Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Flore Kruiswijk"'
Autor:
David Novo, Nikki Heath, Louise Mitchell, Giuseppina Caligiuri, Amanda MacFarlane, Dide Reijmer, Laura Charlton, John Knight, Monika Calka, Ewan McGhee, Emmanuel Dornier, David Sumpton, Susan Mason, Arnaud Echard, Kerstin Klinkert, Judith Secklehner, Flore Kruiswijk, Karen Vousden, Iain R. Macpherson, Karen Blyth, Peter Bailey, Huabing Yin, Leo M. Carlin, Jennifer Morton, Sara Zanivan, Jim C. Norman
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Some p53 mutants promote invasive migration of cancer cells and metastasis of tumours in vivo. However the key mechanistic details behind these phenomena remain unclear. Here the authors propose a non-cell autonomous mechanism involving fibroblasts,
Externí odkaz:
https://doaj.org/article/5887f05591104f9e9068f2413b7885fd
Autor:
Roberto Magliozzi, Zunamys I. Carrero, Teck Yew Low, Laurensia Yuniati, Christian Valdes-Quezada, Flore Kruiswijk, Koen van Wijk, Albert J.R. Heck, Catherine L. Jackson, Daniele Guardavaccaro
Publikováno v:
Cell Reports, Vol 23, Iss 11, Pp 3381-3391.e4 (2018)
Summary: Although much is known about how chromosome segregation is coupled to cell division, how intracellular organelles partition during mitotic division is poorly understood. We report that the phosphorylation-dependent degradation of the ARFGEF
Externí odkaz:
https://doaj.org/article/58b9683cd7e84ae19e87ef3e9931e02d
Autor:
Susan M. Mason, John R. P. Knight, Arnaud Echard, Giuseppina Caligiuri, Dide Reijmer, Monika Calka, Flore Kruiswijk, David Sumpton, David Novo, Karen Blyth, Iain R. Macpherson, Karen H. Vousden, Peter Bailey, Sara Zanivan, Kerstin Klinkert, Jim C. Norman, Judith Secklehner, Amanda MacFarlane, Nikki Heath, Huabing Yin, Jennifer P. Morton, Leo M. Carlin, Louise Mitchell, Ewan J. McGhee, Laura Charlton, Emmanuel Dornier
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-17 (2018)
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Nature Communications, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Novo, D, Heath, N, Mitchell, L, Caligiuri, G, MacFarlane, A, Reijmer, D, Charlton, L, Knight, J, Calka, M, McGhee, E, Dornier, E, Sumpton, D, Mason, S, Echard, A, Klinkert, K, Secklehner, J, Kruiswijk, F, Vousden, K, Macpherson, I R, Blyth, K, Bailey, P, Yin, H, Carlin, L M, Morton, J, Zanivan, S & Norman, J C 2018, ' Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels ', Nature Communications, vol. 9, no. 1, 5069 . https://doi.org/10.1038/s41467-018-07339-y
Nature Communications
Nature Communications, Nature Publishing Group, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Nature Communications, 2018, 9 (1), pp.5069. ⟨10.1038/s41467-018-07339-y⟩
Novo, D, Heath, N, Mitchell, L, Caligiuri, G, MacFarlane, A, Reijmer, D, Charlton, L, Knight, J, Calka, M, McGhee, E, Dornier, E, Sumpton, D, Mason, S, Echard, A, Klinkert, K, Secklehner, J, Kruiswijk, F, Vousden, K, Macpherson, I R, Blyth, K, Bailey, P, Yin, H, Carlin, L M, Morton, J, Zanivan, S & Norman, J C 2018, ' Mutant p53s generate pro-invasive niches by influencing exosome podocalyxin levels ', Nature Communications, vol. 9, no. 1, 5069 . https://doi.org/10.1038/s41467-018-07339-y
Mutant p53s (mutp53) increase cancer invasiveness by upregulating Rab-coupling protein (RCP) and diacylglycerol kinase-α (DGKα)-dependent endosomal recycling. Here we report that mutp53-expressing tumour cells produce exosomes that mediate intercel
Autor:
Oliver D. K. Maddocks, Dimitris Athineos, Eric C. Cheung, Pearl Lee, Tong Zhang, Niels J. F. van den Broek, Gillian M. Mackay, Christiaan F. Labuschagne, David Gay, Flore Kruiswijk, Julianna Blagih, David F. Vincent, Kirsteen J. Campbell, Fatih Ceteci, Owen J. Sansom, Karen Blyth, Karen H. Vousden
Publikováno v:
Nature. 544:372-376
The non-essential amino acids serine and glycine are used in multiple anabolic processes that support cancer cell growth and proliferation (reviewed in ref. 1). While some cancer cells upregulate de novo serine synthesis, many others rely on exogenou
Autor:
Julianna Blagih, Mylène Tajan, Andreas K. Hock, Christiaan F. Labuschagne, Peter D. Adams, Flore Kruiswijk, Neil Robertson, Karen H. Vousden
Publikováno v:
ESMO Open. 3:A19-A20
Introduction Cancer cells are frequently exposed to nutrient and oxygen limited environments, resulting from poor vascularisation in the developing tumour mass, and there is a growing interest in understanding the metabolic plasticity that supports c
Autor:
Shabaz Mohammed, Albert J. R. Heck, Christopher G. Proud, Flore Kruiswijk, Laurensia Yuniati, Renske Bolder, Daniele Guardavaccaro, Ratna Lim, Michele Pagano, Teck Yew Low, Roberto Magliozzi
Publikováno v:
Science Signaling, 5(227). American Association for the Advancement of Science (AAAS)
Science Signaling, 5, ra40-ra40
Science Signaling, 5, 227, pp. ra40-ra40
Science Signaling, 5, ra40-ra40
Science Signaling, 5, 227, pp. ra40-ra40
Item does not contain fulltext The kinase eEF2K [eukaryotic elongation factor 2 (eEF2) kinase] controls the rate of peptide chain elongation by phosphorylating eEF2, the protein that mediates the movement of the ribosome along the mRNA by promoting t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2dcaacbedb371d77f0ac3e8908a2f9c
https://doi.org/10.1126/scisignal.2002718
https://doi.org/10.1126/scisignal.2002718
Autor:
N J F van den Broek, Judith Campisi, D Putavet, D C van Gent, Boudewijn M.T. Burgering, P L J de Keizer, J.H.J. Hoeijmakers, M P Baar, Arjan B. Brenkman, K.A.T. Naipal, Flore Kruiswijk, Renuka Sivapatham, P.J. van der Spek, Wim H. J. Kruit, Sebastian C. Hasenfuss
Publikováno v:
Oncogene, 35(17), 2166-2177. Nature Publishing Group
Oncogene
Oncogene, 35(17), 2166. Nature Publishing Group
Oncogene
Oncogene, 35(17), 2166. Nature Publishing Group
Melanoma is the most lethal form of skin cancer and successful treatment of metastatic melanoma remains challenging. BRAF/MEK inhibitors only show a temporary benefit due to rapid occurrence of resistance, whereas immunotherapy is mainly effective in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2d159499dd1b43e3fd7972e28f4a7040
https://pure.eur.nl/en/publications/65ad3aa2-05f7-42e8-9673-cab4e71557c6
https://pure.eur.nl/en/publications/65ad3aa2-05f7-42e8-9673-cab4e71557c6
Autor:
Christiaan F. Labuschagne, Flore Kruiswijk, Julianna Blagih, Timothy J. Humpton, Neil Robertson, Karen H. Vousden, Mylène Tajan, Peter D. Adams, Andreas K. Hock
Publikováno v:
Cell Metabolism
Summary Numerous mechanisms to support cells under conditions of transient nutrient starvation have been described. Several functions of the tumor-suppressor protein p53 can contribute to the adaptation of cells to metabolic stress and help cancer ce
Publikováno v:
Nature reviews. Molecular cell biology. 16(7)
The function of p53 as a tumour suppressor has been attributed to its ability to promote cell death or permanently inhibit cell proliferation. However, in recent years, it has become clear that p53 can also contribute to cell survival. p53 regulates
Autor:
Oliver D. K. Maddocks, Dimitris Athineos, Eric C. Cheung, Pearl Lee, Tong Zhang, Niels J. F. van den Broek, Gillian M. Mackay, Christiaan F. Labuschagne, David Gay, Flore Kruiswijk, Julianna Blagih, David F. Vincent, Kirsteen J. Campbell, Fatih Ceteci, Owen J. Sansom, Karen Blyth, Karen H. Vousden
Publikováno v:
Nature. 548:122-122
Nature 544, 372–376 (2017); doi:10.1038/nature22056 In this Letter, the ‘Diet 1’ formulation was incorrectly referenced as our previously published diet (ref. 7 of the Letter). The correct amino acid composition of the diets was stated in the M