Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Florence Moureau"'
Autor:
Martyn D. Wood, Anna Kolobova, Florence Moureau, Glen Ernst, Daniel Akuma, Ingrid P. Buchler, Florian Montel, James C. Barrow, Huijun Wei, Dominique Swinnen, Gregory V. Carr, Michael S. Poslusney, Emilie Jigorel, Vinh Au, Pablo De León, Michael DePasquale, Martha Kimos, Monika Sarah E.D. Schulze, Yifang Huang
Publikováno v:
Journal of Medicinal Chemistry. 61:9647-9665
A series of 8-hydroxy quinolines were identified as potent inhibitors of catechol O-methyltransferase (COMT) with selectivity for the membrane-bound form of the enzyme. Small substituents at the 7-position of the quinoline were found to increase meta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0548e3750c7972bb8419983749ba6e77
https://doi.org/10.1021/acs.jmedchem.8b01126
https://doi.org/10.1021/acs.jmedchem.8b01126
Autor:
Ingrid P. Buchler, Noelle White, Florian Montel, Florence Moureau, Gregory V. Carr, Thierry Demaude, Véronique Durieu, Daniel Akuma, James C. Barrow, Pablo De León, Martyn D. Wood, Nathalie Van houtvin, Vinh Au, Huijun Wei, Marie Christine Vandergeten, Emilie Jigorel, Yifang Huang, Dominique Swinnen, Anna Kolobova, Michael S. Poslusney, Martha Kimos, Glen Ernst, Michael DePasquale, Spencer Byers, Sabine Defays
Publikováno v:
ACS Medicinal Chemistry Letters
A series of bicyclic pyridones were identified as potent inhibitors of catechol O-methyltransferase (COMT). Substituted benzyl groups attached to the basic nitrogen of the core scaffold gave the most potent inhibitors within this series. Rat pharmaco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9cf6bbaad26b38d002dd4bc88ec3368
https://pubmed.ncbi.nlm.nih.gov/32038769
https://pubmed.ncbi.nlm.nih.gov/32038769
Autor:
Florence Moureau, Pascale Lacombe, C. Burrus, Colette Gable, Maria Do Rosario Pereira Simoes, M. Konzelmann, Jean Paysant, François Luthi
Publikováno v:
Hand Surgery and Rehabilitation. 35:490-491
Objectif Le « Bilan 400 points » (B400) est utilise depuis 20 ans et evalue la fonction de la main dans quatre dimensions : mobilite, force, prise monomanuelle et deplacement d’objets, fonction bimanuelle. Nous presentons les resultats preliminai
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::047f73099101371dd98a449063a28ac8
https://doi.org/10.1016/j.hansur.2016.10.209
https://doi.org/10.1016/j.hansur.2016.10.209
Autor:
Bernard Christophe, T. Taverne, Patrick Pasau, Jean-Pierre Hénichart, Christophe Genicot, Florence Moureau, Luc Quere, Laurence Goossens, B. J. Van Keulen, Michel Gillard, Marie-Agnes Lassoie, Philippe Collart, Thomas Ryckmans, F. Stiernet, Jean-Marie Nicolas, Michel Neuwels
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 13:437-442
Benzyloxyphenethylpiperazines are a new class of high affinity NK1 receptor antagonists. Oral bioavailability and selectivity can be fine tuned by the nature of the substituents on the basic nitrogen atom. Addition of substituents with a carboxylic a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06f934cf18d1ae07e1b0903847f27e43
https://doi.org/10.1016/s0960-894x(02)00956-3
https://doi.org/10.1016/s0960-894x(02)00956-3
Publikováno v:
Letters in Peptide Science. 5:155-158
Molecular recognition is a central problem in medicinal sciences, and therefore a knowledge of the salient molecular features neccessary for efficient interaction with a receptor as well as their relative spatial arrangement is of crucial importance.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::2a55e145b2baa06b668249b56a59f059
https://doi.org/10.1007/bf02443460
https://doi.org/10.1007/bf02443460
Autor:
Xavier Sauvage, Véronique Bollu, Yannick Quesnel, Philippe Michel, Anne Valade, Nathalie Price, Laurence Archen, Yves Evrard, Eric Jnoff, Laurent Provins, Benoit Kenda, Joël Mercier, Florence Moureau, Florian Montel, Bénédicte Lallemand, Stephane Carre
Publikováno v:
ChemMedChem. 9(4)
The role of the synaptic vesicle protein 2A (SV2A) protein, target of the antiepileptic drug levetiracetam, is still mostly unknown. Considering its potential to provide in vivo functional insights into the role of SV2A in epileptic patients, the dev
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c32df1e8e39b7322d18f7535f9a030ed
https://pubmed.ncbi.nlm.nih.gov/24446373
https://pubmed.ncbi.nlm.nih.gov/24446373
Autor:
Florence Moureau, Jean-Pierre Hénichart, Michel Neuwels, Raymond Houssin, Marie-Agnes Lassoie, Didier Berckmans, Edmond Differding, Solo Goldstein
Publikováno v:
Letters in Peptide Science. 2:125-134
Nine potent and selective substance P receptor antagonists (NK1 -) were analyzed with respect to their conformational space, with the aim to suggest probable conformations adopted at the receptor site and superposition rules for each structure (pharm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4fd3e7eed4649a73ee83e89a99d9dd35
https://doi.org/10.1007/bf00119138
https://doi.org/10.1007/bf00119138
Autor:
Florence Moureau, Henrik Klitgaard, Edmond Differding, Anne Frycia, Philippe Michel, Bruno Fuks, Patrick Pasau, Patrice Talaga, Michel Gillard, Benoit Kenda, Benedicte Lallemand, Alain Matagne
Publikováno v:
Journal of medicinal chemistry. 47(3)
(S)-alpha-ethyl-2-oxopyrrolidine acetamide 2 (levetiracetam, Keppra, UCB S.A.), a structural analogue of piracetam, has recently been approved as an add-on treatment of refractory partial onset seizures in adults. This drug appears to combine signifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e6194d9ed710c1a9d4a5d13423ebeb59
https://pubmed.ncbi.nlm.nih.gov/14736235
https://pubmed.ncbi.nlm.nih.gov/14736235