Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Florence M. Ndikum-Moffor"'
Publikováno v:
MOJ Toxicology. 3
An unidentified peak in a drug substance or drug product chromatogram raises many questions. What is the impurity? What is the source of the impurity? How much impurity is there? Can the impurity level be reduced or eliminated? Is the impurity toxic?
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efe2291bfa77bd2c2a24873231e7d3d1
https://doi.org/10.15406/mojt.2017.03.00043
https://doi.org/10.15406/mojt.2017.03.00043
Autor:
Stephen M. Roberts, John W. Munson, Nigel G. J. Richards, Nagraj K. Bokinkere, Jennifer L. Brown, Florence M. Ndikum-Moffor
Publikováno v:
Chemical Research in Toxicology. 11:185-192
Cocaine is capable of producing hepatic necrosis in laboratory animals and humans. Studies in mice indicate that N-oxidative metabolism of cocaine is required for hepatotoxicity and have suggested that toxicity may result from the adduction of protei
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fd74b471cbce52cd6861f602d5aac24
https://doi.org/10.1021/tx970147c
https://doi.org/10.1021/tx970147c
Publikováno v:
Biochemical pharmacology. 66(1)
Cocaine has been shown to be hepatotoxic in mice, rats and humans. N-Oxidative metabolism of cocaine is required for this effect, and it has been proposed that binding of cocaine reactive metabolites formed via this pathway might be responsible for c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc25b39ba835978dc46abe1a481de974
https://pubmed.ncbi.nlm.nih.gov/12818370
https://pubmed.ncbi.nlm.nih.gov/12818370
Publikováno v:
Biochemical pharmacology. 60(5)
Cocaine is capable of producing severe hepatocellular necrosis in laboratory animals and humans. The mechanism of cocaine hepatotoxicity is not well understood, but appears to result from the actions of one or more N-oxidative metabolites of cocaine.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ba56387b4f2f67043188d03ecddbe01
https://pubmed.ncbi.nlm.nih.gov/10927019
https://pubmed.ncbi.nlm.nih.gov/10927019