Zobrazeno 1 - 10 of 19 pro vyhledávání: '"Florencia Secchiari"'
1
Akademický článek
The MICA-NKG2D axis in clear cell renal cell carcinoma bolsters MICA as target in immuno-oncology
Autor: Florencia Secchiari, Sol Yanel Nuñez, Jessica Mariel Sierra, Andrea Ziblat, María Victoria Regge, Ximena Lucía Raffo Iraolagoitia, Agustín Rovegno, Carlos Ameri, Fernando Pablo Secin, Nicolás Richards, Hernando Ríos Pita, Gonzalo Vitagliano, Luis Rico, Mauro Mieggi, Florencia Frascheri, Nicolás Bonanno, Leandro Blas, Aldana Trotta, Adrián David Friedrich, Mercedes Beatriz Fuertes, Carolina Inés Domaica, Norberto Walter Zwirner
Publikováno v: OncoImmunology, Vol 11, Iss 1 (2022)
NKG2D is a major natural killer (NK) cell-activating receptor that recognizes eight ligands (NKG2DLs), including MICA, and whose engagement triggers NK cell effector functions. As NKG2DLs are upregulated on tumor cells but tumors can subvert the NKG2
Externí odkaz: https://doaj.org/article/1adb248fdaf140c9b28258767763461f
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2
Akademický článek
Tumor-Experienced Human NK Cells Express High Levels of PD-L1 and Inhibit CD8+ T Cell Proliferation
Autor: Jessica M. Sierra, Florencia Secchiari, Sol Y. Nuñez, Ximena L. Raffo Iraolagoitia, Andrea Ziblat, Adrián D. Friedrich, María V. Regge, M. Cecilia Santilli, Nicolás I. Torres, Mariana Gantov, Aldana Trotta, Carlos Ameri, Gonzalo Vitagliano, Hernando Ríos Pita, Luis Rico, Agustín Rovegno, Nicolás Richards, Carolina I. Domaica, Norberto W. Zwirner, Mercedes B. Fuertes
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Natural Killer (NK) cells play a key role in cancer immunosurveillance. However, NK cells from cancer patients display an altered phenotype and impaired effector functions. In addition, evidence of a regulatory role for NK cells is emerging in divers
Externí odkaz: https://doaj.org/article/3d8fa6bbe2054f3f9321c991e500c96a
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3
Akademický článek
Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibitory Phenotype Characterized by Overexpression of CD85j, CD45, CD48 and PD-1
Autor: Andrea Ziblat, Ximena Lucía Raffo Iraolagoitia, Sol Yanel Nuñez, Nicolás Ignacio Torres, Florencia Secchiari, Jessica Mariel Sierra, Raúl Germán Spallanzani, Agustín Rovegno, Fernando Pablo Secin, Mercedes Beatriz Fuertes, Carolina Inés Domaica, Norberto Walter Zwirner
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Although natural killer (NK) cells infiltrate clear cell renal cell carcinomas (ccRCC), the most frequent malignancy of the kidney, tumor progression suggests that they become dysfunctional. As ccRCC-driven subversion of NK cell effector functions is
Externí odkaz: https://doaj.org/article/7fcc502be5bf4a60b9407ff51b56cfca
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4
Akademický článek
Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein
Autor: Nicolas Torres, María Victoria Regge, Florencia Secchiari, Adrián David Friedrich, Raúl Germán Spallanzani, Ximena Lucía Raffo Iraolagoitia, Sol Yanel Núñez, Jessica Mariel Sierra, Andrea Ziblat, María Cecilia Santilli, Nicolás Gilio, Evangelina Almada, Constanza Lauche, Romina Pardo, Carolina Inés Domaica, Mercedes Beatriz Fuertes, Kevin Patrick Madauss, Israel S Gloger, Vanesa Zylberman, Fernando Alberto Goldbaum, Norberto Walter Zwirner
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Background Natural killer and cytotoxic CD8+ T cells are major players during antitumor immunity. They express NKG2D, an activating receptor that promotes tumor elimination through recognition of the MHC class I chain-related proteins A and B (MICA a
Externí odkaz: https://doaj.org/article/60794d6d6f5348769085d3ffeeb174f9
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5
Akademický článek
Interleukin (IL)-23 Stimulates IFN-γ Secretion by CD56bright Natural Killer Cells and Enhances IL-18-Driven Dendritic Cells Activation
Autor: Andrea Ziblat, Sol Y. Nuñez, Ximena Lucía Raffo Iraolagoitia, Raúl German Spallanzani, Nicolás I. Torres, Jessica M. Sierra, Florencia Secchiari, Carolina I. Domaica, Mercedes B. Fuertes, Norberto W. Zwirner
Publikováno v: Frontiers in Immunology, Vol 8 (2018)
Interleukin (IL)-23 is a member of the IL-12 family of cytokines that, as the other members of this family, is secreted by monocytes, macrophages, and dendritic cells (DC) upon recognition of bacterial, viral, and fungal components. IL-23 is critical
Externí odkaz: https://doaj.org/article/cf833740ced44593b8d3ce9d81046f6c
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6
Tumor-Experienced Human NK Cells Express High Levels of PD-L1 and Inhibit CD8+ T Cell Proliferation
Autor: Aldana Trotta, Andrea Ziblat, Gonzalo Vitagliano, Mercedes Beatriz Fuertes, M. Cecilia Santilli, Adrián Friedrich, Carolina Ines Domaica, Carlos Ameri, Mariana Gantov, Hernando Rios Pita, Luis Rico, Sol Yanel Nuñez, Nicolás Richards, Agustin Rovegno, Jessica Mariel Sierra, María Victoria Regge, Florencia Secchiari, Ximena Lucía Raffo Iraolagoitia, Norberto Walter Zwirner, Nicolás Torres
Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Frontiers in Immunology, Vol 12 (2021)
Natural Killer (NK) cells play a key role in cancer immunosurveillance. However, NK cells from cancer patients display an altered phenotype and impaired effector functions. In addition, evidence of a regulatory role for NK cells is emerging in divers
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8860c35d8ade243f41c695f97f09659
https://doi.org/10.3389/fimmu.2021.745939
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7
Circulating and Tumor-Infiltrating NK Cells From Clear Cell Renal Cell Carcinoma Patients Exhibit a Predominantly Inhibitory Phenotype Characterized by Overexpression of CD85j, CD45, CD48 and PD-1
Autor: Agustin Rovegno, Norberto Walter Zwirner, Nicolás Torres, Florencia Secchiari, Andrea Ziblat, Ximena Lucía Raffo Iraolagoitia, Sol Yanel Nuñez, Mercedes Beatriz Fuertes, Carolina Ines Domaica, Jessica Mariel Sierra, Fernando P. Secin, Raul German Spallanzani
Publikováno v: Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Although natural killer (NK) cells infiltrate clear cell renal cell carcinomas (ccRCC), the most frequent malignancy of the kidney, tumor progression suggests that they become dysfunctional. As ccRCC-driven subversion of NK cell effector functions is
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4fab2200ad01e31c8a2f90da0db1c48b
https://www.frontiersin.org/articles/10.3389/fimmu.2021.681615/full
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8
Restoration of antitumor immunity through anti-MICA antibodies elicited with a chimeric protein
Autor: Carolina Ines Domaica, Kenneth W. Hance, Constanza Lauché, Kevin P. Madauss, Florencia Secchiari, Andrea Ziblat, Ximena Lucía Raffo Iraolagoitia, Fernando Alberto Goldbaum, Maria Cecilia Santilli, Nicolas Gilio, Sol Yanel Nuñez, Norberto Walter Zwirner, Evangelina Almada, Adrián Friedrich, Vanesa Zylberman, Mercedes Beatriz Fuertes, Jessica Mariel Sierra, Israel S. Gloger, Raul German Spallanzani, María Victoria Regge, Nicolás Torres, Romina Paola Pardo
Publikováno v: Journal for ImmunoTherapy of Cancer, Vol 8, Iss 1 (2020)
Journal for Immunotherapy of Cancer
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Background Natural killer and cytotoxic CD8+ T cells are major players during antitumor immunity. They express NKG2D, an activating receptor that promotes tumor elimination through recognition of the MHC class I chain-related proteins A and B (MICA a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a807302989d0c0cff85e03dae050930d
https://jitc.bmj.com/content/8/1/e000233.full
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9
CTBP1/CYP19A1/estradiol axis together with adipose tissue impacts over prostate cancer growth associated to metabolic syndrome
Autor: Adriana De Siervi, Juliana Porretti, Flavia Piccioni, Natalia Pascuali, Georgina Daniela Scalise, Colin Clyne, Paula Lucía Farré, Cintia Massillo, Paola De Luca, Kevin Gardner, Guillermo Nicolás Dalton, Florencia Secchiari
Publikováno v: International Journal of Cancer. 144:1115-1127
Metabolic syndrome (MeS) increases prostate cancer (PCa) risk and aggressiveness. C-terminal binding protein 1 (CTBP1) is a transcriptional co-repressor of tumor suppressor genes that is activated by low NAD+ /NADH ratio. Previously, our group establ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bb88a597d73c9f29dc97b493a5f277eb
https://doi.org/10.1002/ijc.31773
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10
Human M2 Macrophages Limit NK Cell Effector Functions through Secretion of TGF-β and Engagement of CD85j
Autor: Sol Yanel Nuñez, Ximena Lucía Raffo Iraolagoitia, Mercedes Beatriz Fuertes, Andrea Ziblat, Carolina Ines Domaica, Norberto Walter Zwirner, Romina Elizabeth Araya, Jessica Mariel Sierra, Nicolás Torres, Florencia Secchiari
Publikováno v: The Journal of Immunology. 200:1008-1015
NK cells play important roles during immunosurveillance against tumors and viruses as they trigger cytotoxicity against susceptible cells and secrete pro-inflammatory cytokines such as IFN-g. In addition, upon activation, macrophages can become pro-i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::578f143d9a39514674663a7e95d58222
https://doi.org/10.4049/jimmunol.1700737
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