Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Florence Frédéric"'
Autor:
Johannes J. L. van der Want, Florence Frédéric, Sonja Janmaat, Jean Mariani, Klaas A. Sjollema, Paul G.M. Luiten
Publikováno v:
Journal of comparative neurology, 512(4), 467-477. Wiley
Journal of Comparative Neurology
Journal of Comparative Neurology, Wiley, 2009, 512 (4), pp.467-77. ⟨10.1002/cne.21910⟩
Journal of Comparative Neurology, 2009, 512 (4), pp.467-77. ⟨10.1002/cne.21910⟩
Journal of Comparative Neurology
Journal of Comparative Neurology, Wiley, 2009, 512 (4), pp.467-77. ⟨10.1002/cne.21910⟩
Journal of Comparative Neurology, 2009, 512 (4), pp.467-77. ⟨10.1002/cne.21910⟩
In vivo, homozygous staggerer (Rora(sg/sg)) Purkinje cells (PCs) remain in an early stage of development with rudimentary spineless dendrites, associated with a lack of parallel fiber (PF) input and the persistence of multiple climbing fibers (CFs).
Publikováno v:
Journal of Neurogenetics. 16:111-123
Mice homozygous for the recessive, cerebellar affected mutations nervous and Purkinje cell degeneration display an almost complete loss of Purkinje cells during their first two postnatal months. We have recently shown a progressive and age-related lo
Autor:
Michael Becker-André, Francesca Capone, Nicole Delhaye-Bouchaud, Florence Frédéric, Jean Mariani, Mohamed Doulazmi
Publikováno v:
Developmental Brain Research. 127:165-174
The staggerer (Rora(sg/sg)) mutation is a deletion in the RORalpha gene, one member of a family of nuclear receptor genes related to the retinoic acid receptor. Recently Steinmayr et al. (Proc. Natl. Acad. Sci. USA 95 (1998) 3960) generated a RORalph
Autor:
Mohamed Doulazmi, Y. Lemaigre-Dubreuil, Florence Frédéric, Nadia Hadj-Sahraoui, Nicole Delhaye-Bouchaud, Jean Mariani
Publikováno v:
The Journal of Comparative Neurology. 411:267-273
The staggerer mutation causes dysgenesis of the cerebellar cortex in the homozygous mutant (Rorasg/Rorasg). The mutation acts intrinsically within the Purkinje cells (PCs), leading to cytological abnormalities and a severe deficit in the number of th
Autor:
C. Chianale, Florence Frédéric, Thierry Chautard, Nicole Delhaye-Bouchaud, Renaud Brochard, Jean Mariani, Charles Oliver, Emmanuelle E. Wollman
Publikováno v:
Neuroendocrinology. 66:341-347
Lurcher mutant mice which are mainly known for their cerebellar degeneration, also display a hyperinducibility of proinflammatory cytokines, such as interleukin-1alpha and beta (IL-1) and tumor necrosis factor alpha (TNF-alpha), in peripheral macroph
Autor:
Jean Mariani, Hadi Shojaeian Zanjani, Florence Frédéric, Nicole Delhaye-Bouchaud, Karl Herrup, Nadia Hadj-Sahraoui
Publikováno v:
Developmental Brain Research. 98:1-8
The cerebellum on the heterozygous (+/sg) staggerer mutant mouse has recently been proposed as a model system in which to study the genetic contribution to the normal process of central nervous system aging since there is significant loss of neurons
Autor:
Florence Frédéric, Bernard Brugg, Mohamed Doulazmi, Fatiha Boukhtouche, Jean Mariani, Isabelle Dusart
Publikováno v:
The Cerebellum
The Cerebellum, 2006, 5, pp.97-104
The Cerebellum, Springer, 2006, 5, pp.97-104
The Cerebellum, 2006, 5, pp.97-104
The Cerebellum, Springer, 2006, 5, pp.97-104
RORalpha (Retinoid-related Orphan Receptor) is a transcription factor belonging to the superfamily of nuclear receptors. The spontaneous staggerer (sg) mutation, which consists of a deletion in the Rora gene, has been shown to cause the loss of funct
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf5b86763aa255292d0e8b0506a863af
https://hal.science/hal-00078435/document
https://hal.science/hal-00078435/document
Autor:
Nicole Delhaye-Bouchaud, Nadia Hadj-Sahraoui, Jean Mariani, Florence Frédéric, Hadi Shojaeian Zanjani, Karl Herrup
Publikováno v:
Brain research. Developmental brain research. 126(2)
Staggerer (Rora(sg/sg)) is an autosomal mutation in an orphan nuclear hormone receptor gene, RORalpha, that acts intrinsically within the Purkinje cells and causes dysgenesis of the cerebellar cortex. Purkinje cell number is severely reduced, and the
Publikováno v:
Scopus-Elsevier
Homozygous mutant mice such as staggerer (sg/sg) or reeler (rl/rl) exhibit a marked ataxia associated with an atrophic cerebellum during the first postnatal weeks and a reduced number of Purkinje cells, the deficit reaching about 75% in sg/sg and 50%
Publikováno v:
Journal of Neuroscience Research; Jun2006, Vol. 83 Issue 8, p1525-1532, 8p