Zobrazeno 1 - 10 of 39 pro vyhledávání: '"Florencia Gottardo"'
1
Akademický článek
Development of an efficient NUPR1 inhibitor with anticancer activity
Autor: Xi Liu, Ana Jimenez-Alesanco, Zexian Li, Bruno Rizzuti, José L. Neira, Matías Estaras, Ling Peng, Eduardo Chuluyan, Juan Garona, Florencia Gottardo, Adrián Velazquez-Campoy, Yi Xia, Olga Abian, Patricia Santofimia-Castaño, Juan Iovanna
Publikováno v: Scientific Reports, Vol 14, Iss 1, Pp 1-20 (2024)
Abstract Pancreatic cancer is highly lethal and has limited treatment options available. Our team had previously developed ZZW-115, a promising drug candidate that targets the nuclear protein 1 (NUPR1), which is involved in pancreatic cancer developm
Externí odkaz: https://doaj.org/article/b3e694c92f77496eb7010faf3dfac971
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2
Akademický článek
Papel del péptido mitocondrial humanina como blanco terapéutico en cáncer y neurodegeneración
Autor: Antonela Sofía Asad, Camila Florencia Zuccato, Alejandro Javier Nicola Candia, María Florencia Gottardo, Mariela Alejandra Moreno Ayala, María Susana Theas, Adriana Seilicovich, Marianela Candolfi
Publikováno v: NOVA, Vol 17, Iss 32, Pp 9-24 (2019)
La humanina es un péptido derivado de la mitocondria con efectos protectores robustos contra una gran variedad de estímulos citotóxicos en diversos tipos celulares. Esto la convierte en un blanco terapéutico interesante para muchas enfermedades,
Externí odkaz: https://doaj.org/article/27e6c1b9c8c1435488e00d7fc208aaa6
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3
Exploring the Role of the Inhibitor of Apoptosis BIRC6 in Breast Cancer: A Database Analysis
Autor: Santiago M. Gómez Bergna, Abril Marchesini, Leslie C. Amorós Morales, Paula N. Arrías, Hernán G. Farina, Víctor Romanowski, M. Florencia Gottardo, Matias L. Pidre
Publikováno v: JCO Clinical Cancer Informatics.
PURPOSE The aim of the present work was to investigate the role of apoptosis inhibitor BIRC6 (baculoviral IAP repeat-containing protein 6) in breast cancer (BC), focusing particularly on its involvement in the metastatic cascade. METHODS We analyzed
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::427b552e6235324fea0af2039de283d6
https://doi.org/10.1200/cci.22.00093
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4
Mitochondrial humanin peptide acts as a cytoprotective factor in granulosa cell survival
Autor: Martin Irizarri, Víctor Romanowski, Gabriela Jaita, Mercedes Imsen, Daniel Martin, Francesca E. Duncan, Matías Luis Pidre, Julia G Conte, Adriana Seilicovich, Carolina Marvaldi, Sharrón L. Manuel, María Florencia Gottardo
Publikováno v: Reproduction. 161:581-591
Humanin (HN) is a short peptide involved in many biological processes such as apoptosis, cell survival, inflammatory response, and reaction to stressors like oxidative stress, between others. In the ovary, a correct balance between pro- and anti-apop
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::35b0c2ceb6e4508a9a0c80087f11d2bf
https://doi.org/10.1530/rep-20-0197
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6
Papel del péptido mitocondrial humanina como blanco terapéutico en cáncer y neurodegeneración
Autor: Alejandro Javier Nicola-Candia, Adriana Seilicovich, María Florencia Gottardo, Mariela Alejandra Moreno-Ayala, Camila Florencia Zuccato, Marianela Candolfi, Antonela Sofía Asad, María Susana Theas
Publikováno v: NOVA, Vol 17, Iss 32, Pp 9-24 (2019)
Nova, Volume: 17, Issue: 32, Pages: 24-9, Published: DEC 2019
Resumen La humanina es un péptido derivado de la mitocondria con efectos protectores robustos contra una gran variedad de estímulos citotóxicos en diversos tipos celulares. Esto la convierte en un blanco terapéutico interesante para muchas enferm
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9d96c3e592f1b31c623515a8bd30f16
https://doi.org/10.22490/24629448.3630
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7
Akademický článek
Antiapoptotic factor humanin is expressed in normal and tumoral pituitary cells and protects them from TNF-α-induced apoptosis.
Autor: María Florencia Gottardo, Gabriela Jaita, María Laura Magri, Sandra Zárate, Mariela Moreno Ayala, Jimena Ferraris, Guadalupe Eijo, Daniel Pisera, Marianela Candolfi, Adriana Seilicovich
Publikováno v: PLoS ONE, Vol 9, Iss 10, p e111548 (2014)
Humanin (HN) is a 24-amino acid peptide with cytoprotective action in several cell types such as neurons and testicular germ cells. Rattin (HNr), a homologous peptide of HN expressed in several adult rat tissues, also has antiapoptotic action. In the
Externí odkaz: https://doaj.org/article/ae3327bb11d1492ba592d9330660511a
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8
Exploring the metastatic role of the inhibitor of apoptosis BIRC6 in Breast Cancer
Autor: Santiago Manuel Gómez Bergna, Leslie C. Amorós Morales, Abril Marchesini, Matías Luis Pidre, María Florencia Gottardo, Paula Nazarena Arrías, Hernan G. Farina, Víctor Romanowski
Breast cancer is the most common cancer as well as the first cause of death by cancer in women worldwide. BIRC6 (baculoviral IAP repeat-containing protein 6) is a member of the inhibitors of apoptosis protein family thought to play an important role
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1e211781cd4de0c447dd48af75cb1e07
https://doi.org/10.1101/2021.04.08.438518
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9
Akademický článek
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10
Humanin promotes tumor progression in experimental triple negative breast cancer
Autor: Marina Teresita Isla Larrain, Mariela A. Moreno Ayala, Matías Luis Pidre, Mercedes Imsen, Alejandro Javier Nicola Candia, Adriana Seilicovich, Antonela Sofía Asad, María Florencia Gottardo, Marianela Candolfi, Víctor Romanowski, Camila Florencia Zuccato, Aldo Creton
Publikováno v: CONICET Digital (CONICET)
Consejo Nacional de Investigaciones Científicas y Técnicas
instacron:CONICET
Scientific Reports
SEDICI (UNLP)
Universidad Nacional de La Plata
instacron:UNLP
Scientific Reports, Vol 10, Iss 1, Pp 1-12 (2020)
Humanin (HN) is a mitochondrial-derived peptide with cytoprotective efect in many tissues. Administration of HN analogs has been proposed as therapeutic approach for degenerative diseases. Although HN has been shown to protect normal tissues from che
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b848c8091c7aa5faf04586caf8b6935
https://www.nature.com/articles/s41598-020-65381-7
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