Zobrazeno 1 - 10
of 76
pro vyhledávání: '"Florence Margottin"'
Autor:
Virginie Vauthier, Angélique Lasserre, Marina Morel, Margaux Versapuech, Clarisse Berlioz-Torrent, Alessia Zamborlini, Florence Margottin-Goguet, Roy Matkovic
Publikováno v:
Retrovirology, Vol 19, Iss 1, Pp 1-12 (2022)
Abstract Background TASOR, a component of the HUSH repressor epigenetic complex, and SAMHD1, a cellular triphosphohydrolase (dNTPase), are both anti-HIV proteins antagonized by HIV-2/SIVsmm Viral protein X. As a result, the same viral protein is able
Externí odkaz:
https://doaj.org/article/a8088980491f4d10ac9850ed90ada31b
Autor:
Roy Matkovic, Marina Morel, Sophie Lanciano, Pauline Larrous, Benjamin Martin, Fabienne Bejjani, Virginie Vauthier, Maike M. K. Hansen, Stéphane Emiliani, Gael Cristofari, Sarah Gallois-Montbrun, Florence Margottin-Goguet
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
The human silencing hub (HUSH) complex, which includes TASOR, deposits repressive marks on HIV proviruses, resulting in gene repression. Here, Matkovic et al. show that TASOR interacts with RNA Polymerase II, predominantly under its elongating state,
Externí odkaz:
https://doaj.org/article/e660e7b792034553849b95125b645cbc
Autor:
Charlotte Martinat, Arthur Cormier, Joëlle Tobaly-Tapiero, Noé Palmic, Nicoletta Casartelli, Bijan Mahboubi, Si’Ana A. Coggins, Julian Buchrieser, Mirjana Persaud, Felipe Diaz-Griffero, Lucile Espert, Guillaume Bossis, Pascale Lesage, Olivier Schwartz, Baek Kim, Florence Margottin-Goguet, Ali Saïb, Alessia Zamborlini
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
SAMHD1 is a cellular dNTPase proposed to inhibit HIV-1 reverse transcription in non-cycling immune cells by limiting dNTP substrate supply; its anti-viral but not dNTPase function is downregulated by phosphorylation of T592. Here, Martinat et al. des
Externí odkaz:
https://doaj.org/article/70d02ba8c29446d69d93dada293f5c11
Autor:
Michaël M. Martin, Roy Matkovic, Pauline Larrous, Marina Morel, Angélique Lasserre, Virginie Vauthier, Florence Margottin-Goguet
Publikováno v:
PLoS Pathogens, Vol 17, Iss 10 (2021)
Human Immunodeficiency viruses type 1 and 2 (HIV-1 and HIV-2) succeed to evade host immune defenses by using their viral auxiliary proteins to antagonize host restriction factors. HIV-2/SIVsmm Vpx is known for degrading SAMHD1, a factor impeding the
Externí odkaz:
https://doaj.org/article/05385fe8f4224a13931c53c96d9a993f
Autor:
Arthur Roux, Héloise Leroy, Bénédicte De Muylder, Lucie Bracq, Samia Oussous, Isabelle Dusanter-Fourt, Ghina Chougui, Rachida Tacine, Clotilde Randriamampita, Delphine Desjardins, Roger Le Grand, Frederic Bouillaud, Serge Benichou, Florence Margottin-Goguet, Remi Cheynier, Georges Bismuth, Marianne Mangeney
Publikováno v:
PLoS Pathogens, Vol 15, Iss 5, p e1007669 (2019)
HIV-1 is dependent on the host cell for providing the metabolic resources for completion of its viral replication cycle. Thus, HIV-1 replicates efficiently only in activated CD4+ T cells. Barriers preventing HIV-1 replication in resting CD4+ T cells
Externí odkaz:
https://doaj.org/article/c634db830e23453e9235123af64537cd
Publikováno v:
Frontiers in Microbiology, Vol 10 (2019)
A prominent obstacle to HIV eradication in seropositive individuals is the viral persistence in latent reservoir cells, which constitute an HIV sanctuary out of reach of highly active antiretroviral therapies. Thus, the study of molecular mechanisms
Externí odkaz:
https://doaj.org/article/7ea1223e108f4ecfb90b665980daf722
Autor:
Sylvie Rodrigues-Ferreira, Erwann le Rouzic, Traci Pawlowski, Anand Srivastava, Florence Margottin-Goguet, Clara Nahmias
Publikováno v:
International Journal of Hypertension, Vol 2013 (2013)
A complete renin-angiotensin system (RAS) is locally expressed in the brain and fulfills important functions. Angiotensin II, the major biologically active peptide of the RAS, acts via binding to two main receptor subtypes designated AT1 and AT2. The
Externí odkaz:
https://doaj.org/article/aafb699a08b44e30b4b8a4d0de9e108f
Autor:
Claire Maudet, Adèle Sourisce, Loïc Dragin, Hichem Lahouassa, Jean-Christophe Rain, Serge Bouaziz, Bertha Cécilia Ramirez, Florence Margottin-Goguet
Publikováno v:
PLoS ONE, Vol 8, Iss 10, p e77320 (2013)
The Vpr protein from type 1 and type 2 Human Immunodeficiency Viruses (HIV-1 and HIV-2) is thought to inactivate several host proteins through the hijacking of the DCAF1 adaptor of the Cul4A ubiquitin ligase. Here, we identified two transcriptional r
Externí odkaz:
https://doaj.org/article/a1bf6b764bdc48eaaa80f76809438c1e
Autor:
Richard S Mitchell, Chris Katsura, Mark A Skasko, Katie Fitzpatrick, David Lau, Autumn Ruiz, Edward B Stephens, Florence Margottin-Goguet, Richard Benarous, John C Guatelli
Publikováno v:
PLoS Pathogens, Vol 5, Iss 5, p e1000450 (2009)
The interferon-induced transmembrane protein BST-2/CD317 (tetherin) restricts the release of diverse enveloped viruses from infected cells. The HIV-1 accessory protein Vpu antagonizes this restriction by an unknown mechanism that likely involves the
Externí odkaz:
https://doaj.org/article/9f2e60a5427f440ca85621752c99e315
Autor:
Laetitia Carthagena, Anna Bergamaschi, Joseph M Luna, Annie David, Pradeep D Uchil, Florence Margottin-Goguet, Walther Mothes, Uriel Hazan, Catherine Transy, Gianfranco Pancino, Sébastien Nisole
Publikováno v:
PLoS ONE, Vol 4, Iss 3, p e4894 (2009)
BackgroundTripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role
Externí odkaz:
https://doaj.org/article/b41400da254040758c1fd396562a3da0