Zobrazeno 1 - 10
of 2 341
pro vyhledávání: '"Flora S"'
Autor:
Michelle H F Dias, Luiz F F Guimarães, Matheus G Barcelos, Eduardo U M Moreira, Maria F A do Nascimento, Taís N de Souza, Camilla V Pires, Talita A F Monteiro, Jaap M Middeldorp, Irene S Soares, Cor J F Fontes, Francis B Ntumngia, John H Adams, Flora S Kano, Luzia H Carvalho
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 8, p e0010305 (2022)
BackgroundThe simultaneous infection of Plasmodium falciparum and Epstein-Barr virus (EBV) could promote the development of the aggressive endemic Burkitt's Lymphoma (eBL) in children living in P. falciparum holoendemic areas. While it is well-establ
Externí odkaz:
https://doaj.org/article/4d76b74a2aee4d979bdd97a87055a764
Autor:
Bárbara A S Lima, Gabriela M Fernandes, Letícia M Torres, Camilla V Pires, Jéssica R S Alves, Sâmick L Moreira-Nascimento, Maria Fernanda A Nascimento, Sofia L Afonso, Helena L Costa, Isabela P Cerávolo, Tais N Sousa, Irene S Soares, Francis B Ntumngia, John H Adams, Luzia H Carvalho, Flora S Kano
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 16, Iss 6, p e0010493 (2022)
Plasmodium vivax blood-stage invasion into reticulocyte is critical for parasite development. Thus, validation of novel parasite invasion ligands is essential for malaria vaccine development. Recently, we demonstrated that EBP2, a Duffy binding prote
Externí odkaz:
https://doaj.org/article/093e8018a76640ec9b67fa9b7e179577
Autor:
Jéssica R. S. Alves, Fernanda F. de Araújo, Camilla V. Pires, Andréa Teixeira-Carvalho, Barbara A. S. Lima, Letícia M. Torres, Francis B. Ntumngia, John H. Adams, Flora S. Kano, Luzia H. Carvalho
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Malaria remains a major public health problem worldwide, and Plasmodium vivax is the most widely distributed malaria parasite. Naturally acquired binding inhibitory antibodies (BIAbs) to region II of the Duffy binding protein (DBPII), a P. vivax liga
Externí odkaz:
https://doaj.org/article/628e62a8339048bfbb3308f79c6b28e1
Autor:
Camila M P Medeiros, Eduardo U M Moreira, Camilla V Pires, Letícia M Torres, Luiz F F Guimarães, Jéssica R S Alves, Bárbara A S Lima, Cor J F Fontes, Helena L Costa, Cristiana F A Brito, Tais N Sousa, Francis B Ntumngia, John H Adams, Flora S Kano, Luzia H Carvalho
Publikováno v:
PLoS ONE, Vol 15, Iss 5, p e0232786 (2020)
BackgroundA low proportion of P. vivax-exposed individuals acquire protective strain-transcending neutralizing IgG antibodies that are able to block the interaction between the Duffy binding protein II (DBPII) and its erythrocyte-specific invasion re
Externí odkaz:
https://doaj.org/article/3aca50777f6b4975b83cd4ca33d5007a
Autor:
Carl A. Machutta, Christopher S. Kollmann, Kenneth E. Lind, Xiaopeng Bai, Pan F. Chan, Jianzhong Huang, Lluis Ballell, Svetlana Belyanskaya, Gurdyal S. Besra, David Barros-Aguirre, Robert H. Bates, Paolo A. Centrella, Sandy S. Chang, Jing Chai, Anthony E. Choudhry, Aaron Coffin, Christopher P. Davie, Hongfeng Deng, Jianghe Deng, Yun Ding, Jason W. Dodson, David T. Fosbenner, Enoch N. Gao, Taylor L. Graham, Todd L. Graybill, Karen Ingraham, Walter P. Johnson, Bryan W. King, Christopher R. Kwiatkowski, Joël Lelièvre, Yue Li, Xiaorong Liu, Quinn Lu, Ruth Lehr, Alfonso Mendoza-Losana, John Martin, Lynn McCloskey, Patti McCormick, Heather P. O’Keefe, Thomas O’Keeffe, Christina Pao, Christopher B. Phelps, Hongwei Qi, Keith Rafferty, Genaro S. Scavello, Matt S. Steiginga, Flora S. Sundersingh, Sharon M. Sweitzer, Lawrence M. Szewczuk, Amy Taylor, May Fern Toh, Juan Wang, Minghui Wang, Devan J. Wilkins, Bing Xia, Gang Yao, Jean Zhang, Jingye Zhou, Christine P. Donahue, Jeffrey A. Messer, David Holmes, Christopher C. Arico-Muendel, Andrew J. Pope, Jeffrey W. Gross, Ghotas Evindar
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-11 (2017)
Encoded Library Technology (ELT) has streamlined the identification of chemical ligands for protein targets in drug discovery. Here, the authors optimize the ELT approach to screen multiple proteins in parallel and identify promising targets and anti
Externí odkaz:
https://doaj.org/article/a0c4424f2eeb46a689586e4828ae7887
Autor:
Catherine J. Mitran, Angie Mena, Sedami Gnidehou, Shanna Banman, Eliana Arango, Barbara A. S. Lima, Hazel Lugo, Aravindhan Ganesan, Ali Salanti, Anthony K. Mbonye, Francis Ntumngia, Khaled Barakat, John H. Adams, Flora S. Kano, Luzia H. Carvalho, Amanda E. Maestre, Michael F. Good, Stephanie K. Yanow
Publikováno v:
mBio, Vol 10, Iss 5 (2019)
ABSTRACT Many pathogens evolve extensive genetic variation in virulence proteins as a strategy to evade host immunity. This poses a significant challenge for the host to develop broadly neutralizing antibodies. In Plasmodium falciparum, we show that
Externí odkaz:
https://doaj.org/article/dc9b125d83b4466294dd90ec1b790353
Publikováno v:
Frontiers in Psychiatry, Vol 9 (2018)
Ketamine is a popular recreational drug among young people in Hong Kong. Long-term abuse of ketamine can lead to acute urological and medical issues, which often require immediate care at emergency rooms. Many patients require short-term hospitalizat
Externí odkaz:
https://doaj.org/article/e86bc86918d84416868100a295ca6a88
Autor:
Camilla V Pires, Jessica R S Alves, Barbara A S Lima, Ruth B Paula, Helena L Costa, Leticia M Torres, Taís N Sousa, Irene S Soares, Bruno A M Sanchez, Cor J F Fontes, Francis B Ntumngia, John H Adams, Flora S Kano, Luzia H Carvalho
Publikováno v:
PLoS ONE, Vol 13, Iss 11, p e0207244 (2018)
Plasmodium vivax remains a global health problem and its ability to cause relapses and subpatent infections challenge control and elimination strategies. Even in low malaria transmission settings, such as the Amazon basin, where progress in malaria c
Externí odkaz:
https://doaj.org/article/d6f95929b1f64ae3bcf0124c61348167
Autor:
Flora S Kano, Flávia A Souza-Silva, Leticia M Torres, Barbara A S Lima, Taís N Sousa, Jéssica R S Alves, Roberto S Rocha, Cor J F Fontes, Bruno A M Sanchez, John H Adams, Cristiana F A Brito, Douglas E V Pires, David B Ascher, Ana Maria Sell, Luzia H Carvalho
Publikováno v:
PLoS Neglected Tropical Diseases, Vol 10, Iss 12, p e0005177 (2016)
BACKGROUND:The human malaria parasite Plasmodium vivax infects red blood cells through a key pathway that requires interaction between Duffy binding protein II (DBPII) and its receptor on reticulocytes, the Duffy antigen/receptor for chemokines (DARC
Externí odkaz:
https://doaj.org/article/e7e828c92990415fbd2b17622746241b
Autor:
Gustavo C Cassiano, Adriana A C Furini, Marcela P Capobianco, Luciane M Storti-Melo, Maristela G Cunha, Flora S Kano, Luzia H Carvalho, Irene S Soares, Sidney E Santos, Marinete M Póvoa, Ricardo L D Machado
Publikováno v:
PLoS ONE, Vol 11, Iss 2, p e0149581 (2016)
The development of an effective immune response can help decrease mortality from malaria and its clinical symptoms. However, this mechanism is complex and has significant inter-individual variation, most likely owing to the genetic contribution of th
Externí odkaz:
https://doaj.org/article/23400a674f614cae9130d8167c937415