Transient Receptor Potential (TRP) Ion Channels Involved in Malignant Glioma Cell Death and Therapeutic Perspectives

Autor: Florence Lefranc

Publikováno v: Frontiers in Cell and Developmental Biology, Vol 9 (2021)

Among the most biologically, thus clinically, aggressive primary brain tumors are found malignant gliomas. Despite recent advances in adjuvant therapies, which include targeted and immunotherapies, after surgery and radio/chemotherapy, the tumor is r

Externí odkaz: https://doaj.org/article/33cf879b22b64858b2ed5256570a555d

Sensitization of glioblastoma tumor micro-environment to chemo- and immunotherapy by Galectin-1 intranasal knock-down strategy

Autor: Matthias Van Woensel, Thomas Mathivet, Nathalie Wauthoz, Rémi Rosière, Abhishek D. Garg, Patrizia Agostinis, Véronique Mathieu, Robert Kiss, Florence Lefranc, Louis Boon, Jochen Belmans, Stefaan W. Van Gool, Holger Gerhardt, Karim Amighi, Steven De Vleeschouwer

Publikováno v: Scientific Reports, Vol 7, Iss 1, Pp 1-14 (2017)

Abstract In this study, we evaluated the consequences of reducing Galectin-1 (Gal-1) in the tumor micro-environment (TME) of glioblastoma multiforme (GBM), via nose-to-brain transport. Gal-1 is overexpressed in GBM and drives chemo- and immunotherapy

Externí odkaz: https://doaj.org/article/2a7a658622cc4fa59a489055084f3169

Dabrafenib monotherapy for a recurrent BRAFV600E-mutated TTF-1-positive posterior pituitary tumor

Autor: Flavie Grenier-Chartrand, Sami Barrit, Marie Lucie Racu, Sylvie Luce, Julien Spitaels, Niloufar Sadeghi-Meibodi, Laetitia Lebrun, Isabelle Salmon, Florence Lefranc, Olivier De Witte

Publikováno v: Acta Neurochirurgica. 164:737-742

Posterior pituitary tumors (PPT) expressing thyroid transcription factor-1 (TTF-1) are extremely rare low-grade neoplasms. The recent discovery of BRAF mutations in these tumors offers a potential alternative treatment using targeted therapies. We pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11d695a075146d186949ccad90e9f700
https://doi.org/10.1007/s00701-022-05109-w

Long-term survival with IDH wildtype glioblastoma : first results from the ETERNITY Brain Tumor Funders’ Collaborative Consortium (EORTC 1419)

Autor: Caroline Hertler, Jörg Felsberg, Dorothee Gramatzki, Emilie Le Rhun, Jennifer Clarke, Riccardo Soffietti, Wolfgang Wick, Olivier Chinot, François Ducray, Patrick Roth, Kerrie McDonald, Peter Hau, Andreas F. Hottinger, Jaap Reijneveld, Oliver Schnell, Christine Marosi, Michael Glantz, Amélie Darlix, Giuseppe Lombardi, Dietmar Krex, Martin Glas, David A. Reardon, Martin van den Bent, Florence Lefranc, Ulrich Herrlinger, Evangelia Razis, Antoine F. Carpentier, Samuel Phillips, Roberta Rudà, Antje Wick, Emeline Tabouret, David Meyronet, Claude-Alain Maurage, Elisabeth Rushing, Robert Rapkins, Elisabeth Bumes, Monika Hegi, Astrid Weyerbrock, Dawit Aregawi, Christian Gonzalez-Gomez, Alessia Pellerino, Martin Klein, Matthias Preusser, Martin Bendszus, Vassilis Golfinopoulos, Andreas von Deimling, Thierry Gorlia, Patrick Y. Wen, Guido Reifenberger, Michael Weller

Publikováno v: European Journal of Cancer. Pergamon
Hertler, C, Felsberg, J R, Gramatzki, D, le Rhun, E, Clarke, J, Soffietti, R, Wick, W, Chinot, O, Ducray, F, Roth, P, McDonald, K, Hau, P, Hottinger, A F, Reijneveld, J, Schnell, O, Marosi, C, Glantz, M, Darlix, A, Lombardi, G, Krex, D, Glas, M, Reardon, D A, van den Bent, M, Lefranc, F, Herrlinger, U, Razis, E, Carpentier, A F, Phillips, S, Rudà, R, Wick, A, Tabouret, E, Meyronet, D, Maurage, C-A, Rushing, E, Rapkins, R, Bumes, E, Hegi, M, Weyerbrock, A, Aregawi, D, Gonzalez-Gomez, C, Pellerino, A, Klein, M, Preusser, M, Bendszus, M, Golfinopoulos, V, von Deimling, A, Gorlia, T, Wen, P Y, Reifenberger, G & Weller, M 2023, ' Long-term survival with IDH wildtype glioblastoma : first results from the ETERNITY Brain Tumor Funders’ Collaborative Consortium (EORTC 1419) ', European Journal of Cancer, vol. 189, 112913 . https://doi.org/10.1016/j.ejca.2023.05.002

Background: Median survival with glioblastoma remains in the range of 12 months on population levels. Only few patients survive for more than 5 years. Patient and disease features associated with long-term survival remain poorly defined. Methods: Eur

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::addae152123ca5e3a90614b851863988
https://www.scopus.com/inward/record.url?partnerID=HzOxMe3b&origin=inward&scp=85160695493

Therapy of breast cancer brain metastases: challenges, emerging treatments and perspectives

Autor: Nuria Kotecki, Florence Lefranc, Daniel Devriendt, Ahmad Awada

Publikováno v: Therapeutic Advances in Medical Oncology, Vol 10 (2018)

Brain metastases are the most common central nervous system tumors in adults, and incidence of brain metastases is increasing due to both improved diagnostic techniques (e.g. magnetic resonance imaging) and increased cancer patient survival through a

Externí odkaz: https://doaj.org/article/edc45d920030461ebe7c9a615e9eb131