Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Florencia Sardi"'
Autor:
Diego Benítez, Jaime Franco, Florencia Sardi, Alejandro Leyva, Rosario Durán, Gahee Choi, Gyongseon Yang, Taehee Kim, Namyoul Kim, Jinyeong Heo, Kideok Kim, Honggun Lee, Inhee Choi, Constantin Radu, David Shum, Joo Hwan No, Marcelo A. Comini
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 912-929 (2022)
Trypanothione synthetase (TryS) catalyses the synthesis of N1,N8-bis(glutathionyl)spermidine (trypanothione), which is the main low molecular mass thiol supporting several redox functions in trypanosomatids. TryS attracts attention as molecular targe
Externí odkaz:
https://doaj.org/article/d6287e9bbb0746028794672207991f63
Autor:
Florencia Klein, Florencia Sardi, Matías R. Machado, Claudia Ortega, Marcelo A. Comini, Sergio Pantano
Publikováno v:
Frontiers in Molecular Biosciences, Vol 8 (2021)
The detection of small molecules in living cells using genetically encoded FRET sensors has revolutionized our understanding of signaling pathways at the sub-cellular level. However, engineering fluorescent proteins and specific binding domains to cr
Externí odkaz:
https://doaj.org/article/506ef62e721c4ac99ed388bf521b507a
Autor:
Jaime Franco, Florencia Sardi, László Szilágyi, Katalin E. Kövér, Krisztina Fehér, Marcelo A. Comini
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 3, Pp 303-313 (2017)
With the aim to develop compounds able to target multiple metabolic pathways and, thus, to lower the chances of drug resistance, we investigated the anti-trypanosomal activity and selectivity of a series of symmetric diglycosyl diselenides and disulf
Externí odkaz:
https://doaj.org/article/0114ed7a99324f6a988f2023ae3a535d
Autor:
Claudio Olea Azar, Marcelo A. Comini, Florencia Sardi, Gustavo Salinas, Michel Lapier, Eugenia Putzu, Esteban Rodríguez Arce, Lucía Otero, João Costa Pessoa, Gustavo A. Echeverría, Oscar E. Piro, Juan Diego Maya, Gastón Risi, Isabel Correia, Andrea Medeiros, Dinorah Gambino
Publikováno v:
CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
In the search for a more effective chemotherapy for the treatment of Chagas’ disease and human African trypanosomiasis, caused by Trypanosoma cruzi and Trypanosoma brucei parasites, respectively, the use of organometallic compounds may be a promisi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::096c6fc9e32c34925a25c1d09a604759
https://doi.org/10.1039/c9dt01317b
https://doi.org/10.1039/c9dt01317b
Autor:
Katalin E. Kövér, Krisztina Fehér, Marcelo A. Comini, László Szilágyi, Florencia Sardi, Jaime Franco
Publikováno v:
International Journal for Parasitology: Drugs and Drug Resistance
International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 3, Pp 303-313 (2017)
International Journal for Parasitology: Drugs and Drug Resistance, Vol 7, Iss 3, Pp 303-313 (2017)
With the aim to develop compounds able to target multiple metabolic pathways and, thus, to lower the chances of drug resistance, we investigated the anti-trypanosomal activity and selectivity of a series of symmetric diglycosyl diselenides and disulf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3a70f1046cd3e9d5768b88ff52d5f8c
https://doi.org/10.1016/j.ijpddr.2017.08.001
https://doi.org/10.1016/j.ijpddr.2017.08.001
Autor:
Claudia Vanesa Piattoni, Florencia Klein, Sergio Pantano, Florencia Sardi, Mariela Bollati-Fogolín, Marcelo A. Comini
Publikováno v:
Free radical biologymedicine. 134
Maintenance of intracellular redox homeostasis is critical for cell survival, proliferation, differentiation, and signaling. In this regard, major changes in the intracellular redox milieu may lead to cell death whereas subtle increases in the level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec68b37380f885525ddd1980d5f56309
https://pubmed.ncbi.nlm.nih.gov/30735840
https://pubmed.ncbi.nlm.nih.gov/30735840
Autor:
María Victoria Tourn, Bernard Knoops, Bruno Manta, André Clippe, Florencia Sardi, Stephanie Portillo-Ledesma, Gerardo Ferrer-Sueta, E. Laura Coitiño, Beatriz Alvarez
Publikováno v:
Biochemistry. 53:6113-6125
Human peroxiredoxin-5 (PRDX5) is a thiol peroxidase that reduces H2O2 10(5) times faster than free cysteine. To assess the influence of two conserved residues on the reactivity of the critical cysteine (C47), we determined the reaction rate constants
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0877412b2963de0b8199c3237739e05d
https://doi.org/10.1021/bi500389m
https://doi.org/10.1021/bi500389m
Autor:
Gerardo Ferrer-Sueta, Florencia Sardi, Stephanie Portillo-Ledesma, Bruno Manta, Marcelo A. Comini, Bernard Knoops
Publikováno v:
Analytical Biochemistry
Analytical Biochemistry, Elsevier Masson, 2013, 435 (1), pp.74-82. ⟨10.1016/j.ab.2012.12.017⟩
Analytical Biochemistry, Elsevier Masson, 2013, 435 (1), pp.74-82. ⟨10.1016/j.ab.2012.12.017⟩
International audience; A method based on the differential reactivity of thiol and thiolate with monobromobimane (mBBr) has been developed to measure nucleophilicity and acidity of protein and low-molecular-weight thiols. Nucleophilicity of the thiol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59adbac45d985849c59c0e39f934a119
https://hal-riip.archives-ouvertes.fr/pasteur-00847102/file/1-s2.0-S0003269712006458-main.pdf
https://hal-riip.archives-ouvertes.fr/pasteur-00847102/file/1-s2.0-S0003269712006458-main.pdf
