Výsledky vyhledávání - "Florence Loi"

Akademický článek

Establishment of Green Fluorescent Protein and Firefly Luciferase Expressing Mouse Primary Macrophages for In Vivo Bioluminescence Imaging.

Autor: Jukka Pajarinen, Tzu-Hua Lin, Taishi Sato, Florence Loi, Zhenyu Yao, Yrjö T Konttinen, Stuart B Goodman

Publikováno v: PLoS ONE, Vol 10, Iss 11, p e0142736 (2015)

Macrophages play a key role in tissue homeostasis as well as in a range of pathological conditions including atherosclerosis, cancer, and autoimmunity. Many aspects of their in vivo behavior are, however, poorly understood. Bioluminescence imaging (B

Externí odkaz: https://doaj.org/article/ea7252daa06f4e61aee8b04b1383ed17

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Orthopaedic wear particle-induced bone loss and exogenous macrophage infiltration is mitigated by local infusion of NF-κB decoy oligodeoxynucleotide

Autor: Akira Nabeshima, Laura Lu, Zhenyu Yao, Luis A. Córdova, Stuart B. Goodman, Karthik Nathan, Eemeli Jämsen, Florence Loi, Tzuhua Lin, Emmanuel Gibon, Jukka Pajarinen

Publikováno v: Journal of Biomedical Materials Research Part A. 105:3169-3175

Excessive production of wear particles from total joint replacements induces chronic inflammation, macrophage infiltration, and consequent bone loss (periprosthetic osteolysis). This inflammation and bone remodeling are critically regulated by the tr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b99c024bc7517a01e30683506b0e09a
https://doi.org/10.1002/jbm.a.36169

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CCL2, CCL5, and IGF-1 participate in the immunomodulation of osteogenesis during M1/M2 transition in vitro

Autor: Luis A. Córdova, Akira Nabeshima, Stuart B. Goodman, Laura Lu, Florence Loi, Jukka Pajarinen, Zhenyu Yao, Tzuhua Lin, Emmanuel Gibon

Publikováno v: Journal of Biomedical Materials Research Part A. 105:3069-3076

The modulation of macrophage phenotype from pro-inflammatory (M1) to tissue healing (M2) via exogenous addition of interleukin-4 (IL-4) facilitates osteogenesis; however, the molecular mediators underlying this phenomenon remain unknown. This study c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f66650a0c1226918cccbc79de39ac2ae
https://doi.org/10.1002/jbm.a.36166

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Pro-inflammatory M1 macrophages promote Osteogenesis by mesenchymal stem cells via the COX-2-prostaglandin E2 pathway

Autor: Akira Nabeshima, Jukka Pajarinen, Emmanuel Gibon, Laura Lu, Tzuhua Lin, Karthik Nathan, Zhenyu Yao, Eemeli Jämsen, Florence Loi, Luis A. Córdova, Stuart B. Goodman

Publikováno v: Journal of Orthopaedic Research. 35:2378-2385

Bone fractures are among the most common orthopaedic problems that affect individuals of all ages. Immediately after injury, activated macrophages dynamically contribute to and regulate an acute inflammatory response that involves other cells at the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e0e3b64c89680600cac2b58befdeee41
https://doi.org/10.1002/jor.23553

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Mutant CCL2 protein coating mitigates wear particle-induced bone loss in a murine continuous polyethylene infusion model

Autor: Kensuke Egashira, Emmanuel Gibon, Eemeli Jämsen, Zhenyu Yao, Tzuhua Lin, Akira Nabeshima, Laura Lu, Xinyi Jiang, Jukka Pajarinen, Florence Loi, Luis A. Córdova, Stuart B. Goodman, Fan Yang

Publikováno v: Biomaterials. 117:1-9

Wear particle-induced osteolysis limits the long-term survivorship of total joint replacement (TJR). Monocyte/macrophages are the key cells of this adverse reaction. Monocyte Chemoattractant Protein-1 (MCP-1/CCL2) is the most important chemokine regu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05c1ad71c64a4622af9cac884e9ba705
https://doi.org/10.1016/j.biomaterials.2016.11.039

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Akademický článek

Evaluation of model‐based bioequivalence approach for single sample pharmacokinetic studies

Autor: Coralie Tardivon, Florence Loingeville, Mark Donnelly, Kairui Feng, Wanjie Sun, Guoying Sun, Stella Grosser, Liang Zhao, Lanyan Fang, France Mentré, Julie Bertrand

Publikováno v: CPT: Pharmacometrics & Systems Pharmacology, Vol 12, Iss 7, Pp 904-915 (2023)

Abstract In a traditional pharmacokinetic (PK) bioequivalence (BE) study, a two‐way crossover study is conducted, PK parameters (namely the area under the time‐concentration curve [AUC] and the maximal concentration [Cmax]) are obtained by noncom

Externí odkaz: https://doaj.org/article/139a16dd116f45258f338771f7006e43

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Plný text ve formátu HTML

NF-κB decoy oligodeoxynucleotide mitigates wear particle-associated bone loss in the murine continuous infusion model

Autor: Florence Loi, Taishi Sato, Changchun Fan, Zhenyu Yao, Luis A. Córdova, Stuart B. Goodman, Akira Nabeshima, Jukka Pajarinen, Tzuhua Lin, R. Y. Zhang, Emmanuel Gibon

Publikováno v: Acta Biomaterialia. 41:273-281

Total joint replacement is a cost-effective surgical procedure for patients with end-stage arthritis. Wear particle-induced chronic inflammation is associated with the development of periprosthetic osteolysis. Modulation of NF-κB signaling in macrop

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::885ac80de8ffc3e97024317c3e90dfeb
https://doi.org/10.1016/j.actbio.2016.05.038

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Aging Affects Bone Marrow Macrophage Polarization: Relevance to Bone Healing

Autor: Tzuhua Lin, Florence Loi, Emmanuel Gibon, Luis A. Córdova, Stuart B. Goodman, Jukka Pajarinen, Zhenyu Yao, Akira Nabeshima, Laura Lu

Publikováno v: Regenerative Engineering and Translational Medicine. 2:98-104

Macrophages are an important component of the inflammatory cascade by initiating and modulating the processes leading to tissue regeneration and bone healing. Depending on the local environment, macrophages can be polarized into M1 (pro-inflammatory)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8432670bf24a7a0ca7e2997bf2d331a5
https://doi.org/10.1007/s40883-016-0016-5

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