Zobrazeno 1 - 10
of 57
pro vyhledávání: '"Florence Débarre"'
Publikováno v:
PLoS Genetics, Vol 20, Iss 5, p e1011262 (2024)
Engineered gene-drive techniques for population modification and/or suppression have the potential for tackling complex challenges, including reducing the spread of diseases and invasive species. Gene-drive systems with low threshold frequencies for
Externí odkaz:
https://doaj.org/article/51149145c9134ed7a0d57273d4e7497f
Publikováno v:
PLoS Computational Biology, Vol 20, Iss 3, p e1011934 (2024)
While the first infection of an emerging disease is often unknown, information on early cases can be used to date it. In the context of the COVID-19 pandemic, previous studies have estimated dates of emergence (e.g., first human SARS-CoV-2 infection,
Externí odkaz:
https://doaj.org/article/1a4109480a884ec08ea2b39699bfd667
Autor:
François Blanquart, Clémence Abad, Joevin Ambroise, Mathieu Bernard, Florence Débarre, Jean-Marc Giannoli, Thomas Rey, Vincent Vieillefond
Publikováno v:
International Journal of Infectious Diseases, Vol 133, Iss , Pp 89-96 (2023)
Objectives: We aimed to quantify how the vaccine efficacy of BNT162b2, messenger RNA-1273, AD26.COV2-S, and ChAdOx1 nCoV-19 against detected infection by the SARS-CoV-2 Delta and Omicron variants varied by time since the last dose, vaccine scheme, ag
Externí odkaz:
https://doaj.org/article/150e3b2ec4b54246bd836604c815cd31
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 8, p e1011364 (2023)
The use of an antibiotic may lead to the emergence and spread of bacterial strains resistant to this antibiotic. Experimental and theoretical studies have investigated the drug dose that minimizes the risk of resistance evolution over the course of t
Externí odkaz:
https://doaj.org/article/ff0f8c0c0a694825b865d5d9901e42c9
Publikováno v:
eLife, Vol 11 (2022)
Evaluating the characteristics of emerging SARS-CoV-2 variants of concern is essential to inform pandemic risk assessment. A variant may grow faster if it produces a larger number of secondary infections (“R advantage”) or if the timing of second
Externí odkaz:
https://doaj.org/article/a6e5d758ac4d4789a2b828db98f332c5
Publikováno v:
G3: Genes, Genomes, Genetics, Vol 10, Iss 9, Pp 3403-3415 (2020)
CRISPR-based homing gene drive is a genetic control technique aiming to modify or eradicate natural populations. This technique is based on the release of individuals carrying an engineered piece of DNA that can be preferentially inherited by the pro
Externí odkaz:
https://doaj.org/article/77b14336f4b7418783cf2bc932a12b85
Autor:
Peter Czuppon, Florence Débarre, Antonio Gonçalves, Olivier Tenaillon, Alan S Perelson, Jérémie Guedj, François Blanquart
Publikováno v:
PLoS Computational Biology, Vol 17, Iss 3, p e1008752 (2021)
Repurposed drugs that are safe and immediately available constitute a first line of defense against new viral infections. Despite limited antiviral activity against SARS-CoV-2, several drugs are being tested as medication or as prophylaxis to prevent
Externí odkaz:
https://doaj.org/article/50b40dd9227d45e4be233cd55c023ced
Publikováno v:
PLoS Computational Biology, Vol 9, Iss 5, p e1003039 (2013)
Although bubonic plague is an endemic zoonosis in many countries around the world, the factors responsible for the persistence of this highly virulent disease remain poorly known. Classically, the endemic persistence of plague is suspected to be due
Externí odkaz:
https://doaj.org/article/16b11a91176b47c5a2f8fd01893aa50e
Publikováno v:
PLoS Computational Biology, Vol 5, Iss 4, p e1000337 (2009)
How can we optimize the use of drugs against parasites to limit the evolution of drug resistance? This question has been addressed by many theoretical studies focusing either on the mixing of various treatments, or their temporal alternation. Here we
Externí odkaz:
https://doaj.org/article/be47087a55bf4b419f1b1712acfeeb80
The use of an antibiotic often leads to the emergence and spread of bacterial strains resistant to this antibiotic. Experimental and theoretical studies have investigated the drug dose that minimizes the risk of resistance evolution over the course o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7e70e97c76e788e9c6df95f7976034da
https://doi.org/10.1101/2023.02.20.529188
https://doi.org/10.1101/2023.02.20.529188
