Zobrazeno 1 - 10 of 199 pro vyhledávání: '"Florence M. Hofman"'
1
Akademický článek
Therapeutic Immunization against Glioblastoma
Autor: Virgil E. J. C. Schijns, Chrystel Pretto, Anna M. Strik, Rianne Gloudemans-Rijkers, Laurent Devillers, Denis Pierre, Jinah Chung, Manisha Dandekar, Jose A. Carrillo, Xiao-Tang Kong, Beverly D. Fu, Frank P. K. Hsu, Florence M. Hofman, Thomas C. Chen, Raphael Zidovetzki, Daniela A. Bota, Apostolos Stathopoulos
Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 9, p 2540 (2018)
Glioblastoma is the most common form of brain cancer in adults that produces severe damage to the brain leading to a very poor survival prognosis. The standard of care for glioblastoma is usually surgery, as well as radiotherapy followed by systemic
Externí odkaz: https://doaj.org/article/eba2520a09de4ae4841f22271d2c75e6
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2
Akademický článek
Induction of Pro-Apoptotic Endoplasmic Reticulum Stress in Multiple Myeloma Cells by NEO214, Perillyl Alcohol Conjugated to Rolipram
Autor: Thomas C. Chen, Nymph Chan, Shirin Labib, Jiali Yu, Hee-Yeon Cho, Florence M. Hofman, Axel H. Schönthal
Publikováno v: International Journal of Molecular Sciences, Vol 19, Iss 1, p 277 (2018)
Despite the introduction of new therapies for multiple myeloma (MM), many patients are still dying from this disease and novel treatments are urgently needed. We have designed a novel hybrid molecule, called NEO214, that was generated by covalent con
Externí odkaz: https://doaj.org/article/8d56f9ad78e24b72a1a1309037d3abc2
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3
Akademický článek
Developing a clinically relevant radiosensitizer for temozolomide-resistant gliomas.
Autor: Radu O Minea, Tuan Cao Duc, Stephen D Swenson, Hee-Yeon Cho, Mickey Huang, Hannah Hartman, Florence M Hofman, Axel H Schönthal, Thomas C Chen
Publikováno v: PLoS ONE, Vol 15, Iss 9, p e0238238 (2020)
The prognosis for patients with glioblastoma (GB) remains grim. Concurrent temozolomide (TMZ) radiation-the cornerstone of glioma control-extends the overall median survival of GB patients by only a few months over radiotherapy alone. While these sur
Externí odkaz: https://doaj.org/article/06b1342876a949aa97d7626567027847
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6
Supplementary Figures 1-4 from NEO212 Inhibits Migration and Invasion of Glioma Stem Cells
Autor: Florence M. Hofman, Thomas C. Chen, Axel H. Schönthal, Weijun Wang, Stephen D. Swenson, Hee-Yeon Cho, Thu Zan Thein, Nagore I. Marín-Ramos
Supplementary Figure 1. NEO212 is a conjugate of POH and TMZ; Supplementary Figure 2. NEO212 impairs GSC migration without affecting cell viability; Supplementary Figure 3. NEO212 impairs the invasion of several primary cultures of GBM cells and GSCs
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::27b2dc77f8e37100078cf20220603ea2
https://doi.org/10.1158/1535-7163.22505070
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7
Data from The Rolipram–Perillyl Alcohol Conjugate (NEO214) Is A Mediator of Cell Death through the Death Receptor Pathway
Autor: Thomas C. Chen, Florence M. Hofman, Axel H. Schönthal, Nagore I. Marín-Ramos, Mengting Ou, Rochelle A. Fayngor, Stephen D. Swenson, Weijun Wang, Thu Zan Thein, Hee-Yeon Cho
Glioblastoma (GBM) is a highly aggressive primary brain tumor with a poor prognosis. Treatment with temozolomide, standard of care for gliomas, usually results in drug resistance and tumor recurrence. Therefore, there is a great need for drugs that t
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5210bf57341432b354501c58572df7f4
https://doi.org/10.1158/1535-7163.c.6539610
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