; Department of Pathology, Center for Transcriptional Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.

Publikováno v: Gastro hep advances [Gastro Hep Adv] 2024; Vol. 3 (1), pp. 67-77. Date of Electronic Publication: 2023 Oct 05.

Human Induced Pluripotent Stem Cell based Hepatic-Modeling of Lipid metabolism associated TM6SF2 E167K variant.

Autor: Faccioli LA, Sun Y, Motomura T, Liu Z, Kurihara T, Hu Z, Cetin Z, Franks J, Stolz D, Ostrowska A, Florentino RM, Fox IJ, Soto-Gutierrez A

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 18. Date of Electronic Publication: 2023 Dec 18.

Evaluation of Human Hepatocyte Drug Metabolism Carrying High-Risk or Protection-Associated Liver Disease Genetic Variants.

Autor: Faccioli LAP; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Cetin Z; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Kocas-Kilicarslan ZN; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Ortiz K; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Sun Y; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Hu Z; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Kurihara T; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Tafaleng EN; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA., Florentino RM; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.; Pittsburgh Liver Research Center, Human Synthetic Liver Biology Core, University of Pittsburgh, Pittsburgh, PA 15261, USA., Wang Z; Department of Statistics, University of Pittsburgh, Pittsburgh, PA 15213, USA., Xia M; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA., Miedel MT; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Computational and Systems Biology, University of Pittsburgh, Pittsburgh, PA 15260, USA., Taylor DL; Pittsburgh Liver Research Center, Human Synthetic Liver Biology Core, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Statistics, University of Pittsburgh, Pittsburgh, PA 15213, USA.; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA., Behari J; Pittsburgh Liver Research Center, Human Synthetic Liver Biology Core, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Department of Medicine, Division of Gastroenterology, Hepatology, and Nutrition, University of Pittsburgh Medical Center, Pittsburgh, PA 15213, USA., Ostrowska A; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.; Pittsburgh Liver Research Center, Human Synthetic Liver Biology Core, University of Pittsburgh, Pittsburgh, PA 15261, USA., Constantine R; Discovery Life Sciences, Huntsville, AL 35806, USA., Li A; Discovery Life Sciences, Huntsville, AL 35806, USA., Soto-Gutierrez A; Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.; Pittsburgh Liver Research Center, Human Synthetic Liver Biology Core, University of Pittsburgh, Pittsburgh, PA 15261, USA.; Drug Discovery Institute, University of Pittsburgh, Pittsburgh, PA 15261, USA.; McGowan Institute for Regenerative Medicine, Pittsburgh, PA 15219, USA.

Publikováno v: International journal of molecular sciences [Int J Mol Sci] 2023 Aug 29; Vol. 24 (17). Date of Electronic Publication: 2023 Aug 29.

Therapeutic treatment with phosphodiesterase-4 inhibitors alleviates kidney injury and renal fibrosis by increasing MMP-9 in a doxorubicin-induced nephrotoxicity mouse model.

Autor: Costa WC; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Beltrami VA; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Campolina-Silva GH; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Queiroz-Junior CM; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Florentino RM; Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Machado JR; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Martins DG; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Gonçalves WA; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Barroso LC; Departamento de Odontologia, Universidade Federal de Minas Gerais, Brazil., Freitas KM; Programa de Pós-graduação em Engenharia de Materiais, Centro Federal de Educação Tecnológica de Minas Gerais (CEFET), Belo Horizonte, Brazil., de Souza-Neto FP; Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Félix FB; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., da Silva RF; Departamento de Fisiologia e Biofísica, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Oliveira CA; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Câmara NOS; Departamento de Imunologia, Instituto de Ciências Biomédicas, Universidade de São Paulo, São Paulo, Brazil., Rachid MA; Departamento de Patologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Teixeira MM; Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil., Rezende BM; Departamento de Enfermagem Básica, Escola de Enfermagem, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address: barbaramaximinorez@gmail.com., Pinho V; Departamento de Morfologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerais, Belo Horizonte, Brazil. Electronic address: vpinho@icb.ufmg.br.

Publikováno v: International immunopharmacology [Int Immunopharmacol] 2023 Feb; Vol. 115, pp. 109583. Date of Electronic Publication: 2023 Jan 05.