Zobrazeno 1 - 10
of 12
pro vyhledávání: '"Florence Bachelot"'
Autor:
Coralie Courtinard, Sophie Gourgou, William Jacot, Matthieu Carton, Olivier Guérin, Laure Vacher, Aurélie Bertaut, Marie-Cécile Le Deley, David Pérol, Patricia Marino, Christelle Levy, Lionel Uwer, Geneviève Perrocheau, Renaud Schiappa, Florence Bachelot, Damien Parent, Mathias Breton, Thierry Petit, Thomas Filleron, Agnès Loeb, Simone Mathoulin Pélissier, Mathieu Robain, Suzette Delaloge, Carine Bellera
Publikováno v:
BMC Medicine, Vol 21, Iss 1, Pp 1-13 (2023)
Abstract Background Overall survival (OS) is the gold standard endpoint to assess treatment efficacy in cancer clinical trials. In metastatic breast cancer (mBC), progression-free survival (PFS) is commonly used as an intermediate endpoint. Evidence
Externí odkaz:
https://doaj.org/article/95e587a2739d4813945eb54f7074bcab
Autor:
Justyne Vetel, Florence Bachelot, Morgane Dos Santos, Nathalie Mougenot, Sophie Nadaud, Nadine Suffee, Virginie Monceau
Publikováno v:
Archives of Cardiovascular Diseases Supplements. 15:227-228
Autor:
Florian Saliou, Hélène Quelquejay, Florence Bachelot, Chloe Brizais, Goran Riazi, Oumaima Chamkhi, Teni Ebrahiman Chiusa, Eric Morel, Virginie Monceau
Publikováno v:
Archives of Cardiovascular Diseases Supplements. 14:186
Autor:
Thierry Taverne, Nadia Loiseau, Sandrine Lacombe, Eric Beausoleil, Laurent Desire, Hélène Peillon, Virginie Picard, Bertrand Leblond, Dominique Drouin, Fabien Schweighoffer, Florence Bachelot, Jérôme Bourdin, Catherine De Oliveira
Publikováno v:
Journal of Biological Chemistry. 280:37516-37525
beta-Amyloid peptides (Abeta) that form the senile plaques of Alzheimer disease consist mainly of 40- and 42-amino acid (Abeta 40 and Abeta 42) peptides generated from the cleavage of the amyloid precursor protein (APP). Generation of Abeta involves
Autor:
Matthew P. Pando, Cedric Chauvignac, Laurent Desire, Bertrand Leblond, Anne-Sophie Belzacq-Casagrande, Emeline Throo, Eric Beausoleil, Florence Maurier-Mahé, Thierry Taverne, Séverine Coutadeur, Angélique Petibon, Laure Pognante, Catherine De Oliveira, Florence Bachelot
Publikováno v:
Investigational new drugs. 31(2)
Tumor blood vessels are an important emerging target for anticancer therapy. Here, we characterize the in vitro antiproliferative and antiangiogenic properties of the synthetic small molecule, 7-ethoxy-4-(3,4,5-trimethoxybenzyl)isoquinolin-8-amine di
Structure-activity relationship of isoform selective inhibitors of Rac1/1b GTPase nucleotide binding
Autor:
Thierry Taverne, Rachel Carton, Bertrand Leblond, Laurent Desire, Diego Pallares, Laure Pognante, Fabien Schweighoffer, Cedric Chauvignac, Eric Beausoleil, Sandrine Lacombe, Nathalie Lambeng, Séverine Coutadeur, Hélène Peillon, Florence Bachelot, Catherine De Oliveira, Virginie Picard
Publikováno v:
Bioorganicmedicinal chemistry letters. 19(19)
The synthesis of a series of berberine, phenantridine and isoquinoline derivatives was realized to explore their Rho GTPase nucleotide inhibitory activity. The compounds were evaluated in a nucleotide binding competition assay against Rac1, Rac1b, Cd
Autor:
Cedric Chauvignac, Thierry Taverne, Laurent Desire, Eric Beausoleil, Hélène Peillon, Bertr Leblond, Nadia Loiseau, Nathalie Lambeng, Rachel Carton, Catherine De Oliveira, Florence Bachelot, Séverine Coutadeur, Fabien Schweighoffer
Publikováno v:
Alzheimer's & Dementia. 4
Autor:
Bertrand Leblond, Anne-Sophie Casagrande, Florence Mahé, Laurent Desire, Matthew P. Pando, Thierry Besson, Emeline Throo, Florence Bachelot
Publikováno v:
Cancer Research. 74:2620-2620
The dual-specificity tyrosine phosphorylated and regulated kinase Mirk/DYRK1B belongs to an evolutionary conserved family of kinases involved in the control of growth and development. DYRK1B has low level of expression in most normal cell types but i
Autor:
Hervé, Lilliu, Denise, Stevens, Catherine, Brun, Julie, Morel, Claude Le, Pen, Julia, Bonastre, Florence, Bachelot, Christian, Davesne, Annie, Gentile, Eric, Hirlimann, Jean-Christophe, Sabourin, Jacques, Berlie, Jacques, Rouëssé
Publikováno v:
Bulletin du cancer. 89(6)
Breast cancer is one of the major causes of premature death for women. Its cost management is important for both the national health insurance and the individual health care providers.The objective of this study was to assess the global medical cost
Autor:
Florence Bachelot, Laurent Desire, Bertrand Leblond, Séverine Coutadeur, Thierry Besson, Matthew P. Pando, Anne-Sophie Casagrande
Publikováno v:
Cancer Research. 73:2165-2165
Dual-specificity tyrosine-phosphorylated and regulated kinases (DYRK) is a family of conserved protein kinases which mediate survival and differentiation in normal tissues like skeletal muscle for Mirk/Dyrk1B or neuronal cells for Dyrk1A. Among the f