Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Flora Jow"'
Autor:
Flora Jow, Istvan J. Enyedy, Darren P. Baker, Catherine Hession, Chris Bergeron, Kenneth J. Rhodes, Robert H. Scannevin, Cassandra F. Borenstein, Gnanasambandam Kumaravel, Edward Yin-Shiang Lin, Timothy R. Chan, Anthone W. Dunah, Richard L. Huganir, Laura Silvian, Jinming Zou, Robert M. Arduini, Fang Qian, Ellen Rohde, Kevin Guckian, Marion Wittmann, Douglas Marcotte, Charles C. Banos
Publikováno v:
Scientific Reports
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Protein interacting with C kinase (PICK1) is a scaffolding protein that is present in dendritic spines and interacts with a wide array of proteins through its PDZ domain. The best understood function of PICK1 is regulation of trafficking of AMPA rece
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::809e124eb19a18665035c8a00f6cabaf
http://europepmc.org/articles/PMC6128908
http://europepmc.org/articles/PMC6128908
Autor:
Thomas A. Comery, John Dunlop, Laura Maccari, Eva Genesio, Flora Jow, Carmela Pratelli, Chiara Ghiron, Riccardo Zanaletti, Elisa Turlizzi, Ilaria Ceccarelli, Laura Bettinetti, Iolanda Micco, Carla Scali, Simon N. Haydar, Arianna Nencini, Michela Valacchi, Cristiana Castaldo, Giuseppe Cocconcelli
Publikováno v:
Journal of Medicinal Chemistry. 55:10277-10281
α7 Nicotinic acetylcholine receptors (α7 nAChR) represent promising therapeutic candidates for the treatment of cognitive impairment associated with Alzheimer's disease (AD) and schizophrenia. A medicinal chemistry effort around previously reported
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::98800eb6cf37051f3ec70e6b3f324b99
https://doi.org/10.1021/jm3013568
https://doi.org/10.1021/jm3013568
Autor:
Riccardo Zanaletti, John Dunlop, Flora Jow, Laura Maccari, Michela Valacchi, Iolanda Micco, Elisa Turlizzi, Cristiana Castaldo, Giovanni Gaviraghi, Simon N. Haydar, Giuseppe Cocconcelli, Thomas A. Comery, Chiara Ghiron, Laura Bettinetti, Carla Scali, Arianna Nencini
Publikováno v:
Journal of Medicinal Chemistry. 55:4806-4823
Alpha-7 nicotinic acetylcholine receptors (α7 nAChR) are implicated in the modulation of many cognitive functions such as attention, working memory, and episodic memory. For this reason, α7 nAChR agonists represent promising therapeutic candidates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4d0dae84961ada3602bc2ed9d734b4f
https://doi.org/10.1021/jm300247y
https://doi.org/10.1021/jm300247y
Autor:
Fabrizio Sitzia, Renza Roncarati, Thomas A. Comery, Brian Jow, Mark R. Bowlby, Dianne Kowal, Flora Jow, Adam M. Gilbert, Veronica Soloveva, Larocque James Paul, Tim Lock, Angela Kramer, John Dunlop, Andrew D. Randall, Steven M. Grauer, Jon T. Brown
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 328:766-776
The α7 nicotinic acetylcholine receptor (nAChR) has been implicated in Alzheimer's disease and schizophrenia, leading to efforts targeted toward discovering agonists and positive allosteric modulators (PAMs) of this receptor. In a Ca2+ flux fluorome
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1fe2685986f3ba41e3b8e35698c9d34e
https://doi.org/10.1124/jpet.108.146514
https://doi.org/10.1124/jpet.108.146514
Autor:
Renza Roncarati, Silvia Papini, John Dunlop, Georg C. Terstappen, Brian Jow, Tamara Seredenina, Hendrick Bothmann, Angela Kramer, Flora Jow
Publikováno v:
ASSAY and Drug Development Technologies. 6:181-193
Heterologous functional expression of alpha7 nicotinic acetylcholine receptors (nAChRs) is difficult to achieve in mammalian cell lines, and the reasons have been associated with a lack of expression of the putative chaperone factor RIC-3. Here, we d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8bc951e024b080c0431884d00c461f7a
https://doi.org/10.1089/adt.2007.120
https://doi.org/10.1089/adt.2007.120
Autor:
Andrew R. Wood, Guy T. Carter, Edmund I. Graziani, Menelas N. Pangalos, Kevin Pong, Frank E. Koehn, Benfang Ruan, Ronald L. Magolda, Magid Abou-Gharbia, Robert A. Crozier, Flora Jow, Frann Bennett, Danni Liu, Mark R. Bowlby, Peter H. Reinhart, Xidong Feng, Mary Lynn T. Mercado, Leonard A. McDonald, Shi Liang, Yi Chen, Jerauld S. Skotnicki, Margaret M. Zaleska, David von Schack
Publikováno v:
Proceedings of the National Academy of Sciences. 105:33-38
Rapamycin is an immunosuppressive immunophilin ligand reported as having neurotrophic activity. We show that modification of rapamycin at the mammalian target of rapamycin (mTOR) binding region yields immunophilin ligands, WYE-592 and ILS-920, with p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c60bb03f86803494ea3efa91d69a376
https://doi.org/10.1073/pnas.0710424105
https://doi.org/10.1073/pnas.0710424105
Publikováno v:
ASSAY and Drug Development Technologies. 4:49-56
F11 cells are derived from a fusion between mouse embryonic neuroblastoma and rat dorsal root ganglion (DRG) neurons. These cells have been shown to retain many features of native DRG neurons, including synthesis of neurotransmitters, expression of n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3424f9118a318da4c29fe26a35c0b6cd
https://doi.org/10.1089/adt.2006.4.49
https://doi.org/10.1089/adt.2006.4.49
Autor:
Diana Chen, Flora Jow, Beal McIlvain, Eugene Tseng, KeWei Wang, Howard Zhang, Qin Jennifer Shan, Qiang Lu, Dianne Kowal, Ru Shen, Lan He, John Dunlop
Publikováno v:
ASSAY and Drug Development Technologies. 2:525-534
M-channels (M-current), encoded by KCNQ2/3 K(+) channel genes, have emerged as novel drug targets for a number of neurological disorders. The lack of direct high throughput assays combined with the low throughput of conventional electrophysiology (EP
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64da878443a95137a291fab9c5b4ad69
https://doi.org/10.1089/adt.2004.2.525
https://doi.org/10.1089/adt.2004.2.525
Autor:
Laura Lin, Mark Stahl, William S. Somers, Karen C. Carroll, Zhang-Bao Xu, Pranab K. Chanda, KeWei Wang, Karl Malakian, Robert Scannevin, Flora Jow, Meggin Taylor, Lydia Mosyak, Wade Edris, Alan H. Katz, Jennifer Megules, Stephane Olland, Kenneth J. Rhodes, Mark R. Bowlby, Weixin Xu, Qiang Lu, David C. Kopsco
Publikováno v:
Neuron. 41:587-598
The family of calcium binding proteins called KChIPs associates with Kv4 family K + channels and modulates their biophysical properties. Here, using mutagenesis and X-ray crystallography, we explore the interaction between Kv4 subunits and KChIP1. Tw
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f50525e0eddc63de4b13bdb0e126666c
https://doi.org/10.1016/s0896-6273(04)00049-2
https://doi.org/10.1016/s0896-6273(04)00049-2
Autor:
Randy Numann, Flora Jow
Publikováno v:
The Journal of Physiology. 512:119-128
1. Cultured human capillary endothelial cells (HCEC) contain a large inward rectifier current, IK(IR), that can be abolished by removing external K+ or by adding 50 microM Ba2+. 2. We show that IK(IR) is responsible for maintaining the hyperpolarized
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b450d0fec2b7b8ea1e4f2c9a2c7eb6c
https://doi.org/10.1111/j.1469-7793.1998.119bf.x
https://doi.org/10.1111/j.1469-7793.1998.119bf.x