Zobrazeno 1 - 10
of 91
pro vyhledávání: '"Florence L. Marlow"'
Autor:
Miranda L. Wilson, Shannon N. Romano, Nitya Khatri, Devora Aharon, Yulong Liu, Odelya H. Kaufman, Bruce W. Draper, Florence L. Marlow
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-17 (2024)
Abstract Reproductive success relies on proper establishment and maintenance of biological sex. In many animals, including mammals, the primary gonad is initially ovary biased. We previously showed the RNA binding protein (RNAbp), Rbpms2, is required
Externí odkaz:
https://doaj.org/article/3ae1f6e7f3fb4706a7fdf24731f672c3
Autor:
Florence L. Marlow
Publikováno v:
Stem Cell Research, Vol 21, Iss C, Pp 178-186 (2017)
Mitochondrial replacement therapy, a procedure to generate embryos with the nuclear genome of a donor mother and the healthy mitochondria of a recipient egg, has recently emerged as a promising strategy to prevent transmission of devastating mitochon
Externí odkaz:
https://doaj.org/article/4b5e6dad174643dc8abf01b76a14695c
Autor:
Florence L. Marlow
Publikováno v:
F1000Research, Vol 7 (2018)
Maternal control of development begins with production of the oocyte during oogenesis. All of the factors necessary to complete oocyte maturation, meiosis, fertilization, and early development are produced in the transcriptionally active early oocyte
Externí odkaz:
https://doaj.org/article/dbf60c58c83e4ae19b8e883c902879d8
Publikováno v:
Cell Reports, Vol 12, Iss 1, Pp 49-57 (2015)
Primordial germ cells (PGCs) are the stem cells of the germline. Generally, germline induction occurs via zygotic factors or the inheritance of maternal determinants called germ plasm (GP). GP is packaged into ribonucleoprotein complexes within oocyt
Externí odkaz:
https://doaj.org/article/add5c6b89b844106bbb7cf9e0efb60bf
Publikováno v:
Disease Models & Mechanisms, Vol 6, Iss 5, Pp 1246-1259 (2013)
SUMMARY Mutations in the human NOTCH3 gene cause CADASIL syndrome (cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy). CADASIL is an inherited small vessel disease characterized by diverse clinical manifestati
Externí odkaz:
https://doaj.org/article/7f00c94529ad4fc78839fa80e410140b
Publikováno v:
Cell Reports, Vol 15, Iss 4, p 909 (2016)
Externí odkaz:
https://doaj.org/article/3921f02c619447babaa9c20fe1edf037
Autor:
Elliott W Abrams, Ricardo Fuentes, Florence L Marlow, Manami Kobayashi, Hong Zhang, Sumei Lu, Lee Kapp, Shai R Joseph, Amy Kugath, Tripti Gupta, Virginia Lemon, Greg Runke, Amanda A Amodeo, Nadine L Vastenhouw, Mary C Mullins
Publikováno v:
PLoS Genetics, Vol 16, Iss 4, p e1008652 (2020)
Forward genetic screens remain at the forefront of biology as an unbiased approach for discovering and elucidating gene function at the organismal and molecular level. Past mutagenesis screens targeting maternal-effect genes identified a broad spectr
Externí odkaz:
https://doaj.org/article/5a7079db9b6942258bc6e78880fb3d19
In humans, premature ovarian insufficiency (POI) is caused by autoimmunity and genetic factors, such as mutation of BMP15, a key ovarian determining gene. The cellular mechanisms associated with ovarian failure caused by BMP15 mutation and immune con
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c14bdd0794d2683ca9b288a03d259cf5
https://doi.org/10.1101/2023.01.03.522645
https://doi.org/10.1101/2023.01.03.522645
Autor:
Sylvain, Bertho, Mara, Clapp, Torsten U, Banisch, Jan, Bandemer, Erez, Raz, Florence L, Marlow
Publikováno v:
Development
Fertility and gamete reserves are maintained by asymmetric divisions of the germline stem cells to produce new stem cells or daughters that differentiate as gametes. Before entering meiosis, differentiating germ cells (GCs) of sexual animals typicall
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::15cc90f3e23a3f31fd093b15a07f6150
https://doi.org/10.1242/dev.200629
https://doi.org/10.1242/dev.200629
Autor:
Devora Aharon, Florence L. Marlow
Publikováno v:
Cellular and Molecular Life Sciences. 79
Zebrafish have emerged as a major model organism to study vertebrate reproduction due to their high fecundity and external development of eggs and embryos. The mechanisms through which zebrafish determine their sex have come under extensive investiga
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2ee75b7f474acbff8ad3c59b77f58ac7
https://doi.org/10.1007/s00018-021-04066-4
https://doi.org/10.1007/s00018-021-04066-4