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pro vyhledávání: '"Florence Lichou"'
Autor:
Florence Lichou, Gosia Trynka
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-4 (2020)
Rapidly advancing genomic technologies and cross-disciplinary partnerships are accelerating the biological and clinical interpretation of genome-wide association studies, with some therapies developed based on these findings already being tested in c
Externí odkaz:
https://doaj.org/article/72fc06b5c3e34355876e42c054e4b445
Autor:
Matthieu Lewis, Valérie Prouzet‐Mauléon, Florence Lichou, Elodie Richard, Richard Iggo, Béatrice Turcq, François‐Xavier Mahon
Publikováno v:
Cancer Medicine, Vol 9, Iss 18, Pp 6739-6751 (2020)
Abstract Understanding resistance mechanisms in cancer is of utmost importance for the discovery of novel “druggable” targets. Efficient genetic screening, now even more possible with CRISPR‐Cas9 gene‐editing technology, next‐generation seq
Externí odkaz:
https://doaj.org/article/ee2e1b61d9ac4c1882f8c1d944da62fe
Autor:
Florence Lichou, Sébastien Orazio, Stéphanie Dulucq, Gabriel Etienne, Michel Longy, Christophe Hubert, Alexis Groppi, Alain Monnereau, François-Xavier Mahon, Béatrice Turcq
Publikováno v:
Human Genomics, Vol 13, Iss 1, Pp 1-11 (2019)
Abstract Background Targeted therapies have greatly improved cancer patient prognosis. For instance, chronic myeloid leukemia is now well treated with imatinib, a tyrosine kinase inhibitor. Around 80% of the patients reach complete remission. However
Externí odkaz:
https://doaj.org/article/afaf3dfcb3be4dcbb71a9c322a47951a
Autor:
Francois-Xavier Mahon, Matthieu Lewis, Béatrice Turcq, Elodie Richard, Florence Lichou, Valérie Prouzet-Mauléon, Richard Iggo
Publikováno v:
Cancer Medicine
Cancer Medicine, Vol 9, Iss 18, Pp 6739-6751 (2020)
Cancer Medicine, Vol 9, Iss 18, Pp 6739-6751 (2020)
Understanding resistance mechanisms in cancer is of utmost importance for the discovery of novel “druggable” targets. Efficient genetic screening, now even more possible with CRISPR‐Cas9 gene‐editing technology, next‐generation sequencing a
Autor:
Gosia Trynka, Florence Lichou
Publikováno v:
Nature Communications
Nature Communications, Vol 11, Iss 1, Pp 1-4 (2020)
Nature Communications, Vol 11, Iss 1, Pp 1-4 (2020)
Rapidly advancing genomic technologies and cross-disciplinary partnerships are accelerating the biological and clinical interpretation of genome-wide association studies, with some therapies developed based on these findings already being tested in c
Autor:
Florence Lichou
Publikováno v:
Florence Lichou
Génétique. Université de Bordeaux, 2019. Français. ⟨NNT : 2019BORD0066⟩
Génétique. Université de Bordeaux, 2019. Français. ⟨NNT : 2019BORD0066⟩
Chronic myeloid leukemia (CML) is a rare myeloproliferative syndrome treated by tyrosine kinase inhibitors, such as imatinib. Despite its efficacy, resistance to treatment is a persistent clinical issue. Notably, genetic variants causing alterations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=dedup_wf_001::d56d9493404aa1c5377014ca1f037ff8
http://www.theses.fr/2019BORD0066/document
http://www.theses.fr/2019BORD0066/document