Zobrazeno 1 - 10
of 47
pro vyhledávání: '"Florence Depardieu"'
Autor:
Pengdbamba Dieudonné Zongo, Nicolas Cabanel, Guilhem Royer, Florence Depardieu, Alain Hartmann, Thierry Naas, Philippe Glaser, Isabelle Rosinski-Chupin
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-15 (2024)
Abstract Plasmids carrying antibiotic resistance genes (ARG) are the main mechanism of resistance dissemination in Enterobacterales. However, the fitness-resistance trade-off may result in their elimination. Chromosomal integration of ARGs preserves
Externí odkaz:
https://doaj.org/article/1ca4fb59dc414d5e8e54288f6a42ceeb
Autor:
Cyril Malbranke, William Rostain, Florence Depardieu, Simona Cocco, Rémi Monasson, David Bikard
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 11, p e1011621 (2023)
We present here an approach to protein design that combines (i) scarce functional information such as experimental data (ii) evolutionary information learned from a natural sequence variants and (iii) physics-grounded modeling. Using a Restricted Bol
Externí odkaz:
https://doaj.org/article/05b943bf0d4e4bd9be8e836d8265bc37
Publikováno v:
Scientific Reports, Vol 7, Iss 1, Pp 1-10 (2017)
Abstract The worrying rise of antibiotic resistance in pathogenic bacteria is leading to a renewed interest in bacteriophages as a treatment option. Novel sequencing technologies enable description of an increasing number of phage genomes, a critical
Externí odkaz:
https://doaj.org/article/f7de9c00525a49ff9dc9d8b9e894e1b8
Autor:
François Rousset, Lun Cui, Elise Siouve, Christophe Becavin, Florence Depardieu, David Bikard
Publikováno v:
PLoS Genetics, Vol 14, Iss 11, p e1007749 (2018)
High-throughput genetic screens are powerful methods to identify genes linked to a given phenotype. The catalytic null mutant of the Cas9 RNA-guided nuclease (dCas9) can be conveniently used to silence genes of interest in a method also known as CRIS
Externí odkaz:
https://doaj.org/article/6ed6c3dbaf1d451fae7e4100edbbe77a
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1005170 (2015)
Enterococcus faecalis BM4518 is resistant to vancomycin by synthesis of peptidoglycan precursors ending in D-alanyl-D-serine. In the chromosomal vanG locus, transcription of the resistance genes from the PYG resistance promoter is inducible and, upst
Externí odkaz:
https://doaj.org/article/52dabdaf41df4f59bfb439e524c3231e
Autor:
François Rousset, Florence Depardieu, Solange Miele, Julien Dowding, Anne-Laure Laval, Erica Lieberman, Daniel Garry, Eduardo P.C. Rocha, Aude Bernheim, David Bikard
Publikováno v:
Cell Host & Microbe
Cell Host & Microbe, 2022, 30 (5), pp.740-753.e5. ⟨10.1016/j.chom.2022.02.018⟩
Cell Host & Microbe, 2022, 30 (5), pp.740-753.e5. ⟨10.1016/j.chom.2022.02.018⟩
International audience; Bacteria carry diverse genetic systems to defend against viral infection, some of which are found within prophages where they inhibit competing viruses. Phage satellites pose additional pressures on phages by hijacking key vir
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::480ef1d8d20ca548d7865339e2748b8d
https://hal-pasteur.archives-ouvertes.fr/pasteur-04075930/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-04075930/document
Autor:
Florence Depardieu, David Bikard
Publikováno v:
Methods
Methods, Elsevier, 2020, 172, pp.61-75. ⟨10.1016/j.ymeth.2019.07.024⟩
Methods, 2020, 172, pp.61-75. ⟨10.1016/j.ymeth.2019.07.024⟩
Methods, Elsevier, 2020, 172, pp.61-75. ⟨10.1016/j.ymeth.2019.07.024⟩
Methods, 2020, 172, pp.61-75. ⟨10.1016/j.ymeth.2019.07.024⟩
International audience; The catalytic null mutant of the Cas9 endonuclease from the bacterial CRISPR immune system, known as dCas9, can be guided by a small RNA to bind DNA sequences of interest and block gene transcription in a strategy known as CRI
Autor:
Alex Hawkins-Hooker, Arthur Chen, David Bikard, Guillaume Couairon, Florence Depardieu, Sebastien Baur
Publikováno v:
PLoS Computational Biology
PLoS Computational Biology, 2021, 17 (2), pp.e1008736. ⟨10.1371/journal.pcbi.1008736⟩
PLoS Computational Biology, Public Library of Science, 2021, 17 (2), pp.e1008736. ⟨10.1371/journal.pcbi.1008736⟩
PLoS Computational Biology, Vol 17, Iss 2, p e1008736 (2021)
PLoS Computational Biology, 2021, 17 (2), pp.e1008736. ⟨10.1371/journal.pcbi.1008736⟩
PLoS Computational Biology, Public Library of Science, 2021, 17 (2), pp.e1008736. ⟨10.1371/journal.pcbi.1008736⟩
PLoS Computational Biology, Vol 17, Iss 2, p e1008736 (2021)
The vast expansion of protein sequence databases provides an opportunity for new protein design approaches which seek to learn the sequence-function relationship directly from natural sequence variation. Deep generative models trained on protein sequ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5955b622447ca55f7098b466df9b8783
https://hal-pasteur.archives-ouvertes.fr/pasteur-03263932/document
https://hal-pasteur.archives-ouvertes.fr/pasteur-03263932/document
Autor:
Elise Siouve, Christophe Bécavin, François Rousset, David Bikard, Florence Depardieu, Lun Cui
Publikováno v:
PLoS Genetics
PLoS Genetics, Public Library of Science, 2018, 14 (11), pp.e1007749. ⟨10.1371/journal.pgen.1007749⟩
PLoS Genetics, 2018, 14 (11), pp.e1007749. ⟨10.1371/journal.pgen.1007749⟩
PLOS Genetics
PLoS Genetics, Vol 14, Iss 11, p e1007749 (2018)
PLoS Genetics, Public Library of Science, 2018, 14 (11), pp.e1007749. ⟨10.1371/journal.pgen.1007749⟩
PLoS Genetics, 2018, 14 (11), pp.e1007749. ⟨10.1371/journal.pgen.1007749⟩
PLOS Genetics
PLoS Genetics, Vol 14, Iss 11, p e1007749 (2018)
High-throughput genetic screens are powerful methods to identify genes linked to a given phenotype. The catalytic null mutant of the Cas9 RNA-guided nuclease (dCas9) can be conveniently used to silence genes of interest in a method also known as CRIS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::39bd2dd7dfe044f60f7065f2594cd179
https://hal-pasteur.archives-ouvertes.fr/pasteur-01975438/file/pgen.1007749.pdf
https://hal-pasteur.archives-ouvertes.fr/pasteur-01975438/file/pgen.1007749.pdf
Bacteriophages are the most abundant viruses on earth and display an impressive genetic as well as morphologic diversity. Among those, the most common order of phages is the Caudovirales, whose viral particles packages linear double stranded DNA (dsD
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd52850f336fd874b121f0520babb899