Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Florence Clénet"'
Publikováno v:
Behavioural Brain Research. 166:140-149
The sensitization of animal models of anxiety is of great importance to detect potential anxiolytic drugs. Our goal was to evaluate the influence of manipulations of the light/dark cycle on the basal anxious behaviour of mice and the efficacy of two
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bcf7dd16e11a21cd130394ca1726e86
https://doi.org/10.1016/j.bbr.2005.07.018
https://doi.org/10.1016/j.bbr.2005.07.018
Publikováno v:
Behavioural Brain Research. 158:339-348
5-HT-moduline is an endogenous tetrapeptide, which acts specifically as an antagonist of 5-HT1B auto- and heteroreceptors. HG1 is an ethyl arylmethyloxypiperidine acetate and an antagonist of 5-HT-moduline, which has no 5-HT-moduline agonist effect.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::95dbac6426ccb4c93327bfc2125a49ab
https://doi.org/10.1016/j.bbr.2004.09.015
https://doi.org/10.1016/j.bbr.2004.09.015
Publikováno v:
European Neuropsychopharmacology. 11:145-152
Several recent studies have demonstrated that 5-HT 1A , 5-HT 1B and 5-HT 3 receptors were implicated in the mechanism of action of antidepressants in the mouse forced swimming test. Despite extensive evidence for a role of 5-HT 2C receptors in depres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5eb3e4b956a2cd342f926d4a4469221
https://doi.org/10.1016/s0924-977x(01)00078-5
https://doi.org/10.1016/s0924-977x(01)00078-5
Publikováno v:
Behavioural Brain Research. 118:77-83
The effect of inositol as an antidepressant was previously demonstrated in both animal models of depression-like behavior and in clinical trials. Unlike most antidepressant drugs, inositol does not have a clear target in the synapse and was not demon
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e27a511c5588b2768a8d4dc0a75ae166
https://doi.org/10.1016/s0166-4328(00)00314-4
https://doi.org/10.1016/s0166-4328(00)00314-4
Publikováno v:
Human Psychopharmacology: Clinical and Experimental. 16:9-21
Animal models of depression have been utilised to screen novel compounds with antidepressant potential although uncertainty lingers concerning their clinical relevance. In order for a model to be considered of any value, it must possess predictive va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4afad391484849d014f3e7eb63f945aa
https://doi.org/10.1002/hup.178
https://doi.org/10.1002/hup.178
Publikováno v:
Psychopharmacology. 179(2)
The selective serotonin reuptake inhibitors (SSRIs) and the serotonin and noradrenaline reuptake inhibitors (SNRIs) increase synaptic levels of serotonin, leading to an increased activation of a multitude of specific postsynaptic 5-HT receptors. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e9a49555e3584ba8c4b93b2811cb8d59
https://pubmed.ncbi.nlm.nih.gov/15821956
https://pubmed.ncbi.nlm.nih.gov/15821956
Publikováno v:
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology. 14(6)
HG1 is a new 5-HT-moduline antagonist which is itself an endogenous tetrapeptide specifically acting as an antagonist of 5-HT1B auto- and heteroreceptors. Blockade of endogenous 5-HT-moduline might provoke anxiolysis, so it could be a new therapeutic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8758d51e29cbbfecf6c235c33601e9b1
https://pubmed.ncbi.nlm.nih.gov/15589384
https://pubmed.ncbi.nlm.nih.gov/15589384
Publikováno v:
Psychopharmacology. 159(1)
Rationale: Microdialysis, binding and behavioural studies have shown that the dopaminergic system plays a role in antidepressant treatment. Objectives: The present study determined whether the antidepressant-like effects of selective serotonin reupta
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::78a1f24747e4e0cdb6e23ba681a2c1ea
https://pubmed.ncbi.nlm.nih.gov/11797068
https://pubmed.ncbi.nlm.nih.gov/11797068