Zobrazeno 1 - 10
of 210
pro vyhledávání: '"Florea Lupu"'
Autor:
Mihnea P. Dragomir, Enrique Fuentes-Mattei, Melanie Winkle, Keishi Okubo, Recep Bayraktar, Erik Knutsen, Aiham Qdaisat, Meng Chen, Yongfeng Li, Masayoshi Shimizu, Lan Pang, Kevin Liu, Xiuping Liu, Simone Anfossi, Huanyu Zhang, Ines Koch, Anh M. Tran, Swati Mohapatra, Anh Ton, Mecit Kaplan, Matthew W. Anderson, Spencer J. Rothfuss, Robert Silasi, Ravi S. Keshari, Manuela Ferracin, Cristina Ivan, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Constantin Georgescu, Pinaki P. Banerjee, Rafet Basar, Ziyi Li, David Horst, Catalin Vasilescu, Maria Teresa S. Bertilaccio, Katayoun Rezvani, Florea Lupu, Sai-Ching Yeung, George A. Calin
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 14 (2023)
Sepsis remains a leading cause of death for humans and currently has no pathogenesis-specific therapy. Hampered progress is partly due to a lack of insight into deep mechanistic processes. In the past decade, deciphering the functions of small noncod
Externí odkaz:
https://doaj.org/article/d4033ceefb364ffba4d3f09a718cc569
Autor:
Yuji Kondo, Jason L. Larabee, Liang Gao, Huiping Shi, Bojing Shao, Christopher M. Hoover, J. Michael McDaniel, Yen-Chun Ho, Robert Silasi-Mansat, Stephanie A. Archer-Hartmann, Parastoo Azadi, R. Sathish Srinivasan, Alireza R. Rezaie, Alain Borczuk, Jeffrey C. Laurence, Florea Lupu, Jasimuddin Ahamed, Rodger P. McEver, James F. Papin, Zhongxin Yu, Lijun Xia
Publikováno v:
JCI Insight, Vol 6, Iss 14 (2021)
Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), remains a pandemic. Severe disease is associated with dysfunction of multiple organs, but some infected cells do not express ACE2, the canoni
Externí odkaz:
https://doaj.org/article/3801c57ff82e4a0eac422412dabc3d90
Autor:
Vikram Raghunathan, Jevgenia Zilberman‐Rudenko, Sven R. Olson, Florea Lupu, Owen J. T. McCarty, Joseph J. Shatzel
Publikováno v:
Research and Practice in Thrombosis and Haemostasis, Vol 3, Iss 3, Pp 331-339 (2019)
Abstract The contact pathway factors XI (FXI) and XII (FXII) have been demonstrated to be largely dispensable for hemostasis, as their absence results in a mild to absent bleeding diathesis. A growing body of literature, however, suggests that the co
Externí odkaz:
https://doaj.org/article/0cc50be903824b2e926d972c9677fae5
Autor:
Hala Chaaban, Maulin M. Patel, Kathryn Burge, Jeffrey V. Eckert, Cristina Lupu, Ravi S. Keshari, Robert Silasi, Girija Regmi, MaJoi Trammell, David Dyer, Steven J. McElroy, Florea Lupu
Publikováno v:
Microorganisms, Vol 10, Iss 3, p 519 (2022)
Increasing evidence suggests that prolonged antibiotic therapy in preterm infants is associated with increased mortality and morbidities, such as necrotizing enterocolitis (NEC), a devastating gastrointestinal pathology characterized by intestinal in
Externí odkaz:
https://doaj.org/article/3605f9087b644617a63fa315a632cb04
Autor:
Gerben Marsman, Helen von Richthofen, Ingrid Bulder, Florea Lupu, Jan Hazelzet, Brenda M. Luken, Sacha Zeerleder
Publikováno v:
Blood Advances, Vol 1, Iss 26, Pp 2491-2502 (2017)
Abstract: Circulating histones have been implicated as major mediators of inflammatory disease because of their strong cytotoxic effects. Histones form the protein core of nucleosomes; however, it is unclear whether histones and nucleosomes are equal
Externí odkaz:
https://doaj.org/article/9aa3cde212ae48f783b2ded1096ec76e
Autor:
Enrique Fuentes-Mattei, Dana Elena Giza, Masayoshi Shimizu, Cristina Ivan, John T. Manning, Stefan Tudor, Maria Ciccone, Osman Aykan Kargin, Xinna Zhang, Pilar Mur, Nayra Soares do Amaral, Meng Chen, Jeffrey J. Tarrand, Florea Lupu, Alessandra Ferrajoli, Michael J. Keating, Catalin Vasilescu, Sai-Ching Jim Yeung, George A. Calin
Publikováno v:
EBioMedicine, Vol 20, Iss C, Pp 182-192 (2017)
Prevalence of Kaposi sarcoma-associated herpesvirus (KSHV/HHV-8) varies greatly in different populations. We hypothesized that the actual prevalence of KSHV/HHV8 infection in humans is underestimated by the currently available serological tests. We a
Externí odkaz:
https://doaj.org/article/ea20ee8cc5e7490b8007c7c46168ed75
Publikováno v:
Microorganisms, Vol 8, Iss 7, p 1039 (2020)
Neutrophils are the most abundant innate cell population and a key immune player against invading pathogens. Neutrophils can kill both bacterium and spores of Bacillus anthracis, the causative anthrax pathogen. Unlike interactions with professional p
Externí odkaz:
https://doaj.org/article/6a1f078d648c4010a2bb59108c755a14
Autor:
Maulin M. Patel, Amanda R. Behar, Robert Silasi, Girija Regmi, Christopher L. Sansam, Ravi S. Keshari, Florea Lupu, Cristina Lupu
Publikováno v:
Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, Vol 7, Iss 22 (2018)
Background The physiological function of ADTRP (androgen‐dependent tissue factor pathway inhibitor regulating protein) is unknown. We previously identified ADTRP as coregulating with and supporting the anticoagulant activity of tissue factor pathwa
Externí odkaz:
https://doaj.org/article/d9c6d72becd448488f6b53dd5124b376
Autor:
Kenneth W. Jackson, Victoria J. Christiansen, Vivek R. Yadav, Robert Silasi-Mansat, Florea Lupu, Vibhudutta Awasthi, Roy R. Zhang, Patrick A. McKee
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 17, Iss 1, Pp 43-54 (2015)
Tumor microenvironments (TMEs) are composed of cancer cells, fibroblasts, extracellular matrix, microvessels, and endothelial cells. Two prolyl endopeptidases, fibroblast activation protein (FAP) and prolyl oligopeptidase (POP), are commonly overexpr
Externí odkaz:
https://doaj.org/article/1c02253565a2418eb5f3cf7babcec029
Publikováno v:
PLoS Genetics, Vol 9, Iss 12, p e1004031 (2013)
The extracellular matrix (ECM) supports vascular integrity during embryonic development. Proteolytic degradation of ECM components is required for angiogenesis, but excessive ECM proteolysis causes blood vessel fragility and hemorrhage. Little is und
Externí odkaz:
https://doaj.org/article/88dafbae9e9e462cb09a903d3dc22869