Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Flore De Wit"'
Publikováno v:
mBio, Vol 13, Iss 4 (2022)
ABSTRACT Current antiretroviral treatment fails to cure HIV-1 infection since latent provirus resides in long-lived cellular reservoirs, rebounding whenever therapy is discontinued. The molecular mechanisms underlying HIV-1 latency are complex where
Externí odkaz:
https://doaj.org/article/a7504e6465124977b558a457b27dfe9a
Autor:
Julie Janssens, Jolien Blokken, Yulia Lampi, Flore De Wit, Irena Zurnic Bonisch, Ivan Nombela, Paulien Van de Velde, Barbara Van Remoortel, Rik Gijsbers, Frauke Christ, Zeger Debyser
Publikováno v:
Microbiology Spectrum, Vol 9, Iss 2 (2021)
ABSTRACT To infect nondividing cells, HIV-1 needs to cross the nuclear membrane. The importin transportin-SR2 (TRN-SR2 or transportin-3) has been proposed to mediate HIV-1 nuclear import, but the detailed mechanism remains unresolved. The direct inte
Externí odkaz:
https://doaj.org/article/eae56d4cb1844f6b9da345e70479dfd4
Autor:
Caroline Weydert, Bart van Heertum, Lieve Dirix, Stéphanie De Houwer, Flore De Wit, Jan Mast, Steven J Husson, Katrien Busschots, Renate König, Rik Gijsbers, Jan De Rijck, Zeger Debyser
Publikováno v:
PLoS ONE, Vol 15, Iss 10, p e0241893 (2020)
[This corrects the article DOI: 10.1371/journal.pone.0200080.].
Externí odkaz:
https://doaj.org/article/8e5839d79b054475977f6128aa603a7b
Autor:
Sara Rodríguez-Mora, Flore De Wit, Javier García-Perez, Mercedes Bermejo, María Rosa López-Huertas, Elena Mateos, Pilar Martí, Susana Rocha, Lorena Vigón, Frauke Christ, Zeger Debyser, Juan Jesús Vílchez, Mayte Coiras, José Alcamí
Publikováno v:
PLoS Pathogens, Vol 15, Iss 8, p e1007958 (2019)
The causative mutation responsible for limb girdle muscular dystrophy 1F (LGMD1F) is one heterozygous single nucleotide deletion in the stop codon of the nuclear import factor Transportin 3 gene (TNPO3). This mutation causes a carboxy-terminal extens
Externí odkaz:
https://doaj.org/article/4e773c58f83a4eb5b4da09a63b2f9f9d
Autor:
Caroline Weydert, Bart van Heertum, Lieve Dirix, Stéphanie De Houwer, Flore De Wit, Jan Mast, Steven J Husson, Katrien Busschots, Renate König, Rik Gijsbers, Jan De Rijck, Zeger Debyser
Publikováno v:
PLoS ONE, Vol 13, Iss 7, p e0200080 (2018)
The human immunodeficiency virus (HIV) depends on cellular proteins, so-called cofactors, to complete its replication cycle. In search for new therapeutic targets we identified the DNA and RNA binding protein Y-box-binding Protein 1 (YB-1) as a cofac
Externí odkaz:
https://doaj.org/article/568305c92cf64c628a7ff633c1154e2c
Autor:
Akkaladevi Venkatesham, Sambasiva Rao Pillalamarri, Flore De Wit, Eveline Lescrinier, Zeger Debyser, Arthur Van Aerschot
Publikováno v:
Molecules, Vol 24, Iss 3, p 468 (2019)
In vivo imaging of biological processes is an important asset of modern cell biology. Selectively reacting fluorophores herein are an important tool and click chemistry reactions take a large share in these events. 5-Ethynyl-2′-deoxyuridine (EdU) i
Externí odkaz:
https://doaj.org/article/01eaf417dd954d55a654ea4902bf3754
Autor:
Ivan Nombela, Yulia Lampi, Irena Zurnic Bonisch, Rik Gijsbers, Julie Janssens, Zeger Debyser, Paulien Van de Velde, Jolien Blokken, Flore De Wit, Frauke Christ, Barbara Van Remoortel
Publikováno v:
Microbiology Spectrum
Microbiology Spectrum, Vol 9, Iss 2 (2021)
Microbiology Spectrum, Vol 9, Iss 2 (2021)
To infect nondividing cells, HIV-1 needs to cross the nuclear membrane. The importin transportin-SR2 (TRN-SR2 or transportin-3) has been proposed to mediate HIV-1 nuclear import, but the detailed mechanism remains unresolved. The direct interaction o
Autor:
Frank Vernaillen, Jelle Hendrix, Frauke Christ, Irena Zurnic Bonisch, Lieve Dirix, Flore De Wit, Doortje Borrenberghs, Susana Rocha, Veerle Lemmens, Johan Hofkens, Zeger Debyser
Publikováno v:
J Virol
The HIV-1 capsid protein performs multiple roles in virus replication both during assembly and particle release and during virus trafficking into the nucleus. In order to decipher the roles of capsid protein during early replication, a reliable metho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4349d714ace64683702a209c8d73c9ba
https://lirias.kuleuven.be/handle/123456789/649481
https://lirias.kuleuven.be/handle/123456789/649481
Autor:
Frauke Christ, Zeger Debyser, Jolien Breemans, Sergei V. Strelkov, Vicky G. Tsirkone, Jolien Blokken, Flore De Wit, Stéphanie De Houwer
Publikováno v:
Journal of Biological Chemistry. 292:9699-9710
The karyopherin transportin SR2 (TRN-SR2, TNPO3) is responsible for shuttling specific cargoes such as serine/arginine-rich splicing factors from the cytoplasm to the nucleus. This protein plays a key role in HIV infection by facilitating the nuclear
Autor:
Alba Sebastián-Martín, Arthur Van Aerschot, Flore De Wit, Sambasiva Rao Pillalamarri, Zeger Debyser, Akkaladevi Venkatesham
Publikováno v:
J Biol Chem
Only a small portion of human immunodeficiency virus type 1 (HIV-1) particles entering the host cell results in productive infection, emphasizing the importance of identifying the functional virus population. Because integration of viral DNA (vDNA) i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d393a3c9b2992570c01d98241078aba7
https://lirias.kuleuven.be/handle/123456789/639964
https://lirias.kuleuven.be/handle/123456789/639964