Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Florence Binlich"'
Autor:
Reuben Benjamin, Charlotte Graham, Deborah Yallop, Agnieszka Jozwik, Oana C Mirci-Danicar, Giovanna Lucchini, Danielle Pinner, Nitin Jain, Hagop Kantarjian, Nicolas Boissel, Marcela V Maus, Matthew J Frigault, André Baruchel, Mohamad Mohty, Athos Gianella-Borradori, Florence Binlich, Svetlana Balandraud, Fabien Vitry, Elisabeth Thomas, Anne Philippe, Sylvain Fouliard, Sandra Dupouy, Ibtissam Marchiq, Maria Almena-Carrasco, Nicolas Ferry, Sylvain Arnould, Cyril Konto, Paul Veys, Waseem Qasim, Antonio Pagliuca, Ghulam Mufti, Piers Patten, Shireen Kassam, Stephen Devereux, Majid Kazmi, Kirsty Cuthill, Victoria Potter, Andrea Kuhnl, Victoria Metaxa, Laarni Bonganay, Orla Stewart, Rose Ellard, Lorraine Catt, Jen Lewis, Farzin Farzaneh, Jackie Chappell, Alice Mason, Vicky Chu, Alan Dunlop, Adeel Saleem, Gary Cheung, Helena Munro, Elka Giemza, Oana Ciocarlie, Jan Chu, Persis Amrolia, Kanchan Rao, Robert Chiesa, Juliana Silva, Annette Hill, Maria Finch, Lindsey Young, Harvinder Hara, Sujith Samarasinghe, Anupama Rao, Ajay Vora, Kimberley Gilmour, Christine Rivat, Clare Murphy, Gulrukh Ahsan, Rasha Said Shamsah, Jesmina James, Sarah Inglott, Gary Wright, Stuart Adams, Natalia Izotova, Marina Konopleva, William Wierda, Elias Jabbour, Partow Kebrieai, Emily Jones, Kara McGee, Marcela Maus, Matthew Frigault, Jami Brown, Vesselina Toncheva, Keagan Casey, Hanno Hock, Meaghan A McKeown, Richard Mathews, Thomas Spitzer, Emmanuel Raffoux, Etienne Lengliné, Raphael Itzykson, Florence Rabian, Jérôme Larghero, Isabelle Madelaine, Elie Azoulay, Emmanuelle Clappier, Sophie Caillat-Zucman, Martine Meunier, Karine Celli-Lebras, Marie-Thérèse Tremorin, Karima Yakouben, Françoise Mechinaud-Heloury, Audrey Grain, Aurélia Alimi, Julie Roupret, Delphine Chaillou, Hélène Cavé, Aurelie Caye-Eude, Odile Fenneteau, Elodie Lainey, Jerome Naudin, Eolia Brissot, Remy Dulery, Florent Malard, Clémence Mediavilla, Agnès Bonnin, Anne Vekhoff, Tounes Ledraa, Anne Daguenel-Nguyen
Publikováno v:
The Lancet. 396:1885-1894
Summary Background Genome-edited donor-derived allogeneic anti-CD19 chimeric antigen receptor (CAR) T cells offer a novel form of CAR-T-cell product that is available for immediate clinical use, thereby broadening access and applicability. UCART19 is
Autor:
Reuben Benjamin, Nitin Jain, Marcela V Maus, Nicolas Boissel, Charlotte Graham, Agnieszka Jozwik, Deborah Yallop, Marina Konopleva, Matthew J Frigault, Takanori Teshima, Koji Kato, Floriane Boucaud, Svetlana Balandraud, Athos Gianella-Borradori, Florence Binlich, Ibtissam Marchiq, Sandra Dupouy, Maria Almena-Carrasco, Matthieu Pannaux, Sylvain Fouliard, Eolia Brissot, Mohamad Mohty, Laarni Bonganay, Lorraine Catt, Jackie Chappell, Gary Cheung, Vicky Chu, Kirsty Cuthill, Steven Devereux, Alan Dunlop, Rose Ellard, Farzin Farzeneh, Najeem Folarin, Elka Giemza, Shireen Kassam, Majid Kazmi, Andrea Kuhnl, Jen Lewis, Maria Liskova, Alice Mason, Victoria Metaxa, Ghulam Mufti, Helena Munro, Antonio Pagliuca, Piers Patten, Victoria Potter, Carmel Rice, Adeel Saleem, Robin Sanderson, Orla Stewart, Elias Jabbour, Emily Jones, Hagop Kantarjian, Partow Kebriaei, Kara McGee, William Wierda, Jami Brown, Keagan Casey, Matthew Frigault, Hanno Hock, Richard Mathews, Marcela Maus, Meaghan A McKeown, Thomas Spitzer, Vesselina Toncheva, Elie Azoulay, Sophie Caillat-Zucman, Karine Celli-Lebras, Emmanuelle Clappier, Raphael Itzykson, Jérôme Larghero, Etienne Lengliné, Isabelle Madelaine, Martine Meunier, Florence Rabian, Emmanuel Raffoux, Marie-Thérèse Tremorin, Agnes Bonnin, Anne Daguenel-Nguyen, Remy Dulery, Tounes Ledraa, Florent Malard, Clemence Mediavilla, Anne Vekhoff
Publikováno v:
The Lancet. Haematology. 9(11)
The prognosis for adults with relapsed or refractory B-cell acute lymphoblastic leukaemia remains poor. UCART19, an allogeneic genome-edited anti-CD19 chimeric antigen receptor (CAR) T-cell product derived from healthy donors and available for immedi
Autor:
Elly Barry, Gilles Vassal, Thomas Winkler, Gregory H. Reaman, Kerri Nottage, Anne Borgman, Florence Binlich, Dirk Reinhardt, Jan-Henning Klusmann, Delphine Heenen, C. Michel Zwaan, Silvia Mappa, Bouchra Benettaib, Koen Norga, Su Young Kim, Gertjan J.L. Kaspers, Malcolm A. Smith, Peter C. Adamson, Renaud Capdeville, Lynley V. Marshall, Linda Fogelstrand, David Delgado, Mark W. Kieran, Sarah K. Tasian, E. Anders Kolb, Julie Guillot, Paula Goodman Fraenkel, Hesham Mohamed, G. Lesa, Henrik Hasle, Andrew D.J. Pearson, Franca Ligas, J. Morris, Stephen J. Simko, Todd M. Cooper, Dominik Karres, Erica Brivio, Andrew S. Moore, Douglas V. Faller, Nicole Scobie
Publikováno v:
European journal of cancer (Oxford, England : 1990)
European Journal of Cancer
European Journal of Cancer
Purpose: The current standard-of-care for front-line therapy for acute myeloid leukaemia (AML) results in short-term and long-term toxicity, but still approximately 40% of children relapse. Therefore, there is a major need to accelerate the evaluatio
Autor:
Xavier Paoletti, Matthieu Roustit, Florence Binlich, Bruno Laviolle, Cécile Fouret, Jehan-Michel Behier, Olivier Delaitre, Silvy Laporte, Houda Miadi-Fargier, Serge Bureau, Catherine Cornu, Nathalie Varoqueaux, Anne d’Andon, Tabassome Simon, Michel Cucherat, Natalie Hoog Labouret, Eric Vicaut, Jérémie Westerloppe
Publikováno v:
Therapies
Therapies, 2020, 75 (1), pp.21-27. ⟨10.1016/j.therap.2019.11.007⟩
Thérapie
Thérapie, EDP Sciences, 2020, 75 (1), pp.21-27. ⟨10.1016/j.therap.2019.11.007⟩
Therapies, 2020, 75 (1), pp.21-27. ⟨10.1016/j.therap.2019.11.007⟩
Thérapie
Thérapie, EDP Sciences, 2020, 75 (1), pp.21-27. ⟨10.1016/j.therap.2019.11.007⟩
International audience; Single-arm studies are sometimes used as pivotal studies but they have methodological limitations which prevent them from obtaining the high level of reliability as for a randomised controlled study which remains the gold stan
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6656d0f20895c4771222f6681e89b08f
https://univ-rennes.hal.science/hal-02498637/document
https://univ-rennes.hal.science/hal-02498637/document
Autor:
Florence Binlich, Silvy Laporte, Houda Miadi-Fargier, Jérémie Westerloppe, Jehan-Michel Behier, Olivier Delaitre, Catherine Cornu, Anne d’Andon, Natalie Hoog Labouret, Xavier Paoletti, Eric Vicaut, Nathalie Varoqueaux, Tabassome Simon, Bruno Laviolle, Matthieu Roustit, Michel Cucherat, Cécile Fouret, Serge Bureau
Publikováno v:
Therapies
Therapies, 2020, 75 (1), pp.13-19. ⟨10.1016/j.therap.2019.12.002⟩
Thérapie
Thérapie, EDP Sciences, 2020, 75 (1), pp.13-19. ⟨10.1016/j.therap.2019.12.002⟩
Therapies, 2020, 75 (1), pp.13-19. ⟨10.1016/j.therap.2019.12.002⟩
Thérapie
Thérapie, EDP Sciences, 2020, 75 (1), pp.13-19. ⟨10.1016/j.therap.2019.12.002⟩
National audience; Les études mono-bras sont parfois utilisées comme études pivots mais elles présentent des limites méthodologiques qui ne leur permettent pas d’obtenir un niveau de fiabilité élevé comme peut l’être celui de l’essai c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28f6843cea5859c7172cebbf777f47b9
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02498631
https://hal-univ-rennes1.archives-ouvertes.fr/hal-02498631
Autor:
Florence Binlich, Bourras-Rezki Bengoudifa, Vania Hungria, Robert L. Schlossman, Philippe Moreau, Jesús F. San-Miguel, Monika Sopala, Meral Beksac, Paul G. Richardson, Hermann Einsele, Wiesław Wiktor Jędrzejczak, Sung-Soo Yoon, Andreas Günther, Thanyaphong Na Nakorn, Jian Hou, Ashraf Elghandour, Noppadol Siritanaratkul, Meletios A. Dimopoulos, Jae H. Lee, Sagar Lonial
Publikováno v:
The Lancet Haematology. 3:e506-e515
Summary Background Panobinostat plus bortezomib and dexamethasone significantly increased median progression-free survival compared with placebo plus bortezomib and dexamethasone in the phase 3 PANORAMA 1 trial. Here, we present the final overall sur
Autor:
Rong Lin, Masayuki Hino, Hirohiko Shibayama, Claudia Corrado, Song Mu, Florence Binlich, Takeshi Tajima, Edward Waldron, Yoshiaki Kuroda, Kenshi Suzuki
Publikováno v:
European Journal of Clinical Pharmacology
Purpose Panobinostat, a potent pan-deacetylase inhibitor, improved progression-free survival (PFS) in patients with relapsed and refractory multiple myeloma when combined with bortezomib and dexamethasone in a phase 3 trial, PANORAMA-1. This study ai
Autor:
Paolo Corradini, Enrique M. Ocio, Krzysztof Warzocha, Tontanai Numbenjapon, Suporn Chuncharunee, Hans Salwender, Jonathan L. Kaufman, Tatiana Shelekhova, Monika Sopala, Ming Chung Wang, Darrell White, Robert L. Schlossman, Meral Beksac, Thanyaphong Na Nakorn, Jian Hou, Hermann Einsele, Bourras Rezki Bengoudifa, V. Hungria, Kwee Yong, Daryl Tan, Jesús F. San-Miguel, Meletios A. Dimopoulos, Sung-Soo Yoon, Joan Bladé, Florence Binlich, Peter Gimsing, Wiesław Wiktor Jędrzejczak, Stefano Pulini, Richard Leblanc, Andreas Günther, Wenming Chen, Je-Jung Lee, Hareth Nahi, Jamie Cavenagh, Ashraf Elghandour, Ljupco Veskovski, Lugui Qiu, Sagar Lonial, Paul G. Richardson, Javier de la Rubia, Jae Hoon Lee, Claudia Corrado, Noppadol Siritanaratkul, Philippe Moreau, Sang Kyun Sohn
Publikováno v:
LANCET ONCOLOGY
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
r-IIS La Fe. Repositorio Institucional de Producción Científica del Instituto de Investigación Sanitaria La Fe
instname
Background Panobinostat is a potent oral pan-deacetylase inhibitor that in preclinical studies has synergistic antimyeloma activity when combined with bortezomib and dexamethasone. We aimed to compare panobinostat, bortezomib, and dexamethasone with
Autor:
Robert L. Schlossman, Ashraf Elghandour, Noppadol Siritanaratkul, Wiesław Wiktor Jędrzejczak, V. Hungria, Paul G. Richardson, Sung-Soo Yoon, Philippe Moreau, Jesús F. San-Miguel, Thanyaphong Na Nakorn, Jian Hou, Jae Hoon Lee, Claudia Corrado, Monika Sopala, Andreas Guenther, Florence Binlich, Hermann Einsele, Bourras-Rezki Bengoudifa, Sagar Lonial, Meletios A. Dimopoulos, Meral Beksac
Panobinostat is a potent pan-deacetylase inhibitor that affects the growth and survival of multiple myeloma (MM) cells through alteration of epigenetic mechanisms and protein metabolism. Panobinostat plus bortezomib and dexamethasone (PAN-BTZ-Dex) le
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53a38ef05d3afe9edeaea36b3d88ef0e
https://europepmc.org/articles/PMC4760132/
https://europepmc.org/articles/PMC4760132/
Autor:
Victoria Potter, Alan Dunlop, Premal H. Patel, Frédéric Dubois, Charlotte Graham, Agnieszka Jozwik, Florence Binlich, Svetlana Balandraud, Reuben Benjamin, Shireen Kassam, Victoria Metaxa, Stephen Devereux, Sandra Dupouy, Piers E.M. Patten, Anne Philippe, Amina Zinai, Rose Ellard, Cyril Konto, Antonio Pagliuca, Ghulam J. Mufti, Farzin Farzaneh, Deborah Yallop, Orla Stewart
Publikováno v:
Blood. 130:887-887
Background UCART19 is a genetically modified T-cell product manufactured from non-HLA matched healthy donor cells. Lentiviral-transduced CAR T-cells express (1) an anti-CD19 CAR (anti-CD19 scFv- 41BB- CD3ζ) and (2) an RQR8 "safety switch" that is in