Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Florence Jovic"'
Autor:
Norman Lewis, Steve O. Moore, Michael Urquhart, Bernie M. Choudary, Florence Jovic, Giles Robert Gordon
Publikováno v:
Organic Process Research & Development. 16:1927-1939
A synthesis of the pleuromutilin antibiotic SB-268091 is described which includes a new and improved route to the quinuclidine-4-thiol ligand. This chemistry has been run on multikilo scale and involved a reductive double debenzylation using sodium i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a32221effaf952e339ce1fc9a30b923c
https://doi.org/10.1021/op300263w
https://doi.org/10.1021/op300263w
Autor:
Florence Jovic, Wilna J. Moree, Timothy D. Gross, Onorato Campopiano, Peng Wang, Shubham Chopade, Jayachandra P. Reddy, Raymond S. Gross, Scott E. Zook, Michael Ouellette, Shine Chou, Daniel Bonneville
Publikováno v:
Organic Process Research & Development. 12:929-939
The discovery route and subsequent scale-up routes for NBI-75043 are presented. When traditional batch chemistry was found to limit the scale of a key reaction, a flow reactor was designed and optimized to provide an alternate method of production.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bdebefe20bd66a2eae56ad734024cd3f
https://doi.org/10.1021/op800071m
https://doi.org/10.1021/op800071m
Autor:
Kasey Phan, Beth A. Fleck, Junko Tamiya, Chen Chen, Brian Dyck, Alan C. Foster, Florence Jovic, Mingzhu Zhang, Jonathan Grey, Troy Vickers, Joe A. Tran, Anna Aparicio
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3328-3332
A series of milnacipran analogs were synthesized and studied as monoamine transporter inhibitors, and several potent compounds with moderate lipophilicity were identified from the 1 S ,2 R -isomers. Thus, 15l exhibited IC 50 values of 1.7 nM at NET a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9cea1cee34c18284445a0ce4d1060174
https://doi.org/10.1016/j.bmcl.2008.04.025
https://doi.org/10.1016/j.bmcl.2008.04.025
Autor:
Anna Aparicio, Jonathan Grey, Florence Jovic, Liping Jin, Brian Dyck, Chen Chen, Mingzhu Zhang, Troy Vickers, Alan C. Foster, Hui Tang, Beth A. Fleck, Michael Johns, Junko Tamiya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 18:3230-3235
A series of milnacipran analogs containing a heteroaromatic group were synthesized and studied as monoamine transporter inhibitors. Many compounds exhibited higher potency than milnacipran at NET and NET/SERT with no significant change in lipophilici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70b2ba3348e8c4358309d32e937f0afa
https://doi.org/10.1016/j.bmcl.2008.04.045
https://doi.org/10.1016/j.bmcl.2008.04.045
Publikováno v:
Tetrahedron Letters. 46:6809-6814
In this letter, we describe the design and the synthesis of an organophosphorus hapten aimed at a mixed biotechnological–chemical strategy for the mild decontamination of exceedingly toxic nerve agent VX. Hapten will be used to raise and select mon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bdddcfdc329cca139e5e39e7c90ac1d
https://doi.org/10.1016/j.tetlet.2005.08.032
https://doi.org/10.1016/j.tetlet.2005.08.032
Autor:
Pierre-Yves Renard, Charles Mioskowski, Christophe Créminon, Frédéric Taran, Florence Jovic, Jacques Grassi, Sonia Dias
Publikováno v:
Journal of Immunological Methods. 269:81-98
We describe a new strategy for the preparation of catalytic antibodies based on a two-step procedure. Firstly, monoclonal antibodies are selected only if displaying the following binding features: binding both the substrate and a reactive group in su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fca66ca40e766946edc89b798aba10f
https://doi.org/10.1016/s0022-1759(02)00226-0
https://doi.org/10.1016/s0022-1759(02)00226-0
Autor:
Coon Timothy Richard, Raymond S. Gross, Siobhan Malany, Florence Jovic, Wilna J. Moree, Zhihong O’Brien, Sam R. J. Hoare, Paul D. Crowe, Fabio C. Tucci, Bin-Feng Li, Graham Beaton, Margaret J. Bradbury, Hua Wang, Jianyun Wen, Robert E. Petroski, Jinghua Yu, Aida Sacaan, Dragan Marinkovic, Lisa M. Hernández, Ajay Madan
Publikováno v:
Bioorganicmedicinal chemistry letters. 20(7)
SAR of lead benzothiophene H1-antihistamine 2 was explored to identify backup candidates with suitable pharmacokinetic profiles for an insomnia program. Several potent and selective H1-antihistamines with a range of projected half-lives in humans wer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e3dc05606f54d1888dffbf938419ff93
https://pubmed.ncbi.nlm.nih.gov/20188547
https://pubmed.ncbi.nlm.nih.gov/20188547
Autor:
Fabio C. Tucci, Lisa M. Hernández, Graham Beaton, Ajay Madan, Bin-Feng Li, Margaret J. Bradbury, Robert E. Petroski, Wilna J. Moree, Hua Wang, Dragan Marinkovic, Jinghua Yu, Jianyun Wen, Raymond S. Gross, Siobhan Malany, Florence Jovic, Paul D. Crowe, Said Zamani-Kord, Coon Timothy Richard, Zhihong O’Brien, Aida Sacaan, Sam R. J. Hoare
Publikováno v:
Journal of medicinal chemistry. 52(17)
Analogues of the known H(1)-antihistamine R-dimethindene were profiled as potential agents for the treatment of insomnia. Several highly selective compounds were efficacious in rodent sleep models. On the basis of overall profile, indene 1d and benzo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::808d5f5aa83baab00ef217e473199e63
https://pubmed.ncbi.nlm.nih.gov/19663387
https://pubmed.ncbi.nlm.nih.gov/19663387
Autor:
Mingzhu Zhang, Florence Jovic, Michael Johns, Troy Vickers, Joe A. Tran, Bin-Feng Li, Julie O'Brien, Margaret J. Bradbury, Jenny Wen, Rebecca R. Pick, John Saunders, Beth A. Fleck, Brian Dyck, Junko Tamiya, Alan C. Foster, Ajay Madan, Chen Chen, Jonathan Grey
Publikováno v:
Journal of medicinal chemistry. 51(22)
Thien-2-yl 1S,2R-milnacipran analogues were synthesized and characterized as norepinephrine/serotonin transporter inhibitors. These compounds possessed higher potencies than 1S,2R-milnacipran (2R-1) while maintaining low molecular weight and moderate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60d0e8d20fa88db3d804c4037d708a9c
https://pubmed.ncbi.nlm.nih.gov/18954038
https://pubmed.ncbi.nlm.nih.gov/18954038
Autor:
Beth A. Fleck, Florence Jovic, Junko Tamiya, Troy Vickers, Chen Chen, Brian Dyck, Alan C. Foster, Jonathan Grey, Rebecca R. Pick, Joe A. Tran, Mingzhu Zhang
Publikováno v:
Bioorganicmedicinal chemistry letters. 18(13)
Compounds with various activities and selectivities were discovered through structure-activity relationship studies of bicifadine analogs as monoamine transporter inhibitors. The norepinephrine-selective 2-thienyl compound S-6j was efficacious in a r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::77652beeb33e2bc39e5a9fe8cbef4497
https://pubmed.ncbi.nlm.nih.gov/18539031
https://pubmed.ncbi.nlm.nih.gov/18539031