Whole exome sequencing for determination of tumor mutation load in liquid biopsy from advanced cancer patients.

Autor: Florence Koeppel, Steven Blanchard, Cécile Jovelet, Bérengère Genin, Charles Marcaillou, Emmanuel Martin, Etienne Rouleau, Eric Solary, Jean-Charles Soria, Fabrice André, Ludovic Lacroix

Publikováno v: PLoS ONE, Vol 12, Iss 11, p e0188174 (2017)

Tumor mutation load (TML) has been proposed as a biomarker of patient response to immunotherapy in several studies. TML is usually determined by tumor biopsy DNA (tDNA) whole exome sequencing (WES), therefore TML evaluation is limited by informative

Externí odkaz: https://doaj.org/article/e2b6f738d86a4647abfc46697be49b5a

OSIRIS: A Minimum Data Set for Data Sharing and Interoperability in Oncology

Autor: Vincent Le Texier, Laetitia Chanas, Pierre Saintigny, Sophie Gourgou, Vianney Jouhet, Marina Rousseau-Tsangaris, Manuel Tejeda, Bastien Rance, Julien Guerin, Anne-Laure Martin, Yec'han Laizet, Maud Toulmonde, Elisabeth Hess, François Lion, Florence Koeppel, Stéphanie Cox

Publikováno v: JCO Clinical Cancer Informatics
JCO Clinical Cancer Informatics, ASCO, 2021, 5, pp.256-265. ⟨10.1200/CCI.20.00094⟩
JCO Clinical Cancer Informatics, 2021, 5, pp.256-265. ⟨10.1200/CCI.20.00094⟩

PURPOSE Many institutions throughout the world have launched precision medicine initiatives in oncology, and a large amount of clinical and genomic data is being produced. Although there have been attempts at data sharing with the community, initiati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fccc2b656d9293e8d684e527628b529f
https://pubmed.ncbi.nlm.nih.gov/33720747

Added Value of Whole-Exome and Transcriptome Sequencing for Clinical Molecular Screenings of Advanced Cancer Patients With Solid Tumors

Autor: Marc Deloger, Marion Pedrero, Fabrice Andre, Yannick Boursin, Jean-Yves Scoazec, Jean-Charles Soria, Stefan Michiels, Alexandre Bobard, Etienne Rouleau, Florence Koeppel, Catherine Richon, Eric Solary, Ludovic Lacroix, Romy chen-Min-Tao, Guillaume Robert, Guillaume Meurice, Celine Lefebvre, Christophe Massard

Publikováno v: The Cancer Journal. 24:153-162

Comprehensive genomic profiling using high-throughput sequencing brings a wealth of information, and its place in the clinical setting has been increasingly prominent. This review emphasizes the utility of whole-exome sequencing (WES) and transcripto

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4050d540978290d7bbe425c51c0dd6d9
https://doi.org/10.1097/ppo.0000000000000322

Quickly finding a needle in a haystack: A new automated cardiac arrhythmia detection software for preclinical studies

Autor: David Labarre, Philippe Zitoun, Florence Koeppel

Publikováno v: Journal of Pharmacological and Toxicological Methods. 66:92-97

Introduction The occurrence of drug-induced arrhythmias in safety pharmacology or toxicology studies is a primary safety concern. The risk assessment requires an accurate knowledge of background arrhythmia incidence and frequency in the test system/s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf0b9bb5d4a17e7d6781b8a6cfd35d3
https://doi.org/10.1016/j.vascn.2012.04.008

Characterizations of irofulven cytotoxicity in combination with cisplatin and oxaliplatin in human colon, breast, and ovarian cancer cells

Autor: Florence Koeppel, Esteban Cvitkovic, Eric Raymond, Maria Serova, Annette K. Larsen, Stephen J. Waters, Fabien Calvo, Emily S. Van Laar, François Lokiec, V. Poindessous

Publikováno v: Cancer Chemotherapy and Pharmacology. 57:491-499

Purpose: This study assessed the cytotoxic effects of irofulven in combination with oxaliplatin and cisplatin in a panel of human cancer cell lines. Methods: Growth inhibition studies were performed using the human HT29 colon cancer cell line, iroful

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::850071870c8b138aacf07599a40b1e0f
https://doi.org/10.1007/s00280-005-0063-y