Induced Cognitive Impairments Reversed by Grafts of Neural Precursors: A Longitudinal Study in a Macaque Model of Parkinson's Disease

Autor: Florence Wianny, Kwamivi Dzahini, Karim Fifel, Charles Robert Eden Wilson, Agnieszka Bernat, Virginie Dolmazon, Pierre Misery, Camille Lamy, Pascale Giroud, Howard Michael Cooper, Kenneth Knoblauch, Emmanuel Procyk, Henry Kennedy, Pierre Savatier, Colette Dehay, Julien Vezoli

Publikováno v: Advanced Science, Vol 9, Iss 10, Pp n/a-n/a (2022)

Abstract Parkinson's disease (PD) evolves over an extended and variable period in humans; years prior to the onset of classical motor symptoms, sleep and biological rhythm disorders develop, significantly impacting the quality‐of‐life of patients

Externí odkaz: https://doaj.org/article/6c2033c46149414da9b32938aff53854

Induced Cognitive Impairments Reversed by Grafts of Neural Precursors: a Longitudinal Study in a Macaque Model of Parkinson’s Disease

Autor: Howard M. Cooper, Kwamivi Dzahini, Colette Dehay, Virginie Dolmazon, Karim Fifel, Julien Vezoli, Pierre Misery, Pierre Savatier, Charles R.E. Wilson, Florence Wianny, Camille Lamy, Emmanuel Procyk, Agnieszka Bernat, Henry Kennedy

Publikováno v: Advanced Science

Parkinson’s disease (PD) evolves over an extended and variable period in humans; several years prior to the onset of classical motor symptoms, cognitive deficits as well as sleep and biological rhythm disorders develop and worsen with disease progr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::852965109628c24112230e4d7edd6eda
https://hal.archives-ouvertes.fr/hal-03436232

Apoptosis, G1 Phase Stall, and Premature Differentiation Account for Low Chimeric Competence of Human and Rhesus Monkey Naive Pluripotent Stem Cells

Autor: Anaïs Moulin, Irène Aksoy, Manon Dirheimer, Thierry Joly, Guillaume Marcy, Florence Wianny, Pierre-Yves Bourillot, Chloé Mayère, Olivier Raineteau, Marielle Afanassieff, Cian J. Lynch, Angèle Bellemin-Ménard, Véronique Cortay, Nathalie Doerflinger, Etienne Masfaraud, Manuel Serrano, Pierre Savatier, Colette Dehay, Cloé Rognard

Publikováno v: Stem Cell Reports
Stem Cell Reports, Elsevier, 2021, 16 (1), pp.56-74. ⟨10.1016/j.stemcr.2020.12.004⟩
Dipòsit Digital de la UB
Universidad de Barcelona
Stem Cell Reports, 2021, 16 (1), pp.56-74. ⟨10.1016/j.stemcr.2020.12.004⟩

Summary After reprogramming to naive pluripotency, human pluripotent stem cells (PSCs) still exhibit very low ability to make interspecies chimeras. Whether this is because they are inherently devoid of the attributes of chimeric competency or becaus

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8817c32effe02417179b1e4cfb3000e4
https://hal.inrae.fr/hal-03341220

Determinants of primate neurogenesis and the deployment of top-down generative networks in the cortical hierarchy

Autor: Henry, Kennedy, Florence, Wianny, Colette, Dehay

Publikováno v: Current opinion in neurobiology. 66

What I cannot create I do not understand - Richard Feynman 1978 Because primate cortical development exhibits numerous specific features, the mouse is an imperfect model for human cortical development. Expansion of supragranular neurons is an evoluti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::14ab79276a4aad26871703c0104d30b0
https://pubmed.ncbi.nlm.nih.gov/33099180

Bridging the Gap between Mechanics and Genetics in Cortical Folding: ECM as a Major Driving Force

Autor: Florence Wianny, Henry Kennedy, Colette Dehay

Publikováno v: Neuron
Neuron, Elsevier, 2018, 99 (4), pp.625-627. ⟨10.1016/j.neuron.2018.08.012⟩

Folding of the cerebral cortex results from interrelated biological and mechanical processes that are incompletely understood. In this issue, Long et al. identify the key roles of HAPLN1, lumican, collagen I, and HA in relationship with changes in ti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8dcf87673e9f2f145be17b505f84322c
https://doi.org/10.1016/j.neuron.2018.08.012