Výsledky vyhledávání - "Florence Serres"

Akademický článek

Striatal Dopamine Transporter Function Is Facilitated by Converging Biology of α-Synuclein and Cholesterol

Autor: Sarah Threlfell, Amir Saeid Mohammadi, Brent J. Ryan, Natalie Connor-Robson, Nicola J. Platt, Rishi Anand, Florence Serres, Trevor Sharp, Nora Bengoa-Vergniory, Richard Wade-Martins, Andrew Ewing, Stephanie J. Cragg, Katherine R. Brimblecombe

Publikováno v: Frontiers in Cellular Neuroscience, Vol 15 (2021)

Striatal dopamine transporters (DAT) powerfully regulate dopamine signaling, and can contribute risk to degeneration in Parkinson’s disease (PD). DATs can interact with the neuronal protein α-synuclein, which is associated with the etiology and mo

Externí odkaz: https://doaj.org/article/d94e14e6aa624a13a530f30f01d4e044

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S32006, a novel 5-HT2C receptor antagonist displaying broad-based antidepressant and anxiolytic properties in rodent models

Autor: Amélie Soumier, Trevor Sharp, Mariusz Papp, Mauricette Brocco, Gunnar Flik, Jean-Michel Rivet, Anne Dekeyne, Françoise Lejeune, Thomas I. F. H. Cremers, Alain Gobert, Florence Serres, Millan Mark, Annie Daszuta, Olivier Muller, Clotilde Mannoury la Cour, Gilbert Lavielle

Publikováno v: Psychopharmacology (Berl)
Psychopharmacology (Berl), 2008, 199 (4), pp.549-68

RATIONALE: Serotonin (5-HT)(2C) receptors are implicated in the control of mood, and their blockade is of potential interest for the management of anxiodepressive states. OBJECTIVES: Herein, we characterized the in vitro and in vivo pharmacological p

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4b939857ddaecc03e4bac8547193eef2
https://ora.ox.ac.uk/objects/uuid:bf9f3d5a-5050-4674-be0f-6a9c9f69b4b2

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Blockade of α2-adrenoceptors induces Arc gene expression in rat brain in a glutamate receptor-dependent manner: A combined qPCR, in situ hybridisation and immunocytochemistry study

Autor: Brian P. Lockhart, Trevor Sharp, Jean-Pierre Galizzi, Marianne Rodriguez, Millan Mark, Florence Serres, Jean-Michel Rivet

Publikováno v: Neuropharmacology. 63:992-1001

Studies of 5-HT-glutamate interactions suggest that activation of brain 5-HT(2A) receptors leads to an AMPA receptor-mediated induction of the immediate early (activity-dependent) gene, Arc (Arg3.1). In this respect, noradrenaline-glutamate interacti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::efcaa19d96315f0fe43b20d9751c24ab
https://doi.org/10.1016/j.neuropharm.2012.06.068

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Molecular adaptation to chronic antidepressant treatment: evidence for a more rapid response to the novel α2-adrenoceptor antagonist/5-HT-noradrenaline reuptake inhibitor (SNRI), S35966, compared to the SNRI, venlafaxine

Autor: Millan Mark, Florence Serres, Trevor Sharp

Publikováno v: The International Journal of Neuropsychopharmacology. 15:617-629

Evidence of early changes in neural plasticity may aid the prediction of rapid-onset antidepressant drugs. Here we compared the dual α2-adrenoceptor antagonist/5-HT-noradrenaline reuptake inhibitor (SNRI), S35966, to the SNRI, venlafaxine, with rega

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0c345715908919e01826d85efe90fc7a
https://doi.org/10.1017/s1461145711000733

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Datos para un aumento en los receptores 5-HT2A funcionales de las plaquetas en pacientes deprimidos utilizando el nuevo ligando [l25I]-DOI

Autor: M. Valli, J.M. Azorin, Florence Serres, R. Jeanningros

Publikováno v: European psychiatry (Ed. Española). 7:294-303

ResumenSe han implicado anomalías en el sistema serotonérgico en la patofisiología de los trastornos depresivos. Las plaquetas humanas poseen receptores de serotonina-2A (5-HT2A), e investigaciones anteriores que han utilizado LSD o ketanserina co

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1c3b63408f51e970d3e7ea13962c77ad
https://doi.org/10.1017/s1134066500007931

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Evidence for an increase in functional platelet 5-HT2A receptors in depressed patients using the new ligand [125I]-DOI

Autor: J.M. Azorin, Florence Serres, Régine Jeanningros, M. Valli

Publikováno v: European Psychiatry. 14:451-457

SummaryAbnormalities in the serotonergic system have been implicated in the pathophysiology of depressive disorders. Human platelets possess serotonin-2A (5-HT2A) receptors, and previous research using LSD or ketanserin as ligands have indicated that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2e457e146040a40d9b78f1101f11a89
https://doi.org/10.1016/s0924-9338(99)00222-9

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Red blood cell l-tryptophan uptake in depression: Kinetic analysis in untreated depressed patients and healthy volunteers

Autor: Jean-Michel Azorin, D. Dassa, Sylvain Grignon, Florence Serres, Régine Jeanningros

Publikováno v: Psychiatry Research. 63:151-159

Kinetic parameters (Vmax and K(m)) of L-tryptophan (TRP) uptake into red blood cells (RBC) were measured in 72 drug-free depressed inpatients and 35 healthy volunteers. Mean Vmax and K(m) values were not significantly different between patients and v

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5a9465a953de41a7b66737e641a09b6e
https://doi.org/10.1016/0165-1781(96)02805-3

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S32212, a novel serotonin type 2C receptor inverse agonist/α2-adrenoceptor antagonist and potential antidepressant: II. A behavioral, neurochemical, and electrophysiological characterization

Autor: Kevin C. F. Fone, Berend Olivier, Florence Loiseau, Johnny S.W. Chan, Anne Dekeyne, Florence Serres, Trevor Sharp, Gilbert Lavielle, Mauricette Brocco, Gunnar Flik, Thomas I. F. H. Cremers, Jean-Michel Rivet, Alain P. Gobert, Millan Mark, Benjamin Di Cara, David J. G. Watson, Raymond Cespuglio, Mariusz Papp

Publikováno v: The Journal of pharmacology and experimental therapeutics. 340(3)

The present studies characterized the functional profile of N-[4-methoxy-3-(4-methylpiperazin-1-yl)phenyl]-1,2-dihydro-3-H-benzo[e]indole-3-carboxamide) (S32212), a combined serotonin (5-HT)(2C) receptor inverse agonist and α(2)-adrenoceptor antagon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ca7dc83e4ff57a582150629a57ac167
https://pubmed.ncbi.nlm.nih.gov/22178753

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Molecular adaptation to chronic antidepressant treatment: evidence for a more rapid response to the novel α₂-adrenoceptor antagonist/5-HT-noradrenaline reuptake inhibitor (SNRI), S35966, compared to the SNRI, venlafaxine

Autor: Florence, Serres, Mark J, Millan, Trevor, Sharp

Publikováno v: The international journal of neuropsychopharmacology. 15(5)

Evidence of early changes in neural plasticity may aid the prediction of rapid-onset antidepressant drugs. Here we compared the dual α₂-adrenoceptor antagonist/5-HT-noradrenaline reuptake inhibitor (SNRI), S35966, to the SNRI, venlafaxine, with re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c0c417fe75e2a961256c7f1a376d09ec
https://pubmed.ncbi.nlm.nih.gov/21733241

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Nicotine regulates SH-SY5Y neuroblastoma cell proliferation through the release of brain-derived neurotrophic factor

Autor: Florence Serres, Stephen L. Carney

Publikováno v: Brain research. 1101(1)

Nicotine has been shown to produce some beneficial effects in neurodegenerative disorders, and several studies have suggested that these effects may be mediated in part through the action of the neurotrophic factor BDNF. To further elucidate the inte

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99baa0e1ebe6e560a09d956f8164579e
https://pubmed.ncbi.nlm.nih.gov/16790237

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